Results 11 to 20 of about 19,393 (195)

MicroRNAs in Podocyte Injury in Diabetic Nephropathy [PDF]

Frontiers in Genetics, 2020
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii, Shohei Kaneko, Katsunori Yanai, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +7 more
doaj   +5 more sources

Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

Frontiers in Pharmacology, 2021
Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Tongtong Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Yongli Zhan   +5 more
doaj   +3 more sources

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +3 more sources

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease [PDF]

Cell Death Discovery
Exosomes are extracellular vesicles involved in mediating cell–cell communication by shuttling genetic information and proteins. Here, we investigated whether glomerular endothelial cells-derived exosomes play a central role in mediating podocyte injury ...
Yuexin Tian, Yunhe Liu, Xiaojuan Feng, Lunbi Wu, Weiwei Song, Tongyu Zhao, Jinxi Liu, Xinyan Miao, Haimin Ma, Baiyun Jia, Lihua Kang, Qingjuan Liu, Wei Zhang, Huifang Guo, Lin Yang, Jinsheng Xu, Shuxia Liu   +16 more
doaj   +2 more sources

SPARC upregulation mediates podocyte injury in Alport syndrome mice [PDF]

BMC Nephrology
Background Alport syndrome (AS) is a hereditary kidney disease characterized by hematuria, proteinuria, and progressive kidney failure. Podocyte injury is an important feature of AS, but the underlying molecular mechanisms remain incompletely understood.
Dongxuan Chi, Hongyuan Chu, Jing Nie, Yanqin Zhang, Fang Wang, Jie Ding   +5 more
doaj   +2 more sources

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy [PDF]

PeerJ, 2023
Podocyte injury is a critical factor in the pathogenesis of diabeticnephropathy (DN). Emerging evidence has demonstrated that breviscapine (Bre) exerts a renoprotective effect on diabetic rats.
Linlin Sun, Miao Ding, Fuhua Chen, Dingyu Zhu, Xinmiao Xie   +4 more
doaj   +2 more sources

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

Cell Death and Disease, 2022
A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent podocyte injury is important from a clinical perspective in the treatment of LN.
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi   +9 more
doaj   +1 more source

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang, Jiafeng Liu, Xiaoyao Zhang, Qiyan Chen, Xiaoyan Bai, Xue Hong, Lili Zhou, Youhua Liu, Youhua Liu   +8 more
doaj   +1 more source

Podocyte Injury Damages Other Podocytes [PDF]

Journal of the American Society of Nephrology, 2011
Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka, Eric, Sandgren, Ayumi, Shintani, Valentina, Kon, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +6 more
openaire   +2 more sources

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes ...
Tianwen Yao, Wenxiang Su, Shisheng Han, Yan Lu, Yanqiu Xu, Min Chen, Yi Wang   +6 more
doaj   +1 more source