Results 71 to 80 of about 432,986 (215)
JCI Insight, 2020 To define cellular mechanisms underlying kidney function and failure, the Kidney Precision Medicine Project (KPMP) analyzes biopsy tissue in a multi-center research network to build cell-level process maps of kidney.
Rajasree Menon +21 more
semanticscholar +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
The elusive podocyte crossmatch for recurrent focal segmental glomerulosclerosis
, 2019 Focal segmental glomerulosclerosis is a glomerular disorder with a high rate of recurrence. Although kidney biopsies remain the gold standard to diagnose recurrent focal segmental glomerulosclerosis, non-invasive prognostic assays could facilitate ...
Burke, 3rd, George W, Fornoni, Alessia
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys +14 more
wiley +1 more source
Focal Segmental Glomerulosclerosis
Turkish Journal of Nephrology, 2019 Focal segmental glomerulosclerosis (FSGS) is a common histological aspect of glomerular injury due to diverse etiologies. It is the most common cause of end stage renal disease (ESRD) in primary glomerulonephritis.
Erkan ŞENGÜL +2 more
doaj
Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis
Journal of Clinical Periodontology, EarlyView.ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali +5 more
wiley +1 more source
Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children [PDF]
, 1995 Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children. The distribution of lesions of glomerulosclerosis, whether focal or diffuse, has important implications for pathogenesis and potential therapeutic ...
Horn, Sarah L. +3 more
core +1 more source
BMC Nephrology, 2020 Background Mutations in the Wilms tumor 1 gene cause a spectrum of podocytopathy ranging from diffuse mesangial sclerosis to focal segmental glomerulosclerosis.
Daisuke Matsuoka +9 more
doaj +1 more source
MYO1E mutations and childhood familial focal segmental glomerulosclerosis
, 2011 BACKGROUND Focal segmental glomerulosclerosis is a kidney disease that is manifested as the nephrotic syndrome. It is often resistant to glucocorticoid therapy and progresses to end-stage renal disease in 50 to 70% of patients.
Andrea Calabria +77 more
core +1 more source
Emerging drugs for treatment of focal segmental glomerulosclerosis
Expert Opinion on Emerging Drugs, 2020 Background Glomerulosclerosis represents the final stage of glomerular injury during the course of kidney disease and can result from a primary disturbance in disorders like focal segmental glomerulosclerosis or a secondary response to tubulointerstitial
H. Trachtman
semanticscholar +1 more source