Results 101 to 110 of about 29,045 (218)

LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA

Journal of Diabetes Investigation, EarlyView.
LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang, Zixu Huang, Xiaohui Kuang, Yali Nan, Zhiwen Zhang, Zongming Song   +5 more
wiley   +1 more source

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner [PDF]

, 2015
ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair ...
Ashrafi, Bahn, Benzing, Botto, Bruno, Burckhardt, Caricchio, Elliot, Fukatsu, Garibotto, Goldschmeding, Golestaneh, Hellmark, Huang, Hurn, Karl, Kibbe, Koren, Koya, LeBlanc, Manabe, Matsumura, Matsumura, Moeckel, Nardulli, Nishinakagawa, Obrosova, Oh, Ortiz, Pacher, Padanilam, Padanilam, Padanilam, Patrick, Paz-Elizur, Pioli, Ponticelli, Povey, Price, Reckelhoff, Roth, Samson, Samson, Samson, Samson, Schwartz, Shankland, Silbiger, Silbiger, Skinner, Suszták, Suzuki, Szabo, Virág, Wagner, Warrens, Weber, Wiggins, Wilson, Wilson, Woolf, Yang, Zagonel, Zucker   +63 more
core   +2 more sources

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease.

PLoS ONE, 2011
Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran, Rikke Nielsen, Jakob V Larsen, Søren S Sørensen, Ulla Feldt-Rasmussen, Moin A Saleem, Claus M Petersen, Pierre J Verroust, Erik I Christensen   +8 more
doaj   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Urinary exosomes aggravate diabetic kidney disease by inducing podocyte ferroptosis via the miR‐217/SIRT1/Nrf2 pathway

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
These findings indicate that urinary exosomal miR‐217 promotes podocyte ferroptosis and DKD progression via suppression of the SIRT1/Nrf2 pathway, suggesting a potential therapeutic target for DKD. Abstract Urinary exosomal microRNAs (miRNAs) mediate intercellular communication in diabetic kidney disease (DKD), a leading contributor to end‐stage renal ...
Xin Du, Yubo Jiang, Hongbin Guo, Haiying Zhang, Shaoqing Wang, Hao Deng, Xinyi Huang, Xiu Li   +7 more
wiley   +1 more source

A case report of adrenocorticotropic hormone to treat recurrent focal segmental glomerular sclerosis post-transplantation and biomarker monitoring [PDF]

, 2015
Background: Recurrent focal segmental glomerular sclerosis (rFSGS) in renal transplant recipients (RTR) is difficult to predict and treat. Early rFSGS is likely from circulating factors and preformed antibodies.
Anwar, Siddiq, Ashraf, Muhammad, Brennan, Daniel C, Culiberk, Nancy, Larson, Derek S, Liapis, Helen, Naimi, Nimi, Reiser, Jochen, Wei, Changli   +8 more
core   +4 more sources

Beyond Preeclampsia: Focal and Segmental Glomerulosclerosis Presenting as Nephrotic‐Range Proteinuria During Pregnancy, A Clinical Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Nephrotic‐range proteinuria during pregnancy is not always preeclampsia. This case illustrates a steroid‐responsive tip‐variant podocytopathy with normal angiogenic biomarkers (sFlt‐1/PlGF), supporting a non‐placental origin. Renal biopsy confirmed the diagnosis, while concurrent CMV infection may have acted as a potential immunologic trigger ...
Sierra Acuña Ximena Rosario, Camarena Pulido Eva Elizabet   +1 more
wiley   +1 more source

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham, Leja Hamza, Azeb Kebede, Daniel Rebuma Bekele, Zekarias Amdemariam   +4 more
wiley   +1 more source