Results 111 to 120 of about 19,393 (195)

Effect of N-acetyl-seryl-aspartyl-lysyl-proline on high glucose-induced podocyte injury

Linchuang shenzangbing zazhi, 2018
Objective To investigate the effect of N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) on podocyte injury induced by high glucose and its possible mechanisms.Methods The conditionally immortalized mouse podocytes were treated by high glucose with or ...
ZHA Dong-qing, GAO Ping, WU Xiao-yan
doaj  

Compartment‐Specific Immune Remodeling of Renal Aging With C1q‐Associated Podocyte Activation

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Aging repatterns the renal immune response in a compartment‐specific manner, distinct from chronic kidney disease (CKD) adaptation. Glomerular aging features C1q‐associated podocyte activation and macrophage engagement, whereas tubulointerstitial aging is marked by B‐cell aggregation and tertiary lymphoid structure expansion.
Ju‐Young Moon, Kyuwon Shim, Hyun Ji Lim, Dae‐Kyu Kim, Young Yoon Moon, Su‐Woong Jung, Yang‐Gyun Kim, Hyuno Kang, Tae‐Hoon Lee, Jae‐Hyung Lee, Sang‐Ho Lee   +10 more
wiley   +1 more source

Role of the podocyte in glomerular injury

Hong Kong Journal of Nephrology, 2001
INTRODUCTION: Appreciation of the important role of the glomerular epithelial cell or podocyte in glomerular physiology and pathology has accelerated in recent years because of advances in two areas. First, detailed study of a number of rare syndromes of earlyonset nephrotic syndrome has led to the identification of key genes whose protein products are
openaire   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source

Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway

Renal Failure
Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes mellitus. Although studies have indicated the therapeutic potential of mesenchymal stem cells (MSCs) for DKD, the underlying molecular mechanisms remain unclear ...
Honghong Liu, Jiao Wang, Guanru Yue, Jixiong Xu   +3 more
doaj   +1 more source

DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1

Cell Communication and Signaling
Background Podocyte injury causes proteinuria and accelerates glomerular sclerosis during diabetic kidney disease (DKD). Disruptor of telomeric silencing 1-like (DOT1L), an evolutionarily conserved histone methyltransferase, has been reported in ...
Yepeng Hu, Shu Ye, Jing Kong, Qiao Zhou, Zhe Wang, Yikai Zhang, Han Yan, Yaqiong Wang, Tiekun Li, Yi Xie, Bingbing Chen, Yiming Zhao, Tianyue Zhang, Xianan Zheng, Junjia Niu, Bibi Hu, Shengyao Wang, Zhida Chen, Chao Zheng   +18 more
doaj   +1 more source

MicroRNAs for podocyte injury in diabetic nephropathy [PDF]

Annals of Translational Medicine, 2021
openaire   +2 more sources

Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury

Nature Communications
Recent studies have shown the crucial role of podocyte injury in the development of diabetic kidney disease (DKD). Deubiquitinating modification of proteins is widely involved in the occurrence and development of diseases.
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang   +11 more
doaj   +1 more source

Cholesterol and podocyte injury [PDF]

Nature Reviews Nephrology, 2013
openaire   +1 more source

Focal Podocyte Injury [PDF]

, 2020
openaire   +1 more source