Results 121 to 130 of about 27,473 (231)

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Effect of Irbesartan on TRPC6 expression in high glucose-induced mouse podocytes

Linchuang shenzangbing zazhi, 2016
Objective To study the effect of irbesartan（angiotensin Ⅱ receptor blocker） on the expression of TRPC6 in high glucose-induced conditional immortalized mouse podocytes.Methods The conditional immortalized mouse podocytes were cultured in vitro and ...
HU Chun-li, XIE Xi-sheng, FENG Sheng-gang   +2 more
doaj  

Characterization of NLRP3 Inflammasome‐Associated Hub Genes in the Progression of Diabetic Nephropathy

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao, Yuejiao Li, Wenchuan Li, Lan Dong, Rong Lian, Qingqing Luo, Xingji Lian, Jianbo Li, Feng He   +8 more
wiley   +1 more source

Immune podocyte injury in autoimmune glomerular diseases. [PDF]

Front Immunol
Zhu H, Sun J, Yan Y, Liu P, Huang Y.
europepmc   +1 more source

Magnetic‐Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Mag‐SELEX identified the first aptamer targeting migrasome, offering a potential ligand for their identification and detection in clinical samples. The magnetic aptamer probe, characterised by high specificity and rapid recovery, provides a simple, rapid, and economical method for elucidating migrasome mechanisms in disease and facilitating ...
Yixin Xu, Lin Jiao, Qiangying Yi, Yuzuo Chen, Bei Cai, Junlong Zhang, Zhuochun Huang, Yao Luo, Yanjun Si, Yao Wu, Binwu Ying, Jie Chen, Juan Zhou   +12 more
wiley   +1 more source

Podometrics as a translational platform for kidney health and disease: Oshima award address 2025. [PDF]

Clin Exp Nephrol
Haruhara K.
europepmc   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress. [PDF]

Acta Physiol (Oxf)
Melica ME, Antonelli G, Peired AJ, Lasagni L.   +3 more
europepmc   +1 more source

The IQGAP1‐Claudin4‐JNK Signaling Axis as a Differential Biomarker in Renal Cell Carcinoma

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Renal cell carcinoma (RCC) is a highly heterogeneous malignant neoplasm with multiple morphological and molecular subtypes; however, the basis of this heterogeneity remains incompletely defined, hindering effective diagnosis and treatment. The signaling scaffold IQGAP1 and claudins are tight junction protein partners involved in epithelial ...
Nahshon Puente, Xiuzhen Fan, Nagalakshmi Nadiminty, Obi Ekwenna, Firas G. Petros, Puneet Sindhwani, Amira Gohara, Evgeny Yakirevich, Mahasin A. Osman   +8 more
wiley   +1 more source

Discovery of kidney disease targets using multimodal human podocyte injury models. [PDF]

Stem Cell Reports
Barreto AD, Jiang B, Burt MA, Dimitrakakis N, Musah S.   +4 more
europepmc   +1 more source