Results 41 to 50 of about 7,412 (180)
Taking a bite: endocytosis in the maintenance of the slit diaphragm [PDF]
Journal of Clinical Investigation, 2012 In the kidney, the slit diaphragm joins adjacent podocytes, forming an epithelial barrier that filters plasma into the urinary space, yet retains blood cells and proteins within the circulation. In this issue of the JCI, Soda et al. have identified clathrin-mediated endocytosis as a central mechanism by which the function and structural integrity of ...
Rosemary V, Sampogna, Qais, Al-Awqati
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Sensitizing the Slit Diaphragm with TRPC6 Ion Channels [PDF]
Journal of the American Society of Nephrology, 2009 Physiologic permeability of the glomerular capillary depends on the normal structure of podocyte foot processes forming a functioning slit diaphragm in between. Mutations in several podocyte genes as well as specific molecular pathways have been identified as the cause for progressive kidney failure with urinary protein loss.
Clemens C, Möller +2 more
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Frontiers in Cell and Developmental Biology, 2023 Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit ...
Gary F. Gerlach +4 more
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Renal Failure, 2023 Diabetic kidney disease (DKD) is a primary cause of end-stage renal disease. Proteinuria is a clinical indicator of the different stages of DKD, and podocyte injury is a major cause of proteinuria.
Le Gong +7 more
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Frontiers in Endocrinology, 2014 The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture.
Beina eTeng +4 more
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PLoS ONE, 2013 Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. Especially, the highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. This is highlighted by the
Zhijie Xiao +5 more
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Kif21a deficiency leads to impaired glomerular filtration barrier function
Scientific Reports, 2023 The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and a number of other functions such as metabolic waste elimination and the regulation of water, electrolyte and acid–base balance.
Hanna Riedmann +4 more
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Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte
Kidney International, 1996 Murine monoclonal antibody 5-1-6 was reported to bind to the slit membrane and closely related structures in rat renal glomeruli; it induced heavy, reversible proteinuria and appeared to redistribute onto the plasma membrane of epithelial cells after binding at the original target sites.
Fujigaki, Yoshihide +8 more
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Current concepts of the podocyte in nephrotic syndrome
Kidney Research and Clinical Practice, 2012 Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the filtration mechanism of the glomerular filtration barrier is the podocyte.
Wen Y. Ding, Moin A. Saleem
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Morphine induces albuminuria by compromising podocyte integrity.
PLoS ONE, 2013 Morphine has been reported to accelerate the progression of chronic kidney disease. However, whether morphine affects slit diaphragm (SD), the major constituent of glomerular filtration barrier, is still unclear.
Xiqian Lan +11 more
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