Results 181 to 190 of about 899,728 (258)

Immune podocyte injury in autoimmune glomerular diseases. [PDF]

Front Immunol
Zhu H, Sun J, Yan Y, Liu P, Huang Y.
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Enhanced WWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119. [PDF]

Int J Biol Sci
You R, Jiang Y, Xu Y, Liu Q, Gu M, Zhang Y, Jia Z, Wu M, Bai M, Zhang A.   +9 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

Immunology &Cell Biology, Volume 104, Issue 8, Page 783-793, September 2026.
UCHL1‐associated pathology. The pathological role of UCHL1 in multisystem diseases, including cancer, neurological, musculoskeletal and cardiovascular disorders. ABSTRACT Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of ...
Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan   +3 more
wiley   +1 more source

Nanotechnology-mediated podocyte injury repair: mechanistic exploration and therapeutic prospects. [PDF]

Ren Fail
Zhu H, Liang P, Liu H, Chen S, Liang G.
europepmc   +1 more source

Successful Control of Late‐Onset Nephrotic Syndrome in FN1‐Associated Fibronectin Glomerulopathy: A 17‐Year Clinical Course

Nephrology, Volume 31, Issue 9, September 2026.
ABSTRACT Fibronectin glomerulopathy (FNG) is a rare renal disorder characterized by excessive glomerular fibronectin deposition, often associated with variants in the fibronectin 1 (FN1) gene. Clinically, FNG presents with proteinuria, hematuria, and hypertension, and may progress to end‐stage kidney disease.
Nobuhiro Kanazawa, Masayuki Iyoda, Kazuki Abe, Taihei Suzuki, Yoko Shirai, Kenichiro Miura, Kazuho Honda, Hirokazu Honda   +7 more
wiley   +1 more source

The Src‐Family Kinases Hck, Fgr and Lyn Drive Immune Complex‐Mediated Glomerulonephritis Through the Syk Tyrosine Kinase

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lukács S. Lesinszki, Dorottya Deli, Lili K. Boldizsár, Áron Pánczél, Attila Fintha, Michael G. Robson, Attila Mócsai   +6 more
wiley   +1 more source

Integrated transcriptomic analysis of LMB2-induced podocyte injury identifies conserved inflammatory and adaptive stress responses. [PDF]

PLoS One
Esmaeili MR, Nejati M, Roqanian S, Moghadasali R, Taleahmad S.   +4 more
europepmc   +1 more source

Integrating Tissue Proteomics and Urinary Analyses to Capture Dynamic Podocyte Injury. [PDF]

Kidney Int Rep
Kajana X, Caridi G, Angeletti A.
europepmc   +1 more source