Results 11 to 20 of about 3,511 (163)

Role of urinary podocalyxin in early diagnosis of diabetic nephropathy [PDF]

Romanian Journal of Internal Medicine, 2020
Introduction. Podocyte injury has been reported as an early feature of DN therefore, the assessment of podocyte injury can be accomplished by estimation of podocalyxin in urine. This study aimed to estimate the urinary podocalyxin levels and to determine
Kostovska Irena, Trajkovska Katerina Tosheska, Cekovska Svetlana, Topuzovska Sonja, Kavrakova Julijana Brezovska, Spasovski Goce, Kostovski Ognen, Labudovic Danica   +7 more
doaj   +3 more sources

Protective Effects of Physalis angulata on Podocythopathies Through B-Cell-Activating Factor Inhibition in Doxorubicin-Induced Nephrotic Syndrome Rat Model [PDF]

Biomedicines
Background/Objectives: Nephrotic syndrome, a glomerular disease caused by podocyte dysfunction, is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Astrid K. Kardani, Loeki E. Fitri, Nur Samsu, Krisni Subandiyah   +3 more
doaj   +2 more sources

Podocalyxin, Isthmin-1, and Pentraxin-3 Immunoreactivities as Emerging Immunohistochemical Markers of Fibrosis in Chronic Hepatitis B [PDF]

Biomedicines
Introduction and Objectives: Persistent hepatic inflammation serves as a key driver of fibrogenesis in chronic hepatitis B. Fibrosis is a complex molecular and cellular process.
Müge Özgüler, Serhat Hançer, Özgen Arslan Solmaz, Tuncay Kuloğlu   +3 more
doaj   +2 more sources

The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes [PDF]

BMC Nephrology
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) have pleiotropic properties that may affect glomerular podocytes.
Chuanlei Li, Jack K. C. Ng, Gordon C. K. Chan, Winston W. S. Fung, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +2 more sources

A Cancer-Specific Anti-Podocalyxin Monoclonal Antibody (humPcMab-60) Demonstrated Antitumor Efficacy in Pancreatic and Colorectal Cancer Xenograft Models [PDF]

Antibodies
Background: Podocalyxin (PODXL) has been identified as a promising therapeutic target and a potential diagnostic biomarker in various tumors. Despite the therapeutic potential of anti-PODXL monoclonal antibodies (mAbs), their further development has been
Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato   +7 more
doaj   +2 more sources

Podocyte‐Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease [PDF]

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu, Xi Liu, Xin Wen, Siyu Yan, Meizhi He, Jie Xu, Zhanji Zhan, Haili Zhu, Huishi Tan, Nan Jia, Youhua Liu   +10 more
wiley   +2 more sources

Assessment of urinary podocalyxin as a biomarker of early diagnosis of hypertensive nephropathy [PDF]

The Ukrainian Biochemical Journal, 2023
Chronically high blood pressure-related kidney injury is known as hypertensive nephropathy (HN). Podocyte damage in the pathogenesis of this disease can result in the release of the sialoglycoprotein podocalyxin into the urine, so podocalyxin may be ...
I. Kostovska, K. Tosheska-Trajkovska, D. Labudovic, S. Cekovska, O. Kostovski, G. Spasovski   +5 more
doaj   +1 more source

Anti-Adhesive Podocalyxin Expression Is Disrupted in Recurrent Implantation Failure

Diagnostics
Objectives: The downregulation of anti-adhesive regulatory proteins and upregulation of adhesive genes are critical for the receptive endometrium. This study was designed to determine whether switching between the anti-adhesive podocalyxin (PDX) and ...
Mustafa Tas
doaj   +3 more sources

Podocalyxin in Normal Tissue and Epithelial Cancer [PDF]

Cancers, 2021
Podocalyxin (PODXL), a glycosylated cell surface sialomucin of the CD34 family, is normally expressed in kidney podocytes, vascular endothelial cells, hematopoietic progenitors, mesothelium, as well as a subset of neurons. In the kidney, PODXL functions primarily as an antiadhesive molecule in podocyte epithelial cells, regulating adhesion and cell ...
Ngoc Le Tran, Yao Wang, Guiying Nie
openaire   +2 more sources

Preservation of Urinary Podocyte Markers in Diabetic Kidney Disease by Sodium-Glucose Cotransporter 2 Inhibitor Therapy [PDF]

Kidney Diseases
Introduction: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a standard treatment for kidney and cardiovascular protection in diabetic kidney disease (DKD). We investigated the effect of SGLT2i on the urinary podocyte-associated molecule
Chuanlei Li, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +2 more sources