Results 41 to 50 of about 899,728 (258)

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

Scientific Reports, 2022
Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease ...
William J. Mason, Daniyal J. Jafree, Gideon Pomeranz, Maria Kolatsi-Joannou, Antje K. Rottner, Sabrina Pacheco, Dale A. Moulding, Anja Wolf, Christian Kupatt, Claire Peppiatt-Wildman, Eugenia Papakrivopoulou, Paul R. Riley, David A. Long, Elisavet Vasilopoulou   +13 more
doaj   +1 more source

SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation

Kidney Diseases, 2021
Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang, Min Zhao, Mi Bai, Juan Lei, Yanggang Yuan, Songming Huang, Yue Zhang, Guixia Ding, Zhanjun Jia, Aihua Zhang   +9 more
doaj   +1 more source

SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway

Redox Biology, 2022
High fructose consumption is a significant risking factor for glomerular podocyte injury. However, the causes of high fructose-induced glomerular podocyte injury are still unclear.
Wen-Yuan Wu, Zi-Xuan Wang, Tu-Shuai Li, Xiao-Qin Ding, Zhi-Hong Liu, Jie Yang, Lei Fang, Ling-Dong Kong   +7 more
doaj   +1 more source

Podocyte injury and repair mechanisms

Current Opinion in Nephrology and Hypertension, 2015
Podocytes are the main gatekeeper of protein filtration in the glomerulus. When podocytes work less efficiently, this translates to the appearance of proteins in the urine, a condition that, if not promptly treated, leads to progression of glomerular damage and renal failure.Novel gene mutations have been uncovered in patients with nephrotic syndrome ...
CELLESI, FRANCESCO, Min Li, Maria Pia Rastaldi   +2 more
openaire   +3 more sources

Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/β-catenin signaling [PDF]

PeerJ, 2019
Background Diabetic nephropathy (DN) is one of the principal complications of diabetes and podocyte injury plays an important role in the DN pathogenesis. Wnt/β-catenin signaling overactivation confers podocyte injury and promotes multiple types of renal
Xiajing Che, Xin Deng, Kewei Xie, Qin Wang, Jiayi Yan, Xinghua Shao, Zhaohui Ni, Liang Ying   +7 more
doaj   +2 more sources

The MIF Receptor CD74 in Diabetic Podocyte Injury [PDF]

Journal of the American Society of Nephrology, 2009
Although metabolic derangement plays a central role in diabetic nephropathy, a better understanding of secondary mediators of injury may lead to new therapeutic strategies. Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74,
Sanchez-Nino, MD, Sanz, AB, Ihalmo, P, Lassila, M, Holthofer, H, Mezzano, S, Aros, C, Groop, PH, Saleem, MA, Mathieson, PW, Langham, R, Kretzler, M, Nair, V, Lemley, KV, Nelson, RG, Mervaala, E, Mattinzoli, D, Rastaldi, MP, Ruiz-Ortega, M, Martin-Ventura, JL, Egido, J, Ortiz, A   +21 more
openaire   +6 more sources

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]

, 2009
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Amann, Kerstin Ute, El Sayed, El Sayed M., Doberstein, Kai, Kämpfer-Kolb, Nicole, Abdel-Aziz, Abdel-Aziz H., Schäfer, Liliana, Gutwein, Paul, Pfeilschifter, Josef, Abdel-Bakky, Mohamed Sadek, Beckmann, Janet, Doller, Anke, Schramme, Anja   +11 more
core   +1 more source

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

Mediators of Inflammation, 2019
Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury.
Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng   +5 more
doaj   +1 more source

Research advances on the role of ubiquitin proteasome in podocyte injury of diabetic kidney disease

Linchuang shenzangbing zazhi
Diabetic kidney disease (DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis.
Jin Wang, Wen-ling Dai, Ji-hua Liu
doaj   +1 more source

Erk5 Mediates TGFβ1-induced Loss of Phenotype and Function in Human Podocytes [PDF]

, 2014
Diabetic nephropathy is one of the most common causes of renal impairment. Podocytes are specialised cells integral to normal kidney physiology, however in diabetes injury occurs leading to compromised function which is a critical factor in the ...
Irbaz I. Badshah, Irbaz Isaac Badshah, Deborah L. Baines, Dockrell, ME, Baines, DL, Mark Edward Dockrell, Mark E. Dockrell, Deborah L Baines, Badshah, II   +8 more
core   +1 more source