Results 111 to 120 of about 899,728 (258)

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Rhein attenuates obesity-related glomerulopathy by inhibiting the P2X7R/NLRP3 inflammasome pathway and protecting podocytes [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To investigate the renoprotective effects of Rhein in obesity-related glomerulopathy (ORG) by inhibiting the P2X7 receptor (P2X7R)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway.Materials and Methods: ORG was induced in C57BL/6J ...
Lifang Wei, Jinwen Zhang, Liangding Dou, Xiaoxin Wu, Minmin Xu, Jinxia Ye, Yanyan Yang, Yongxing Zhang, Shaojian Xiao   +8 more
doaj   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Injury-induced paracrine effects on the podocyte’s transcriptome

American Journal of Physiology-Renal Physiology
From a clinical perspective, it is ideal if yet unknown common pathways could be therapeutically targeted in different forms of injury in diseases of podocytes, and if there were mitigation strategies to minimize further damage to yet unaffected podocytes.
Zeng, Yuting, Schweickart, Allen, Sharara, Jana, Maggiore, Joseph, Loretz, Carol, Hukriede, Neil, Pippin, Jeffrey, Theberge, Ashleigh, Wessely, Oliver, Shankland, Stuart   +9 more
openaire   +2 more sources

p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction

, 2018
Mitochondrial dysfunction is increasingly recognized as an important factor in glomerular diseases. Previous study has shown that mitochondrial fission contributed to mitochondrial dysfunction.
Hui Wang, Min Zhao, Aiqing Zhang, Suyan Duan, Lin Wu, Xi Liu, Jia Qi, Chengning Zhang, Yanggang Yuan, Zhimin Huang, Changying Xing, Bo Zhang, Aihua Zhang   +12 more
core   +1 more source

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source

Kaempferol Inhibits Inflammation via Regulating the PI3K/Akt/Nuclear Factor Kappa B Pathway and Promotes Autophagy by Regulating the PI3K/Akt/Mammalian Target of Rapamycin Pathway to Improve Podocyte Injury Induced By Antibody in Lupus Nephritis

World Journal of Traditional Chinese Medicine
Objective: This study aimed to explore the protective effects of kaempferol against podocyte injury in lupus nephritis (LN) and its underlying mechanism.
Jian-Bo Song, Li-Qin Zhao, Yuan-Ping Li, Hong-Ping Wen   +3 more
doaj   +1 more source

Oleanolic Acid‐Enriched Olive Oil Attenuates Kidney Function Decline in Patients With Type 2 Diabetes: Results From the OLTRAD Randomised Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus (T2DM), driven in part by oxidative stress and the accumulation of advanced glycation end products (AGEs). Oleanolic acid (OA), a natural triterpene present in olive‐derived matrices, may modulate AGE metabolism.
Aída García‐González, Alejandro Matamoros‐Domínguez, Juan Manuel Espinosa‐Cabello, Gisela Pérez‐Muñoz, Manuel Jesús León Aranda, María Del Carmen Roque‐Cuellar, Silvia García‐Rey, Andrés Jiménez‐Sánchez, Antonio Jesús Martínez‐Ortega, Miguel Ángel Mangas‐Cruz, Isabel Cerrillo, Javier S. Perona, Pedro Pablo García‐Luna, Elena María Yubero‐Serrano, José María Castellano   +14 more
wiley   +1 more source

Human podocyte injury in the early course of hypertensive renal injury

World Journal of Clinical Cases, 2019
Hypertension is prevalent in the general population and is regarded as the second leading cause of renal damage and dysfunction, outnumbered only by diabetes. However, the mechanisms remain unclear.To investigate podocyte injury induced by hypertension in the early course without massive proteinuria or renal dysfunction.The hypertension group comprised
Sun, Da, Wang, Jiao-Jiao, Wang, Wei, Wang, Juan, Wang, Li-Ning, Yao, Li, Sun, Ying-Hui, Li, Zi-Long   +7 more
openaire   +2 more sources

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source