Results 171 to 180 of about 899,728 (258)

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity

MedComm, Volume 7, Issue 9, September 2026.
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu, Yixuan Sheng, Yun Chang, Yuan Chang, Miaomiao Xu, Wenjing Zhou, Wenxiu Wang, Qingyuan Liao, Zhan Shi, Meng Zhang, Feng Lan, Jiangping Song, Xiaoyan Qiu   +12 more
wiley   +1 more source

A new brake on podocyte injury: ATOH8 meets TGF-β. [PDF]

Am J Physiol Renal Physiol
Shankland SJ, Wessely O.
europepmc   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Macroanatomical, Histological, Histochemical and Ultrastructural Characterisation of the Kidney in the Aksaray Malakli Dog: First Comprehensive Renal Morphological Study of the Breed

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study provides the first comprehensive macroanatomical, histological, histochemical and scanning electron microscopic characterisation of the kidney in the Aksaray Malaklı dog. Key findings include normal canine renal architecture, absence of acidic polysaccharides, PAS‐positive basement membranes, and a previously unreported breed‐specific ...
Hatice Yaren Kuloğlu, Işık Tuncer, Ramazan İlgün, Kenan Erdoğan   +3 more
wiley   +1 more source

Lipid metabolism drives podocyte injury in diabetic kidney disease. [PDF]

Front Immunol
Shang J, Zeng Z, Chai S, Lv X, Han X, Ma B, Xu Y, Wang R, Lv Z.   +8 more
europepmc   +1 more source

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long‐Term High‐Fat Diet

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar, Adebowale Adebiyi   +1 more
wiley   +1 more source

The ELAVL1-PLAUR-suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation. [PDF]

J Diabetes
Xu D, Xu L, Li L.
europepmc   +1 more source

The Human PNPLA3I148M Polymorphism Alters the Renal Kinome and Transporters to Cause Hyperfiltration and Hypertension

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
The present study used mice carrying the I148M polymorphism in the human Patatin‐like phospholipase domain‐containing protein 3 (PNPLA3I148M) to determine the role of this polymorphism in regulating blood pressure and renal filtration. Kinome analysis revealed that male PNPLA3I148M mice exhibited decreased phosphorylation of protein kinase c alpha ...
Gertrude Arthur, Michael I. Adenawoola, Sally Wahba, Bentley S. Montgomery, Claire B. Wingfield, Zachary A. Kipp, Terry D. Hinds Jr., David E. Stec   +7 more
wiley   +1 more source

Elevated Prorenin Induces Podocyte Injury and Glomerular Fibrosis in cyp1a1-Prorenin Transgenic Rats. [PDF]

Int J Mol Sci
Gu C, Liu X, Wu J, Huang Y.
europepmc   +1 more source

Insights Into the Interplay Between the Senescent Cells and Immune Cells

Aging Cell, Volume 25, Issue 9, September 2026.
Kidney aging is associated with increased proximal tubular senescence and leukocyte infiltration. Senolytic treatment reduces senescent cell burden and overall immune cell infiltration. However, macrophages remain enriched around residual senescent cells.
Martin Jaros, Marco Schmidt, Lavinia Neubert, Jan‐Christopher Kamp, Sibylle von Vietinghoff, Jan Hinrich Bräsen, Roland Schmitt, Anette Melk   +7 more
wiley   +1 more source