Results 41 to 50 of about 3,511 (163)

Podocalyxin enhances the adherence of cells to platelets

Cellular and Molecular Life Sciences, 2007
Podocalyxin (PODXL) is a mucin protein of the CD34 family expressed in kidney glomerular podocytes, vascular endothelium, progenitor bone marrow and tumor cells. It is assumed that PODXL plays an anti-adherent role in kidney podocytes. CHO cells stably expressing human PODXL (CHO-PODXL) or human tumor cells (Tera-1) inherently expressing PODXL showed ...
Larrucea, Susana, Butta, Nora, Rodríguez, Ramón B., Alonso, Sonia, García Arias-Salgado, Elena, Sánchez Ayuso, Matilde, Parrilla, Roberto L.   +6 more
openaire   +3 more sources

Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro

Pharmaceutics, 2020
Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as promising candidates for receptor-mediated transcytosis across the blood–brain barrier (BBB).
Shingo Ito, Mariko Oishi, Seiryo Ogata, Tatsuki Uemura, Pierre-Olivier Couraud, Takeshi Masuda, Sumio Ohtsuki   +6 more
doaj   +1 more source

Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant

Molecular Genetics & Genomic Medicine, 2021
Background Podocalyxin (PODXL) is a highly sialylated adhesion glycoprotein that plays an important role in podocyte's physiology. Recently, missense and nonsense dominant variants in the PODXL gene have been associated with focal segmental ...
David Marx, Sophie Caillard, Jérôme Olagne, Bruno Moulin, Thierry Hannedouche, Guy Touchard, Arnaud Dupuis, Christian Gachet, Anne Molitor, Seiamak Bahram, Raphael Carapito   +10 more
doaj   +1 more source

The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.

PLoS ONE, 2007
BackgroundPodocalyxin is a CD34-related transmembrane protein involved in hematopoietic cell homing, kidney morphogenesis, breast cancer progression, and epithelial cell polarization.
Julie S Nielsen, Marcia L Graves, Shierley Chelliah, A Wayne Vogl, Calvin D Roskelley, Kelly M McNagny   +5 more
doaj   +1 more source

Urinary Podocalyxin as a Biomarker to Diagnose Membranous Nephropathy

PLOS ONE, 2016
A non-invasive diagnostic marker of membranous nephropathy (MN) is desirable. The urinary level of podocalyxin (PCX) is higher in various glomerular diseases, including MN. The aim of this study was to construct a diagnostic model of MN with the combination of urinary PCX and clinical parameters.We performed this cross-sectional study to construct the ...
Takahiro Imaizumi, Masahiro Nakatochi, Shin’ichi Akiyama, Makoto Yamaguchi, Hiroyuki Kurosawa, Yoshiaki Hirayama, Takayuki Katsuno, Naotake Tsuboi, Masanori Hara, Shoichi Maruyama   +9 more
openaire   +4 more sources

Markers of kidney injury, lipid metabolism, and carbonyl stress in patients with type 1 diabetes and different levels of albuminuria

Бюллетень сибирской медицины, 2022
The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods.
M. A. Darenskaya, E. V. Chugunova, S. I. Kolesnikov, L. A. Grebenkina, N. V. Semyonova, O. A. Nikitina, L. I. Kolesnikova   +6 more
doaj   +1 more source

Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia

Brazilian Journal of Nephrology, 2018
Introduction: preeclampsia can be associated with future renal disease. Objectives: To measure changes in renal function overtime in patients with preeclampsia.
Ylbe Palacios de Franco, Karina Velazquez, Natalia Segovia, Gladys Sandoval, Estefania Gauto, Ylbe V. Franco Palacios, Carlos R Franco Palacios   +6 more
doaj   +1 more source

Podocalyxin variants and risk of prostate cancer and tumor aggressiveness [PDF]

Human Molecular Genetics, 2006
We previously reported linkage of a prostate cancer tumor aggressiveness locus to chromosome 7q32-q33, a region also associated with a high frequency of allelic imbalance in prostate tumors. The smallest region of allelic imbalance contains the podocalyxin-like (PODXL) gene, which we evaluate here as a candidate prostate cancer aggressiveness gene ...
Graham, Casey, Phillippa J, Neville, Xin, Liu, Sarah J, Plummer, Mine S, Cicek, Lisa M, Krumroy, Anthony P, Curran, Michelle R, McGreevy, William J, Catalona, Eric A, Klein, John S, Witte   +10 more
openaire   +2 more sources

Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site

Frontiers in Immunology, 2022
Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction.
Laura Amo, Javier Díez-García, Estíbaliz Tamayo-Orbegozo, Natalia Maruri, Susana Larrucea   +4 more
doaj   +1 more source

Role of podocalyxin in astrocytoma: Clinicopathological and in vitro evidence

Oncology Letters, 2013
The present study examined the expression of podocalyxin (PODX) in surgically-resected astrocytomas, associated the levels of PODX expression with the clinicopathological characteristics and survival outcomes of astrocytoma and assessed how PODX affected the viability of astrocytoma cells following the administration of chemotherapeutic agents.
HUANG, TIANXIANG, JIN, XIN, HE, LEI, ZHANG, MINGYU, WU, JUN, WANG, YANJIN, FANG, JIASHENG   +6 more
openaire   +3 more sources