Results 31 to 40 of about 46,505 (249)

MβCD treatment does not prevent correct regional targeting of the axons innervating an identified glomerulus (glomerulus X).

, 2013
Untreated (A–C) and MβCD-treated (D–F) animals. A,B: Stage 7. An antibody to human ankyrin B (yellow) labels ORN axons targeting a single glomerulus located dorso-posteriorly close to primary neurites of the medial cluster of AL neurons (outlined with ...
Nicholas J. Gibson (173220), Leslie P. Tolbert (173221), Lynne A. Oland (173224)   +2 more
core   +1 more source

Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower Atherosclerotic Cardiovascular Disease Risk and Prevent Polypharmacy in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg, Murray Urowitz, Charlie Dentz, Niriti Adhikari, Fauzia Hollnagel, Nathalie Costedoat‐Chalumeau   +5 more
wiley   +1 more source

Microsphere-adenoviral complexes target and transduce the glomerulus in vivo [PDF]

, 2000
Microsphere-adenoviral complexes target and transduce the glomerulus in vivo.BackgroundDeveloping new treatments for glomerulonephritis makes the glomerulus a logical target for gene therapy.
Troike, Anne E., Sedmak, Daniel D., Sferra, Thomas J., Urban, Kathleen E., Kronenberger, Julie, Holycross, Bethany J., Nahman, N. Stanley, Johnson, Amy, Nuovo, Gerard J.   +8 more
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

Sparsened neuronal activity in an optogenetically activated olfactory glomerulus [PDF]

, 2018
© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 14955, doi:10.1038/s41598-018-33021-w.Glomeruli are the functional units ...
Cohen, Lawrence B., Geiller, Tristan, Homma, Ryota, Tombaz, Tuce, Bozza, Thomas, Braubach, Oliver R., Choi, Yunsook   +6 more
core   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Superficial Nephrons in BALB/c and C57BL/6 Mice Facilitate In Vivo Multiphoton Microscopy of the Kidney [PDF]

, 2013
Multiphoton microscopy (MPM) offers a unique approach for addressing both the function and structure of an organ in near-real time in the live animal. The method however is limited by the tissue-specific penetration depth of the excitation laser.
Bardehle, Sophia, Bardehle Sophia, Castrop Hayo, Castrop, Hayo, Schießl, Ina Maria, Hayo Castrop, Schießl Ina Maria, Schießl, I.M., Castrop, H., Ina Maria Schießl, Bardehle, S., Sophia Bardehle   +11 more
core   +2 more sources

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

HUBUNGAN KADAR GLUKOSA DARAH TERHADAP ESTIMASI LAJU FILTRASI GLOMERULUS PADA PASIEN DIABETES MELITUS [PDF]

, 2017
LatarBelakang : Diabetes Melitus adalah penyakit yang ditandai dengan terjadinya hiperglikemia dan gangguan metabolism karbohidrat, lemak, dan protein. Peningkatan kadar glukosa darah pada pasien dibetes mellitus dapat mengakibatkan berbagai komplikasi ...
Adhipireno, Purwanto, Basundoro, Padaka Aji   +1 more
core   +1 more source