Results 11 to 20 of about 899,728 (258)

Urinary biomarkers associated with podocyte injury in lupus nephritis [PDF]

Frontiers in Pharmacology
The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular ...
Zhiying Guo, Qianyu Guo, Xiaochen Li, Xinnan Gao, Liyun Zhang, Ke Xu   +5 more
doaj   +4 more sources

Podocyte Injury in Lupus Nephritis [PDF]

Journal of Clinical Medicine, 2019
Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in the glomeruli.
Sakhi, Hamza, Moktefi, Anissa, Bouachi, Khedidja, Audard, Vincent, Hénique, Carole, Remy, Philippe, Ollero, Mario, El Karoui, Khalil   +7 more
openaire   +4 more sources

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.

PLoS ONE, 2014
Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada, Jin Nakamura, Misako Asada, Masayuki Takase, Taiji Matsusaka, Taku Iguchi, Ryo Yamada, Mari Tanaka, Atsuko Y Higashi, Tomohiko Okuda, Nariaki Asada, Atsushi Fukatsu, Hiroshi Kawachi, Daniel Graf, Eri Muso, Toru Kita, Takeshi Kimura, Ira Pastan, Aris N Economides, Motoko Yanagita   +19 more
doaj   +2 more sources

Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. [PDF]

PLoS ONE, 2015
Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable.
Jian-Si Li, Xiao Chen, Lei Peng, Shi-Yao Wei, Shi-Lei Zhao, Tian-Tian Diao, Yi-Xin He, Fang Liu, Qiu-Ju Wei, Qing-Fang Zhang, Bing Li   +10 more
doaj   +2 more sources

Effects of Podocyte Injury on Glomerular Development [PDF]

Pediatric Research, 2007
To study the effects of podocyte injury on glomerular maturation and underlying mechanisms of such effects, puromycin aminonucleoside (PAN) was given to neonatal mice at 1 d post partum (1 dpp). Mice with PAN injection had smaller kidney weight (KW) and body weight (BW) at all times and smaller KW/BW at 4, 8, and 12 dpp versus normal saline (NS ...
Ji, Ma, Michele, Rossini, Hai-Chun, Yang, Yiqin, Zuo, Agnes B, Fogo, Iekuni, Ichikawa   +5 more
openaire   +3 more sources

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +2 more sources

Mosaicism of Podocyte Involvement Is Related to Podocyte Injury in Females with Fabry Disease [PDF]

PLoS ONE, 2014
Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, occurs in ∼ 15% of females. Recent studies highlight the importance of podocyte injury in Fabry nephropathy development and progression.
Mauer, Michael, Glynn, Emily, Svarstad, Einar, Tøndel, Camilla, Gubler, Marie-Claire, West, Michael, Sokolovskiy, Alexey, Whitley, Chester, Najafian, Behzad   +8 more
openaire   +8 more sources

SPARC upregulation mediates podocyte injury in Alport syndrome mice [PDF]

BMC Nephrology
Background Alport syndrome (AS) is a hereditary kidney disease characterized by hematuria, proteinuria, and progressive kidney failure. Podocyte injury is an important feature of AS, but the underlying molecular mechanisms remain incompletely understood.
Dongxuan Chi, Hongyuan Chu, Jing Nie, Yanqin Zhang, Fang Wang, Jie Ding   +5 more
doaj   +2 more sources

Podocyte injury in diabetes mellitus [PDF]

Diabetes mellitus, 2014
The mechanisms of podocyte injury and their correlation with metabolic and haemodynamic disorders in diabetes mellitus are considered in detail; the results of the last experimental and clinical studies on this problem are presented in this review. Authors shined the biomarkers, reflecting expressiveness of podocytopathy and structural and functional ...
Irina Nikolaevna Bobkova, Marina Vladimirovna Shestakova, Anna Alexandrovna Shchukina   +2 more
openaire   +3 more sources

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy [PDF]

PeerJ, 2023
Podocyte injury is a critical factor in the pathogenesis of diabeticnephropathy (DN). Emerging evidence has demonstrated that breviscapine (Bre) exerts a renoprotective effect on diabetic rats.
Linlin Sun, Miao Ding, Fuhua Chen, Dingyu Zhu, Xinmiao Xie   +4 more
doaj   +2 more sources