Results 21 to 30 of about 19,393 (195)
Podocyte Injury in Lupus Nephritis [PDF]
Journal of Clinical Medicine, 2019 Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in the glomeruli.
Sakhi, Hamza +7 more
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tRF-003634 alleviates adriamycin-induced podocyte injury by reducing the stability of TLR4 mRNA.
PLoS ONE, 2023 Podocyte injury plays a key role in the production of proteinuria and is closely related to the progression of chronic kidney disease (CKD). Alleviating podocyte injury is beneficial to prevent the occurrence and development of CKD.
Xiaoqing Gao +7 more
doaj +1 more source
Podocyte Biology and Response to Injury [PDF]
Journal of the American Society of Nephrology, 2002 The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms the final barrier to protein loss, which explains why podocyte injury is typically associated with ...
Peter, Mundel, Stuart J, Shankland
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Cells, 2021 Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway.
Xiaoying Gu, Su Zhang, Ti Zhang
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Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
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Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
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Role of Podocyte Injury in Glomerulosclerosis [PDF]
, 2019 Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to a living environment of various stresses and pathological stimuli, podocytes are prone to injuries; moreover, as a cell without proliferative potential, loss of podocytes is vital in the pathogenesis of glomerulosclerosis.
Lu, Chen-Chen +6 more
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Cytokines and podocyte injury: the mechanism of fibroblast growth factor 2-induced podocyte injury [PDF]
Nephrology Dialysis Transplantation, 1999 Our study is designed to find what promotes the of adhesive lesions due to proliferation of epithelial proliferation of epithelial cells in Bowman’s capsule. cells of Bowman’s capsule, since FGF2 administration It has been reported recently that fibroblast growth caused an increase in PCNA-positive epithelial cells of factor 2 ( FGF2) has a ...
T, Sasaki, H, Hatta, G, Osawa
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Effects of Podocyte Injury on Glomerular Development [PDF]
Pediatric Research, 2007 To study the effects of podocyte injury on glomerular maturation and underlying mechanisms of such effects, puromycin aminonucleoside (PAN) was given to neonatal mice at 1 d post partum (1 dpp). Mice with PAN injection had smaller kidney weight (KW) and body weight (BW) at all times and smaller KW/BW at 4, 8, and 12 dpp versus normal saline (NS ...
Ji, Ma +5 more
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Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury. [PDF]
PLoS ONE, 2013 The podocyte functions as a glomerular filtration barrier. Autophagy of postmitotic cells is an important protective mechanism that is essential for maintaining the homeostasis of podocytes. Exploring an in vivo rat model of passive Heymann nephritis and
Lingling Wu +10 more
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