Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes [PDF]
Cell & Bioscience, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Luyao Wang +4 more
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A novel in vivo method to quantify slit diaphragm protein abundance in murine proteinuric kidney disease. [PDF]
PLoS ONE, 2017 Injury of the glomerular filter causes proteinuria by disrupting the sensitive interplay of the glomerular protein network. To date, studies of the expression and trafficking of glomerular proteins have been mostly limited to in vitro or histologic ...
Raphael Haase +11 more
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Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach [PDF]
Frontiers in Medicine, 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu +4 more
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Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes. [PDF]
J Am Soc NephrolKey Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in ...
Leroy C +9 more
europepmc +4 more sources
Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila. [PDF]
J Am Soc NephrolKey Points Piezo channels, known for detecting mechanical pressure, were found to be expressed at the lacuna channel membranes of nephrocytes.Piezo loss of function caused nephrocyte dysfunction, including disrupted slit diaphragm structure and altered lacuna channel morphology.Piezo deficiency
Zhao Y +5 more
europepmc +3 more sources
The kidney slit diaphragm resembles a fishnet
Kidney InternationalAn essential component of the kidney filtration barrier, the slit diaphragm, is a specialized cell-cell junction composed of the cell adhesion molecules Nephrin and Neph1.Here, we use cryo-electron tomography of vitreous lamellae from high pressure frozen wild-type C57BL/6J native mouse glomeruli.The cryo-electron tomograms show that the slit diaphragm
Sina Manger, Margot P Scheffer
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Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex. [PDF]
J Am Soc Nephrol, 2019 Significance StatementThe connection between the slit diaphragm and actin network of podocytic foot processes involves complex signaling between slit diaphragm proteins and multiple signaling pathways of the actin machinery. CD2AP, a slit diaphragm–associated scaffolding protein, is considered a “stabilizer” of the complex that connects the slit ...
Tossidou I +15 more
europepmc +4 more sources
Hypoxia decreases podocyte expression of slit diaphragm proteins
International Journal of Nephrology and Renovascular Disease, 2012 Hong Lu,1 Gaurav Kapur,1 Tej K Mattoo,1 William D Lyman1,21Carman and Ann Adams Department of Pediatrics, 2Children's Research Center of Michigan, Children's Hospital of Michigan, Detroit, MI, USABackground: Chronic hypoxia contributes to
Lu H, Kapur G, Mattoo TK, Lyman WD
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Mechanotransduction and the Integrity of the Slit Diaphragm. [PDF]
J Am Soc NephrolHill RZ.
europepmc +3 more sources
New insight into podocyte slit diaphragm, a therapeutic target of proteinuria [PDF]
Clinical and Experimental Nephrology, 2020 Hiroshi Kawachi +2 more
exaly +2 more sources