Results 91 to 100 of about 29,045 (218)

T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation

Advanced Science
T‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Tushuai Li, Wenxue Sun, Shenglong Zhu, Chengsheng He, Tong Chang, Jie Zhang, Yongquan Chen   +6 more
doaj   +1 more source

Attenuation of NADPH Oxidase Activation and Glomerular Filtration Barrier Remodeling With Statin Treatment [PDF]

, 2008
Activation of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase by angiotensin II is integral to the formation of oxidative stress in the vasculature and the kidney.
Andresen, Bradley T., Cooper, Shawna A., DeMarco, Vincent G., Ferrario, Carlos M., Habibi, Javad, 1947-, Hayden, Melvin, Karuparthi, Poorna R., Nistala, Ravi, Sowers, James R. (James Russell), 1942-, Wei, Yongzhong, Whaley-Connell, Adam T.   +10 more
core   +1 more source

Preventive Effect of Mineralocorticoid Receptor Antagonists Against Proteinuria Induced by Atezolizumab Plus Bevacizumab Therapy in Hepatocellular Carcinoma: A Multicenter Retrospective Study

Hepatology Research, EarlyView.
Mineralocorticoid receptor antagonists are known to reduce proteinuria in chronic kidney disease, but their effectiveness in preventing bevacizumab‐related proteinuria has not been well established. In the present multi‐institutional retrospective study, we found that these agents significantly delay the onset of moderate or higher grade proteinuria ...
Tomoki Hori, Kazuhiro Yamamoto, Hiroshi Aoi, Yusuke Koizumi, Makoto Kuromatsu, Aiko Fukui, Hiroyo Okamoto, Atsushi Hirata, Kentaro Shinmori, Yuki Imanaka, Miyu Namba, Keisuke Nakanishi, Syunsuke Kitamura, Hideo Tsushima, Ikuko Yano, Kei Moriya, Masaru Matsui, Shigeki Ikushima   +17 more
wiley   +1 more source

Chemical composition, antioxidant and alpha-Glucosidase-Inhibiting activities of the aqueous and hydroethanolic extracts of Vaccinium myrtillus Leaves [PDF]

, 2017
Vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern Europe for the treatment of diabetes. In the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration ...
Bljajic, Kristina, Cacic, Ana, de Carvalho, Isabel Saraiva, Jablan, Jasna, Koncic, Marijana Zovko, Petlevski, Roberta, Sostaric, Nina, Vujic, Lovorka   +7 more
core   +1 more source

Association of glucagon‐like peptide‐1 receptor agonist use with clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu, Ying Chun Lee, Yu‐Wei Fang, Wen‐Hui Hsieh, Ming‐Hsien Tsai   +4 more
wiley   +1 more source

Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]

, 2018
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Asfahani, R, Bellerby, J, Hohenstein, P, Miller-Hodges, EV, Moulding, D, Sampson, RD, Scambler, PJ, Sebire, NJ, Tahoun, MM, Virasami, AK, Waters, AM   +10 more
core  

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +4 more sources

Risk of end‐stage renal disease in Korean patients with type 2 diabetes according to cumulative low‐density lipoprotein cholesterol levels

Journal of Diabetes Investigation, EarlyView.
High cumulative LDL‐C levels increase ESRD risk in type 2 diabetes, particularly among patients using insulin, those receiving multiple antidiabetic medications, and those with longer diabetes duration. Longer exposure to elevated LDL‐C further increases risk, underscoring the need for intensive LDL‐C control.
Da‐Yeon Lee, Kyung‐Do Han, Ji‐Hee Ko, Han‐Na Jang, Sun Joon Moon, Hye‐Mi Kwon, Se‐Eun Park, Won‐Young Lee, Eun‐Jung Rhee   +8 more
wiley   +1 more source

Mesenchymal Stem Cell Therapy in Type 1 Diabetes Mellitus and Its Main Complications: From Experimental Findings to Clinical Practice [PDF]

, 2014
Type 1 diabetes mellitus (T1DM) is a complex multifactorial disorder which involves a loss of self-tolerance leading to the autoimmune destruction of pancreatic β−cells.
Arango Rodriguez, Martha, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core   +1 more source

The Complement System in Post‐Transplant Kidney Injury

Organ Medicine, EarlyView.
Mengsi Hu
wiley   +1 more source