Results 51 to 60 of about 46,505 (249)

Profiling and annotation of human kidney glomerulus proteome [PDF]

, 2013
新潟大学博士（医学）Background: The comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes.
50161, Cui, Zhenyu
core  

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Transcriptional profiling of the kidney glomerulus

, 2010
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and infections. It has been shown that
Ying Sun (23237)
core   +1 more source

Towards a Glomerulus Nanoscale Spatial Atlas

, 2022
Thesis (Master's)--University of Washington, 2022The glomerulus is the basic filtration apparatus of the kidney, where thousands of the capillary-rich structures function to remove waste products from the blood stream while retaining macromolecules and ...
Ali, Adilijiang
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Imaging of hydroperoxides in a rat glomerulus stimulated by puromycin aminonucleoside [PDF]

, 1999
Imaging of hydroperoxides in a rat glomerulus stimulated by puromycin aminonucleosideBackgroundTo determine the locus of the increased oxidation induced by puromycin aminonucleoside (PAN), we imaged hydroperoxides in glomeruli stimulated by PAN in vivo ...
Takemura, Katsumi, Ueda, Atsushi, Nagase, Sohji, Akiyama, Kayo, Koyama, Akio, Hirayama, Aki, Narita, Mitsuharu, Gotoh, Mitihiro, Tomida, Chie, Aoyagi, Kazumasa   +9 more
core   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Pengaruh Ekstrak Kulit Tomat terhadap Luas Glomerulus Ginjal Tikus Model Diabetes Melitus Tipe 2 [PDF]

, 2017
Diabetes melitus (DM) tipe 2 merupakan penyakit metabolik yang terjadi karena defek progresif dari sekresi insulin yang didasari oleh resistensi insulin.
Hapsari, Prahita Atyan
core  

Response Characteristics of an Identified, Sexually Dimorphic Olfactory Glomerulus

, 2000
Partitioning of synaptic neuropil into glomeruli is a common feature of primary olfactory centers in most animal species. The functional significance of glomeruli, however, is not yet well understood.
John G. Hildebrand, Jane Roche King, Thomas A. Christensen   +2 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source