Results 101 to 110 of about 19,393 (195)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Podocyte Injury Can Be Catching [PDF]

Journal of the American Society of Nephrology, 2011
Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis ...
openaire   +1 more source

Human podocyte injury in the early course of hypertensive renal injury

World Journal of Clinical Cases, 2019
Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction, outnumbered only by diabetes. However, the mechanisms remain unclear.To investigate podocyte injury induced by hypertension in the early course without massive proteinuria or renal dysfunction.The hypertension group comprised
Sun, Da, Wang, Jiao-Jiao, Wang, Wei, Wang, Juan, Wang, Li-Ning, Yao, Li, Sun, Ying-Hui, Li, Zi-Long   +7 more
openaire   +2 more sources

Targeting YAP1‐Mediated Tubular Cell Senescence to Attenuate Maladaptive Repair and Fibrotic Transition After Acute Kidney Injury

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
YAP1 mediates tubular cell senescence and drives maladaptive repair following AKI, promoting the AKI to CKD transition. Single‐cell RNA‐seq reveals sustained YAP1 overexpression, fibroblast activation, and pro‐fibrotic tubular cell shift. Senolytic agents or verteporfin (YAP1/TEAD1 inhibitor) suppress YAP1 activity, reduce renal senescence, alleviate ...
Zhibo Zhao, Huiping An, Yonghou Sang, Si Chen, Jinxiu Zhou, Tingting Zhang, Junhu Li, Xiaoshuang Zhou   +7 more
wiley   +1 more source

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease.

PLoS ONE, 2011
Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran, Rikke Nielsen, Jakob V Larsen, Søren S Sørensen, Ulla Feldt-Rasmussen, Moin A Saleem, Claus M Petersen, Pierre J Verroust, Erik I Christensen   +8 more
doaj   +1 more source

Hodgkin's Lymphoma Presenting With Nephrotic Syndrome and Complicated by Posterior Reversible Encephalopathy Syndrome in a Child: A Rare Multisystem Interaction

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Early recognition of nephrotic syndrome and neurological complications in pediatric Hodgkin's lymphoma is essential. This case highlights a rare association between Hodgkin's lymphoma, nephrotic syndrome, and posterior reversible encephalopathy syndrome, emphasizing the importance of multidisciplinary management and prompt blood pressure ...
Balqees Al‐Shohef, Majd Hamed Nasser, Hind Alhiraki, Sameer Baqla, Othman Hamdan, Mona Hussein   +5 more
wiley   +1 more source

Oxidative Stress‐Induced Expression Levels of PXDN and NF‐κB in Type 2 Diabetic Patients With Nephropathy

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
PXDN expression is markedly upregulated in diabetic nephropathy and, versus NF‐κB and oxidative stress markers, shows superior diagnostic performance (AUC 0.79; 90% specificity), supporting PXDN as a sensitive, specific non‐invasive biomarker for early DN.
Zakira Hanin, Aisha Anees Ahmed, Shuhd Salem Al Nahdi, Sumayya Althaf Kasim, Mahir Khalil Jallo, Rajaram Rhambau Jagdale, Dalia A. Gaber   +6 more
wiley   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

Association of Triglyceride‐Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension

The Journal of Clinical Hypertension, Volume 28, Issue 7, July 2026.
ABSTRACT We aimed to examine the association between insulin resistance (IR) and target organ damage (TOD) in patients with hypertension. Three indices of IR (Triglyceride‐Glucose index: TyG; triglyceride‐to‐HDL ratio: TG/HDL‐C; Metabolic Score for Insulin Resistance: METS‐IR) were examined for their association with TOD in 614 newly diagnosed patients
Ionas Papasotiriou, Anastasios Tentolouris, Sotiria Spiliopoulou, Theodoros N. Sergentanis, Efstathios Manios   +4 more
wiley   +1 more source