SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway
Redox Biology, 2022 High fructose consumption is a significant risking factor for glomerular podocyte injury. However, the causes of high fructose-induced glomerular podocyte injury are still unclear.
Wen-Yuan Wu +7 more
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Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
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Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core +1 more source
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]
, 2020 Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D. +9 more
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Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury. [PDF]
PLoS ONE, 2013 The podocyte functions as a glomerular filtration barrier. Autophagy of postmitotic cells is an important protective mechanism that is essential for maintaining the homeostasis of podocytes. Exploring an in vivo rat model of passive Heymann nephritis and
Lingling Wu +10 more
doaj +1 more source
Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]
, 2019 The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe +1 more
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MicroRNAs in Podocyte Injury in Diabetic Nephropathy
Frontiers in Genetics, 2020 Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii +7 more
doaj +1 more source
Kidney Diseases, 2021 Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang +9 more
doaj +1 more source
Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice
Scientific Reports, 2022 Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease ...
William J. Mason +13 more
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