Results 81 to 90 of about 28,010 (204)
The Complement System in Post‐Transplant Kidney Injury
Organ Medicine, EarlyView.
Mengsi Hu
wiley +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
The Role of the Podocyte in Preeclampsia [PDF]
Clinical Journal of the American Society of Nephrology, 2014 Preeclampsia is a pregnancy-specific hypertensive disorder that affects approximately 5% of pregnancies and remains one of the leading causes of both maternal and fetal morbidity and mortality worldwide ([1][1]).
openaire +2 more sources
Nature CommunicationsThe kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong +9 more
doaj +1 more source
Columbianetin protects from high-glycemic podocyte damage by regulating autophagy
Linchuang shenzangbing zazhi, 2021 Objective To explore the protective effect of columbianetin（CBT）on the injury of podocytes induced by high glucose and its mechanism.Methods Immortalized murine foot cell line MPC-5 was cultured in vitro and the effects of CBT on injury and autophagy ...
Shi Lang, Song Zhi-xia, Zhang Ya-fei
doaj
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Dach1 is essential for maintaining normal mature podocytes.
PLoS ONEDach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice.
Keiko Tanaka +2 more
doaj +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source