Results 161 to 170 of about 19,393 (195)
RETRACTION: Cosentyx Alleviates Psoriasis-Induced Podocyte Injury by Inhibiting the TLR/NF-κB Signaling Pathway. [PDF]
Skin Res Technoleuropepmc +1 more source
Protocatechuic aldehyde ameliorates high glucose-induced podocyte injury by attenuating inflammation, oxidative stress, and apoptosis <i>via</i> suppression of endoplasmic reticulum stress through the GSK3β/Nrf2 pathway. [PDF]
Front Cell Dev BiolWang Y, Wang H, Li Y.
europepmc +1 more source
Urinary detection of podocyte injury
Biomedicine and Pharmacotherapy, 2007 Glomerular epithelial cell (podocyte) biology has been focused on in the last few years. The emerging understanding in podocyte biology has improved the molecular mechanism knowledge in many glomerular diseases. Urinary podocyte count and measurement of urinary podocyte specific markers (nephrin and podocalyxin) have been developed to detect podocyte ...
Marcello Camici
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Podocyte injury and its consequences [PDF]
Kidney International, 2016 Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends on their highly differentiated postmitotic phenotype, which also defines the particular vulnerability of the glomerulus. Recent podocyte biology and gene disruption studies in vivo indicate a causal relationship between abnormalities of single podocyte ...
Michio Nagata
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Aldosterone and glomerular podocyte injury
Clinical and Experimental Nephrology, 2008Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis by acting on the distal nephron. Accumulating evidence suggests that aldosterone also plays pathogenetic roles in cardiovascular and renal injury. For example, aldosterone is a potent inducer of proteinuria.
Miki, Nagase, Toshiro, Fujita
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Urinary Biomarkers of Podocyte Injury
Biomarkers in Medicine, 2008Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary podocyte-specific molecules (including
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Immunohistochemical and urinary markers of podocyte injury
Pediatric Nephrology, 1998Renal podocytes play an important role in glomerular filtration. We estimated podocyte injury by light microscopic examination of kidney specimens or by urinary excretion of substances related to podocytes. Fresh kidney sections from 69 patients and urinary sediments from 84 patients with various renal diseases were examined immunohistochemically using
M, Hara +4 more
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Podocyte injury and targeting therapy: an update
Current Opinion in Nephrology & Hypertension, 2006Podocyte injury is a central event in the development of glomerulosclerosis. This review highlights contributions from the past year to our understanding of mechanisms of podocyte injury and implications for potential treatment strategies of glomerular disease.Rearrangement of the actin cytoskeleton, the backbone linking the slit diaphragm, apical ...
Raghu V, Durvasula, Stuart J, Shankland
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Podocyte Injury and Glomerulosclerosis in Hyperhomocysteinemic Rats
American Journal of Nephrology, 2007<i>Background/Aims:</i> We previously reported that increase in plasma homocysteine (Hcys) levels by a 6-week methionine treatment produced remarkable glomerular injury. However, the mechanism by which hyperhomocysteinemia (hHcys) produces glomerular injury remains unknown.
Fan, Yi +5 more
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2014
Background: The podocyte is central to the glomerular filtration barrier and is particularly important in the disease process of focal segmental glomerulosclerosis (FSGS). The podocyte is injured in two main ways in idiopathic nephrotic syndrome. The first is by single gene disorders, such as NPHS1, NPHS2, CD2AP and TRPC6, which has led to a focus on ...
Wen Yi Ding, Moin A. Saleem
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Background: The podocyte is central to the glomerular filtration barrier and is particularly important in the disease process of focal segmental glomerulosclerosis (FSGS). The podocyte is injured in two main ways in idiopathic nephrotic syndrome. The first is by single gene disorders, such as NPHS1, NPHS2, CD2AP and TRPC6, which has led to a focus on ...
Wen Yi Ding, Moin A. Saleem
openaire +1 more source