Results 91 to 100 of about 899,728 (258)

Podocyte Injury Can Be Catching [PDF]

Journal of the American Society of Nephrology, 2011
Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis ...
openaire   +1 more source

Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition [PDF]

, 2016
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria.
van der Vlag, Johan, Dijkman, Henry B, Andrea M. Isidori, Berden, Jo H, Nijenhuis, Tom, Berden, J.H., ISIDORI, Andrea, Carole Henique, Henique, C., Johan van der Vlag, Joost G. Hoenderop, Tom Nijenhuis, Dijkman, H.B.P.M., Tharaux, P.L., Hoenderop, J.G.J., Isidori, A.M., Ramon Sonneveld, Vlag, J. van der, Pierre-Louis Tharaux, Sonneveld, Ramon, Henique, Carole, Henry B. Dijkman, Jo H. Berden, Hoenderop, Joost G, Sonneveld, R., Nijenhuis, T., Tharaux, Pierre Louis   +26 more
core   +2 more sources

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Influence of Podocyte Injury on the Development of Class IV Lupus Nephritis [PDF]

Cyntia Camilo Franco Borges Zago,1 Bruna de Freitas Oliveira,1 Giovanna Uehara,1 Ana Laura Carvalho da Silva,1 Laura Penna Rocha,1 Fabiano Bichuette Custódio,2 Liliane Silvano Araújo,1 Crislaine Aparecida da Silva,1 Marlene Antônia Reis,1 Juliana Reis ...
Zago CCFB, Uehara G, Reis MA, Custódio FB, Oliveira BDF, Rocha LP, Araújo LS, da Silva CA, Machado JR, da Silva ALC   +9 more
core  

Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy

, 2023
Contains fulltext : 300150.pdf (Publisher’s version ) (Open Access)SIGNIFICANCE STATEMENT: Autophagy protects podocytes from injury in diabetic kidney disease (DKD).
Daan C. ‘t Hart, Delbet, Jean-Daniel, van der Vlag, Johan, Karras, A., Rabant, Marion, Ryuta Sato, Salemkour, Y., Karras, Alexandre, Olivia Lenoir, Dilemin Yildiz, Nijenhuis, Tom, Mahtal, Nassim, Jean-Daniel Delbet, Nassim Mahtal, Yildiz, Dilemin, Johan van der Vlag, Dionet, Léa, Emmanuel Letavernier, Tom Nijenhuis, Hart, D.C. 't, Alexandre Karras, Verheijden, K.A.T., Saito, R., Tharaux, P.L., Letavernier, E., Verheijden, Kim A.T., Yann Salemkour, Kim A.T. Verheijden, ‘t Hart, Daan C., Rabant, M., Léa Dionet, Lenoir, O., Saito, Ryuta, Mahtal, N., Pierre-Louis Tharaux, Vlag, J. van der, Delbet, J.D., Yildiz, D., Letavernier, Emmanuel, Lenoir, Olivia, Nijenhuis, T., Salemkour, Yann, Tharaux, Pierre-Louis, Marion Rabant, Dionet, L.   +44 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Store-Operated Calcium Entry and Podocyte Injury in Diabetic Nephropathy [PDF]

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Proteinuria/albuminuria is not only the early clinical manifestation of DN, but also exacerbates kidney injury in DN and is associated with the mortality and cardiovascular event ...
Tao, Yu
core   +1 more source

Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage

Cellular Physiology and Biochemistry, 2018
Background/Aims: Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation ...
Zhi Zuo, Jian-Xiao Shen, Yan Pan, Juan Pu, Yong-Gang Li, Xing-hua Shao, Wan-Peng  Wang   +6 more
doaj   +1 more source

Podocyte-specific FcRn KO resulted in a significant increase in intraglomerular IgG accumulation, but no change in albumin accumulation.

, 2019
A, Intraglomerular IgG: At 3 months of age, there was no significant difference in IgG accumulation between podocyte specific FcRn KO (fl/fl; cre/+) and control mice (fl/fll;+/+). (n = 3 mice per group).
Linda Lewis (6407513), Judith Blaine (277407), Pantipa Tonsawan (6407516), Parmjit S. Jat (634721), Makoto Miyazaki (316683), Evgenia Dobrinskikh (252465), James Dylewski (6407510)   +6 more
core   +1 more source

Myeloid-Derived Suppressor Cells Induce Podocyte Injury Through Increasing Reactive Oxygen Species in Lupus Nephritis

Frontiers in Immunology, 2018
The expansion of myeloid-derived suppressor cells (MDSCs) has been documented in murine models and patients with lupus nephritis (LN), but the exact role of MDSCs in this process remains largely unknown.
Dongya Zhang, Jingjing Xu, Jing Ren, Liang Ding, Guoping Shi, Dan Li, Huan Dou, Huan Dou, Yayi Hou, Yayi Hou   +9 more
doaj   +1 more source