Results 151 to 160 of about 899,728 (258)

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

Autophagy-Related Alterations Associated with AMPK–mTOR Signaling in Podocyte Injury During Obstructive Cholestasis

Obstructive cholestasis is increasingly recognized to induce renal injury beyond the liver, yet the mechanisms underlying cholestasis-associated glomerular damage remain poorly defined.
Yicong Zong, Chao Ma, Xianglong Ge, Boyu Kong, Shuo Zhao, Xiaoyu Wang, Yu Wang, Yixiang Zhang, Lin Lyu   +8 more
core   +1 more source

Sarsasapogenin Preserves Podocyte Integrity and Attenuates Renal Injury in Experimental IgA Nephropathy

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Experimental IgA nephropathy leads to renal inflammation, fibrosis, podocyte injury, and impaired renal function. Sarsasapogenin treatment attenuated inflammatory and profibrotic signaling, reduced extracellular matrix accumulation, preserved nephrin and podocin expression, improved podocyte ultrastructure, and ameliorated renal histopathological ...
Meltem Kumaş, Dilek Canlar Akar, Mehmet Gül, Erkan Karadaş, Selen Kum Özşengezer, Kadri Kulualp, Orhan Yavuz, Osman Yilmaz   +7 more
wiley   +1 more source

FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury

JCI Insight
Transcriptional reprogramming has an important role in kidney glomerular disease. Using in vivo murine models of podocyte injury, we studied the roles of the FOXC2 and WT1 transcription factors (TFs) in podocyte injury.
Sandrine Ettou, Anya Greenberg, Sangyoon Lee, Arjun Rajesh, Liang Sun, Nahid Tabibzadeh, Haruka Oishi, Ran Konoe, Phillip J. McCown, Sean Eddy, Victoria Driscoll, Tomoya Miyoshi, Ken Hiratsuka, Jason Lam, R. Sathish Srinivasan, Youngsook L. Jung, Biju Isaac, Mingwei Sun, Mary E. Taglienti, Keith Keller, Hong Chen, Matthias Kretzler, Astrid Weins, Ryuji Morizane, Shira Rockowitz, Valerie A. Schumacher, Dongwon Lee, Jordan A. Kreidberg   +27 more
doaj   +1 more source

Vascularization of Human iPSC‐Derived Kidney Organoids Using Perfusion Culture, Pre‐Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix

Advanced Healthcare Materials, Volume 15, Issue 33, 4 September 2026.
An integrated perfusion‐based culture platform combining pre‐vascularized collagen scaffolds, stromal vascular fraction cells, and kidney decellularized extracellular matrix promotes vascularization of human iPSC‐derived kidney organoids. The platform provides evidence of interactions between vascular networks and glomerular‐like structures and enables
Helen Kearney, Andrea Mazzoleni, Ivan Martin, Lorenzo Moroni, Manuele Giuseppe Muraro, Carlos Mota   +5 more
wiley   +1 more source

Cholesterol and podocyte injury [PDF]

Nature Reviews Nephrology, 2013
openaire   +1 more source

Di(2‐Ethylhexyl) Phthalate Exposure and Risk of Diabetic Kidney Disease: Epidemiological Association and Mechanistic Insights

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Objective This study aims to explore the association between exposure to di‐(2‐ethylhexyl) phthalate (DEHP) and diabetic kidney disease (DKD), and to elucidate its potential molecular mechanisms. The study findings provide scientific evidence for the prevention and control of environmental risk factors related to DKD.
Dapeng Yin, Yan Li, Wei Wu, Xiaojuan Wang, Junhua He, Yikun Zhu, Jin Li   +6 more
wiley   +1 more source

Association Between Serum Homocysteine and Chronic Kidney Disease Severity in Vietnamese Outpatients With Type 2 Diabetes: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
In 201 Vietnamese adults with Type 2 diabetes, higher serum homocysteine was associated with CKD and showed a stronger relationship with filtration markers than with albuminuria. Its discrimination of CKD status was moderate‐to‐good (AUC 0.79), while the 11.35 μmol/L threshold requires external validation.
Loi Ngoc Ho, Tien Van Tran, Tinh Trung Truong Tran, Nhan Trong Le, Loc Huu Quach, Khanh Minh Thanh, Hien Ngoc Tran, Hang Khanh Hoang, Ha Hai Tran, Tuan Quoc Le   +9 more
wiley   +1 more source

Role of Thioredoxin Interacting Protein in Nicotine-Induced Podocyte Injury

Cigarette smoking is a well-established risk factor responsible for a broad spectrum of diseases and is the leading cause of preventable deaths globally.
Shah, Shimonee
core  

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source