Results 51 to 60 of about 432,986 (215)

Primary focal segmental glomerulosclerosis

, 2018
The proportion of cases of primary focal segmental glomerulosclerosis responsive to treatment with corticosteroids is variable and depends on histological type, patient age and duration, and dose of steroid treatment, but overall complete remission rate ...
Alain Meyrier, Patrick Niaudet
core   +2 more sources

Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis [PDF]

, 1999
Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis.BackgroundFamilial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic
Winn, Michelle P., Bembe, Marylou, Gross, Deborah A, Rogala, Allison R, Smith, Anne H, Lynn, Kelvin L., Howell, David N, on behalf of the International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis, on behalf of the International Collaborative Group for the Study of Familial Focal Segmental, Graham, Felicia L., Conlon, Peter J., Vance, Jeffery M, Vance, Jeffery M., Gross, Deborah A., Winn, Michelle P, Conlon, Peter J, Quarles, L. Daryl, Graham, Felicia L, on behalf of the International Collaborative Group for the Study of Familial Focal Segmental Glomerulosclerosis,, Pericak-Vance, Margaret A., Pericak-Vance, Margaret A, Howell, David N., Rogala, Allison R., Lynn, Kelvin L, Smith, Anne H.   +23 more
core   +1 more source

A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic Associations

Kidney Medicine
Focal segmental glomerulosclerosis (FSGS) defines a distinct histologic pattern observed in kidney tissue that is linked to several distinct underlying causes, all converging on the common factor of podocyte injury.
Marco Bonilla, Orhan Efe, H. Selvaskandan, Edgar V. Lerma, Nasim Wiegley   +4 more
semanticscholar   +1 more source

Rituximab in adult minimal change disease and focal segmental glomerulosclerosis - What is known and what is still unknown?

Autoimmunity Reviews, 2020
Primary forms of minimal change disease and focal segmental glomerulosclerosis are rare podocytopathies and clinically characterized by nephrotic syndrome.
P. Gauckler, J. Shin, F. Alberici, V. Audard, A. Bruchfeld, M. Busch, C. Cheung, Matija Crnogorac, Elisa Delbarba, K. Eller, S. Faguer, KRESIMIR Galešić, S. Griffin, Z. Hruskova, A. Jeyabalan, A. Karras, C. King, H. Kohli, R. Maas, G. Mayer, S. Moiseev, M. Muto, Balazs Odler, R. Pepper, L. Quintana, J. Radhakrishnan, R. Ramachandran, A. Salama, M. Segelmark, V. Tesar, J. Wetzels, L. Willcocks, M. Windpessl, L. Zand, Reza Zonozi, A. Kronbichler   +35 more
semanticscholar   +1 more source

COVID-19–Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis

Kidney Medicine, 2020
Coronavirus disease 19 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with acute kidney injury, presumably due to acute tubular injury.
Sandeep Magoon, Prasad Bichu, V. Malhotra, Fatema Alhashimi, Yang-Lin Hu, Siddharth Khanna, Kabaye Berhanu   +6 more
semanticscholar   +1 more source

Study Design of the Phase 3 Sparsentan Versus Irbesartan (DUPLEX) Study in Patients With Focal Segmental Glomerulosclerosis

Kidney International Reports, 2020
Introduction Focal segmental glomerulosclerosis (FSGS), a histologic lesion in the kidney caused by varied pathophysiological processes, leads to end-stage kidney disease in a large proportion of patients.
R. Komers, U. Diva, J. Inrig, A. Loewen, H. Trachtman, W. Rote   +5 more
semanticscholar   +1 more source

COVID-19–Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases

Kidney Medicine, 2020
Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with diverse causes. The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans ...
Yuvraj Sharma, S. Nasr, Christopher P. Larsen, A. Kemper, A. Ormsby, S. Williamson   +5 more
semanticscholar   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Recurrent Focal Segmental Glomerulosclerosis after Renal Transplantation

, 1991
In a young adult male with chronic renal failure from focal segmental glomerulosclerosis, massive proteinuria appeared within two weeks after transplantation.
M. Minz, K.S. Chugh, V. Sakhuja, A.R. Datta, K. Joshi   +4 more
core   +1 more source

Mucin-1 Gene Mutation and the Kidney: The Link between Autosomal Dominant Tubulointerstitial Kidney Disease and Focal and Segmental Glomerulosclerosis

Case Reports in Nephrology, 2018
Glomerular diseases are one of the most frequent causes of chronic kidney disease, focal and segmental glomerulosclerosis being one of the commonest glomerulopathies.
H. Trimarchi, M. Paulero, T. Rengel, I. González-Hoyos, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, A. Iotti   +8 more
doaj   +1 more source