Results 11 to 20 of about 8,883 (209)

Urinary Nephrin as an Early Biomarker of Hypertensive Nephropathy

Acta Clinica Croatica, 2023
Hypertensive nephropathy (HN) is characterized by kidney damage due to chronic high blood pressure. Podocytes play a crucial role in the pathogenesis of HN, thus, nephrin could be important in the early diagnosis of HN.
Irena Kostovska, Katerina Tosheska Trajkovska, Danica Labudović, Ognen Kostovski, Goce Spasovski   +4 more
doaj   +3 more sources

Nephrin in experimental glomerular disease [PDF]

Kidney International, 2000
The recently identified gene NPHS1 with its mutations causing congenital nephrotic syndrome of the Finnish type (CNF) is highly promising in providing new understanding of pathophysiology of proteinuria. Earlier we cloned a rat NPHS1 homologue, as well as characterized and raised antibodies to the respective protein product nephrin.Changes in the ...
Luimula, Pauliina, Ahola, Heikki, Wang, Shi-Xuan, Solin, Marja-Liisa, Aaltonen, Petri, Tikkanen, Ilkka, Kerjaschki, Dontscho, Holthöfer, Harry   +7 more
openaire   +3 more sources

Autoantibodies against nephrin and podocin are associated with disease severity and steroid dependence in adult-onset nephrotic syndrome [PDF]

Scientific Reports
Nephrotic syndrome is a glomerular disorder characterized by heavy proteinuria and hypoalbuminemia. Autoantibodies against slit diaphragm proteins such as nephrin and podocin have been identified in subsets of patients, but their prevalence and clinical ...
Norifumi Hayashi, Ryoko Akai, Yu Kagaya, Keiji Fujimoto, Takao Iwawaki, Hitoshi Yokoyama, Kengo Furuichi   +6 more
doaj   +2 more sources

Urinary Excretion of Nephrin in Patients with Severe Preeclampsia

Hypertension in Pregnancy, 2010
The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia.A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group.
Ga Hyun, Son, Jeong Hyeon, Kim, Jung Hae, Hwang, Young Han, Kim, Yong Won, Park, Ja Young, Kwon   +5 more
openaire   +4 more sources

Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin [PDF]

Biochemical Journal, 2011
Slit diaphragms are specialized junctions between glomerular epithelial cells (podocytes) that are crucial for glomerular ultrafiltration. The Ig superfamily members nephrin and Neph1 are essential components of the slit diaphragm, whereas the role of Neph1 homologue Neph3 in the slit diaphragm is unknown.
Heikkilä Eija Kaarina, Holthofer Harry, Havana Marika, Ristola Mervi, Lehtonen Sanna, Heikkilä Eija Kaarina, Holthofer Harry, Havana Marika, Ristola Mervi, Lehtonen Sanna   +9 more
openaire   +4 more sources

Anion Exchanger 1 Interacts with Nephrin in Podocytes [PDF]

Journal of the American Society of Nephrology, 2010
The central role of the multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaphragm is well established, but the mechanisms linking the slit diaphragm to the cytoskeleton and to the signaling pathways involved in maintaining the integrity of the glomerular filter remain incompletely understood.
Wu, F, Saleem, M.A, Kampik, N.B, Satchwell, T.J, Williamson, R.C, Blattner, S.M, Ni, L, Toth, T, White, G, Young, M.T, Parker, M.D, Alper, S.L, Wagner, C.A, Toye, A.M   +13 more
openaire   +5 more sources

Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study [PDF]

Frontiers in Nephrology
IntroductionPodocyte injury plays a central role in the development of diabetic kidney disease (DKD). Urinary podocin, nephrin, and the podocin–nephrin ratio (PNR) have been proposed as early indicators of glomerular injury, but their prognostic value ...
Pringgodigdo Nugroho, Jeremia Siregar, Jeremia Siregar, Tri Juli Edi Tarigan, Kuntjoro Harimurti, Aida Lydia, Evy Yunihastuti, Pradana Soewondo, Hamzah Shatri   +8 more
doaj   +2 more sources

Heparanase inhibition prevents glycocalyx damage and albuminuria in experimental minimal change disease. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Crompton M, Ramnath RD, Betteridge K, Desideri S, Alonso AM, Jiang L, Gamez M, Stowell-Connolly H, Vasylchenko V, Onions KL, Butler MJ, Neal CR, Salmon AHJ, Turnbull JE, Kawachi H, Zubkova OV, Welsh GI, Satchell SC, Foster RR.   +18 more
europepmc   +2 more sources

Podocyte Markers as Diagnostic Biomarkers of Diabetic Nephropathy: A Case-Control Comparison to Haemato-Biochemical Markers in a Ghanaian Population. [PDF]

Endocrinol Diabetes Metab
This study shows that urinary nephrin and related podocyte injury markers are elevated among people living with diabetes in Ghana, particularly those with macroalbuminuria. Nephrin demonstrated discriminatory ability, supporting its role as an exploratory biomarker for diabetic nephropathy rather than a standalone diagnostic tool.
Owusu-Asante H, Darko SN, Senu E, Annani-Akollor M.   +3 more
europepmc   +2 more sources

Serum and Glucocorticoid-Inducible Kinase 3/Nedd4-2 Signaling Pathway Participates in Podocyte Injury by Regulating the Stability of Nephrin

Frontiers in Physiology, 2022
Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein.
Qing-Qing Dong, Zi-Fang Li, Zi-Fang Li, Hui Zhang, Hua-Pan Shu, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Yao   +7 more
doaj   +1 more source