Results 11 to 20 of about 576,914 (292)

Glomerulus Classification and Detection Based on Convolutional Neural Networks [PDF]

Journal of Imaging, 2018
Glomerulus classification and detection in kidney tissue segments are key processes in nephropathology used for the correct diagnosis of the diseases. In this paper, we deal with the challenge of automating Glomerulus classification and detection from ...
Jaime Gallego, Anibal Pedraza, Samuel Lopez, Georg Steiner, Lucia Gonzalez, Arvydas Laurinavicius, Gloria Bueno   +6 more
doaj   +2 more sources

Proteolysis and inflammation of the kidney glomerulus. [PDF]

Cell Tissue Res, 2021
AbstractProteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis.
Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM, Wiech T, Rinschen MM.   +7 more
europepmc   +7 more sources

Transcriptional profiling of the kidney glomerulus

, 2010
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and infections. It has been shown that many known glomerular specic/enriched genes play crucial roles in the maintenance of glomerular ...
Ying Sun (23237)
core   +3 more sources

Profiling and annotation of human kidney glomerulus proteome. [PDF]

Proteome Sci, 2013
Abstract Background The comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes. This dataset, however, contained considerable redundancy resulting from identification criteria under which ...
Cui Z, Yoshida Y, Xu B, Zhang Y, Nameta M, Magdeldin S, Makiguchi T, Ikoma T, Fujinaka H, Yaoita E, Yamamoto T.   +10 more
europepmc   +6 more sources

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]

Commun Biol, 2021
The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J, Chesor M, Kuzmuk V, Johnson T, Satchell SC, Welsh GI, Saleem MA.   +6 more
europepmc   +2 more sources

Determinants of Vascular Permeability in the Kidney Glomerulus [PDF]

Journal of Biological Chemistry, 2002
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the human mutations in nephrin, podocin, alpha-actinin-4, COL4A3, and COL4A5 genes
Hamano, Yuki, Grunkemeyer, James A., Sudhakar, Akulapalli, Zeisberg, Michael, Cosgrove, Dominic, Morello, Roy, Lee, Brendan, Sugimoto, Hikaru, Kalluri, Raghu   +8 more
openaire   +3 more sources

Prenatal glomerular changes during development of human foetal kidney

National Journal of Clinical Anatomy, 2016
Background and aims: The cortical glomerulus shows many developmental changes during fetogenesis. Normal histology of the fetal glomerulus at various stages of development was studied to get insight into the morphology of fetal glomerulus.
Roli Joshi, Deepa Deopa, D N Sinha, A K Singh   +3 more
doaj   +1 more source

Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset [PDF]

, 2010
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function.
Clemens D Cohen, Ilka Edenhofer, Felix Eichinger, Rastaldi, Maria P., Maja T. Lindenmeyer, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Eichinger, Felix, Eichinger Felix, Kretzler, Matthias, Mattinzoli, D, Deborah Mattinzoli, Maja T Lindenmeyer, Maria P. Rastaldi, Cohen, Clemens D., Kretzler, M, Sen, Kontheari, Rastaldi Maria P., Matthias Kretzler, Edenhofer, I, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Maria P Rastaldi, Mattinzoli Deborah, Mattinzoli, Deborah, Anders, Hans-Joachim, Sen Kontheari, Kretzler Matthias, Edenhofer, Ilka, Kontheari Sen, Lindenmeyer Maja T., Rastaldi, M P, Edenhofer Ilka, Eichinger, F, Sen, K, Mattinzoli D, Anders HJ, Eichinger F, Lindenmeyer MT, Cohen CD, Sen K, Kretzler M, Rastaldi MP, Edenhofer I   +46 more
core   +1 more source

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Micromachines, 2021
Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye, Rohan Bhattacharya, Xingrui Mou, Yuhao Zhou, Morgan A. Burt, Samira Musah   +5 more
doaj   +1 more source

Evaluation the efficacy of Leea indica leaves aqueous extract against nephrotoxicity induced by Diethylnitrosamine (DEN) in male rats

Journal of Kerbala for Agricultural Sciences, 2023
The aim of this study is to find out the quality of the aqueous extract of leea indica leaves in protecting kidney tissues from oxidative stress caused by DEN.
Mustafa Abd-Alhussein Kazam, Heba A. Abd-Alsalam Alsalame   +1 more
doaj   +1 more source