Results 101 to 110 of about 28,010 (204)

Targeting YAP1‐Mediated Tubular Cell Senescence to Attenuate Maladaptive Repair and Fibrotic Transition After Acute Kidney Injury

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
YAP1 mediates tubular cell senescence and drives maladaptive repair following AKI, promoting the AKI to CKD transition. Single‐cell RNA‐seq reveals sustained YAP1 overexpression, fibroblast activation, and pro‐fibrotic tubular cell shift. Senolytic agents or verteporfin (YAP1/TEAD1 inhibitor) suppress YAP1 activity, reduce renal senescence, alleviate ...
Zhibo Zhao, Huiping An, Yonghou Sang, Si Chen, Jinxiu Zhou, Tingting Zhang, Junhu Li, Xiaoshuang Zhou   +7 more
wiley   +1 more source

Hodgkin's Lymphoma Presenting With Nephrotic Syndrome and Complicated by Posterior Reversible Encephalopathy Syndrome in a Child: A Rare Multisystem Interaction

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Early recognition of nephrotic syndrome and neurological complications in pediatric Hodgkin's lymphoma is essential. This case highlights a rare association between Hodgkin's lymphoma, nephrotic syndrome, and posterior reversible encephalopathy syndrome, emphasizing the importance of multidisciplinary management and prompt blood pressure ...
Balqees Al‐Shohef, Majd Hamed Nasser, Hind Alhiraki, Sameer Baqla, Othman Hamdan, Mona Hussein   +5 more
wiley   +1 more source

Oxidative Stress‐Induced Expression Levels of PXDN and NF‐κB in Type 2 Diabetic Patients With Nephropathy

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
PXDN expression is markedly upregulated in diabetic nephropathy and, versus NF‐κB and oxidative stress markers, shows superior diagnostic performance (AUC 0.79; 90% specificity), supporting PXDN as a sensitive, specific non‐invasive biomarker for early DN.
Zakira Hanin, Aisha Anees Ahmed, Shuhd Salem Al Nahdi, Sumayya Althaf Kasim, Mahir Khalil Jallo, Rajaram Rhambau Jagdale, Dalia A. Gaber   +6 more
wiley   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology

Kidney International Reports
Introduction: Fabry disease (FD) results from pathogenic GLA variants, leading to a deficiency in lysosomal α-galactosidase A (α-Gal A) and accumulation of the sphingolipid globotriaosylceramide (Gb3).
Andrea F. Wise, IGAA Ari Krisnadevi, Shoni Bruell, Han-Chung Lee, Tejasvini Bhuvan, Andrew J. Kassianos, Sheetal Saini, Xiangju Wang, Helen G. Healy, Elizabeth Ling Qian, David A. Elliot, Joel R Steele, Maria Fuller, Kathleen M. Nicholls, Sharon D. Ricardo   +14 more
doaj   +1 more source

Association of Triglyceride‐Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension

The Journal of Clinical Hypertension, Volume 28, Issue 7, July 2026.
ABSTRACT We aimed to examine the association between insulin resistance (IR) and target organ damage (TOD) in patients with hypertension. Three indices of IR (Triglyceride‐Glucose index: TyG; triglyceride‐to‐HDL ratio: TG/HDL‐C; Metabolic Score for Insulin Resistance: METS‐IR) were examined for their association with TOD in 614 newly diagnosed patients
Ionas Papasotiriou, Anastasios Tentolouris, Sotiria Spiliopoulou, Theodoros N. Sergentanis, Efstathios Manios   +4 more
wiley   +1 more source

Compartment‐Specific Immune Remodeling of Renal Aging With C1q‐Associated Podocyte Activation

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Aging repatterns the renal immune response in a compartment‐specific manner, distinct from chronic kidney disease (CKD) adaptation. Glomerular aging features C1q‐associated podocyte activation and macrophage engagement, whereas tubulointerstitial aging is marked by B‐cell aggregation and tertiary lymphoid structure expansion.
Ju‐Young Moon, Kyuwon Shim, Hyun Ji Lim, Dae‐Kyu Kim, Young Yoon Moon, Su‐Woong Jung, Yang‐Gyun Kim, Hyuno Kang, Tae‐Hoon Lee, Jae‐Hyung Lee, Sang‐Ho Lee   +10 more
wiley   +1 more source

[Podocyte dysfunction and proteinuria].

Nederlands tijdschrift voor geneeskunde, 2004
Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J., Rietjens, S.J., Vlag, J. van der, Berden, J.H.M.   +3 more
openaire   +3 more sources

A human stem cell-derived model reveals pathologic extracellular matrix remodeling in diabetic podocyte injury

Matrix Biology Plus
Diabetic nephropathy results from chronic (or uncontrolled) hyperglycemia and is the leading cause of kidney failure. The kidney’s glomerular podocytes are highly susceptible to diabetic injury and subsequent non-reversible degeneration.
Yasmin Roye, Carmen Miller, Titilola D. Kalejaiye, Samira Musah   +3 more
doaj   +1 more source

Effect of Irbesartan on TRPC6 expression in high glucose-induced mouse podocytes

Linchuang shenzangbing zazhi, 2016
Objective To study the effect of irbesartan（angiotensin Ⅱ receptor blocker） on the expression of TRPC6 in high glucose-induced conditional immortalized mouse podocytes.Methods The conditional immortalized mouse podocytes were cultured in vitro and ...
HU Chun-li, XIE Xi-sheng, FENG Sheng-gang   +2 more
doaj