Results 171 to 180 of about 19,393 (195)

BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury

American Journal of Physiology-Renal Physiology, 2007
In early diabetic renal injury, there is podocyte drop-out (but no decrease in the number of other glomerular cells) which is thought to cause glomerular proteinuria and subsequent diabetic glomerular injury. We tested the hypothesis that early diabetic podocyte injury is caused, in part, by downregulation of bone morphogenetic protein-7 (BMP7) and ...
Grace M, Mitu, Shinong, Wang, Raimund, Hirschberg   +2 more
openaire   +2 more sources

Role of Podocyte Injury in IgA Nephropathy

2013
IgA nephropathy (IgAN) encompasses different pathological entities, all of which are characterized by the mesangial deposition of IgA. Aberrantly glycosylated IgA molecules appear to play a major role in the pathogenesis of IgAN. Both genetic and environmental factors contribute to the formation of IgG antibodies that binds to aberrantly glycosylated ...
Madhav C, Menon, Peter Y, Chuang, John Cijiang, He   +2 more
openaire   +2 more sources

Role of Mitochondria in Podocyte Injury

2014
Mitochondria are cellular organelles that produce the energy required for cellular processes through synthesis of adenosine triphosphate (ATP). They also contribute to a wide range of cellular functions, including reactive oxygen species (ROS) generation, calcium homeostasis, and induction of apoptosis. Mitochondria also contain their own DNA, known as
Yanggang Yuan, Songming Huang, Aihua Zhang   +2 more
openaire   +1 more source

Cell Cycle and Podocyte Injury

2014
Background: The cell cycle is regulated by cyclins activating cyclin-dependent kinases (Cdk). Cdk inhibitors bind to and inhibit cyclin-Cdk complexes.
Henning Hagmann, Stuart J. Shankland, Paul T. Brinkkoetter   +2 more
openaire   +1 more source

Sirtuins as novel pharmacological targets in podocyte injury and related glomerular diseases

Biomedicine and Pharmacotherapy, 2022
Tongtong Liu, Huimin Mao, Yuyang Wang
exaly  

Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury

Molecular Biology Reports, 2022
Yajie Zhao, Gaoting Qu, Shanwen Li
exaly  

ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy

International Journal of Molecular Sciences, 2023
Shicong Song, Sirui Liu, Wei Zou
exaly  

CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy

Biomedicine and Pharmacotherapy, 2023
Zhaohong Chen
exaly  

EGR1 Is an Injury Marker in Podocytes

Journal of the American Society of Nephrology, 2021
Masahiro Okabe, Nobuo Tsuboi, Taiji Matsusaka, Takashi Yokoo   +3 more
openaire   +1 more source

Reduction of anaerobic glycolysis contributes to angiotensin II-induced podocyte injury with foot process effacement

Kidney International, 2023
Zhaowei Chen, Zijing Zhu, Zilv Luo
exaly