Results 131 to 140 of about 29,045 (218)

Role of Podocyte in Kidney Disease

Frontiers in Bioscience-Landmark
Podocytes are epithelial cells lining the outer surface of the renal glomerular capillaries and they play a pivotal role in maintaining the structural and functional integrity of the glomerular filtration barrier.
Sufia Husain
doaj   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury

Nature Communications
Recent studies have shown the crucial role of podocyte injury in the development of diabetic kidney disease (DKD). Deubiquitinating modification of proteins is widely involved in the occurrence and development of diseases.
Ying Zhao, Shijie Fan, Hong Zhu, Qingqing Zhao, Zimin Fang, Diyun Xu, Wante Lin, Liming Lin, Xiang Hu, Gaojun Wu, Julian Min, Guang Liang   +11 more
doaj   +1 more source

Characterization of NLRP3 Inflammasome‐Associated Hub Genes in the Progression of Diabetic Nephropathy

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao, Yuejiao Li, Wenchuan Li, Lan Dong, Rong Lian, Qingqing Luo, Xingji Lian, Jianbo Li, Feng He   +8 more
wiley   +1 more source

New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]

, 2010
Turner, Neil, Zhou, Y. S.
core   +1 more source

Magnetic‐Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Mag‐SELEX identified the first aptamer targeting migrasome, offering a potential ligand for their identification and detection in clinical samples. The magnetic aptamer probe, characterised by high specificity and rapid recovery, provides a simple, rapid, and economical method for elucidating migrasome mechanisms in disease and facilitating ...
Yixin Xu, Lin Jiao, Qiangying Yi, Yuzuo Chen, Bei Cai, Junlong Zhang, Zhuochun Huang, Yao Luo, Yanjun Si, Yao Wu, Binwu Ying, Jie Chen, Juan Zhou   +12 more
wiley   +1 more source

Identification and characterization of novel glomerulus-associated genes and proteins [PDF]

, 2010
The kidney is responsible for sieving the circulating blood to eliminate water-soluble waste products and potentially toxic substances from the body. The filtration step occurs in specialized filtration units called glomeruli.
Xiao, Zhijie
core  

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Effect of empagliflozin on urinary albumin excretion and hypoxic biomarkers in early diabetic kidney disease: A randomised double‐blind, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2978-2987, April 2026.
Abstract Aims The precise mechanism of sodium glucose co‐transporter 2 (SGLT2) inhibitor on reno‐protective effect has been still unclear. In this study, we hypothesised that SGLT2 inhibitor prevents diabetic kidney disease via reduction of hypoxia‐induced factors.
Hisashi Makino, Masato Kasahara, Ryuzo Takashima, Shu Kasama, Naoki Ozu, Hyohun Park, Qingxing Chen, Kazuhiko Tsuruya, Mayu Tochiya, Yoko Omura‐Ohata, Tamiko Tamanaha, Michio Noguchi, Takeshi Aiba, Fumiki Yoshihara, Kiminori Hosoda   +14 more
wiley   +1 more source