A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
Micromachines, 2021 Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye +5 more
doaj +3 more sources
Endothelin and the Glomerulus in Chronic Kidney Disease [PDF]
Seminars in Nephrology, 2015 Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is expressed constitutively in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function.
Matthias, Barton, Andrey, Sorokin
openaire +4 more sources
Glomerulus Classification and Detection Based on Convolutional Neural Networks
Journal of Imaging, 2018 Glomerulus classification and detection in kidney tissue segments are key processes in nephropathology used for the correct diagnosis of the diseases. In this paper, we deal with the challenge of automating Glomerulus classification and detection from ...
Jaime Gallego +6 more
doaj +3 more sources
Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing. [PDF]
Kidney Int, 2018 Eng DG +7 more
europepmc +2 more sources
Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus
Journal of Controlled Release, 2017 R. Bruni +7 more
semanticscholar +3 more sources
Large‐scale identification of genes implicated in kidney glomerulus development and function
EMBO Journal, 2006 M. Takemoto +18 more
semanticscholar +3 more sources
Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme [PDF]
, 2013 The renal endothelium has been debated as arising from resident hemangioblast precursors that transdifferentiate from the nephrogenic mesenchyme (vasculogenesis) and/or from invading vessels (angiogenesis).
Bates, CM +7 more
core +14 more sources
Extracellular matrix and vascular dynamics in the kidney of a murine model for Marfan syndrome.
PLoS ONE, 2023 Fibrillin-1 is a pivotal structural component of the kidney's glomerulus and peritubular tissue. Mutations in the fibrillin-1 gene result in Marfan syndrome (MFS), an autosomal dominant disease of the connective tissue.
Rodrigo Barbosa de Souza +8 more
doaj +1 more source
Cells, 2022 Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts have ...
Kimberly S. Collins +14 more
doaj +1 more source
Glycerol Improves Intracerebral Hemorrhagic Brain Injury and Associated Kidney Dysfunction in Rats
Antioxidants, 2021 In stroke patients, the development of acute kidney injury (AKI) is closely linked with worse outcomes and increased mortality. In this study, the interplay between post-stroke and AKI and treatment options was investigated in a rodent model of ...
Cheng-Yi Chang +7 more
doaj +1 more source