Results 61 to 70 of about 7,412 (180)
Advanced Science, EarlyView.Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler +4 more
wiley +1 more source
The isoporous substructure of the human glomerular slit diaphragm
Kidney International, 1975 The substructure of the human glomerular slit diaphragm is examined after perfusion fixation of a human kidney with tannic acid-glutaraldehyde. The present study shows that the substructure of the slit diaphragm in man is very similar to that described in rats and mice, and that the dimensions of the contained pores (50 times 120 A) in the human differ
Schneeberger, Eveline E. +3 more
openaire +2 more sources
New perspectives on the renal slit diaphragm protein podocin [PDF]
Modern Pathology, 2011 Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain ...
Relle, Manfred +6 more
openaire +2 more sources
Advanced Science, EarlyView.A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley +1 more source
Using the Drosophila Nephrocyte to Model Podocyte Function and Disease
Frontiers in Pediatrics, 2017 Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations ...
Martin Helmstädter +4 more
doaj +1 more source
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis. [PDF]
PLoS ONE, 2011 The assembly of specific synaptic connections represents a prime example of cellular recognition. Members of the Ig superfamily are among the most ancient proteins represented in the genomes of both mammalian and invertebrate organisms, where they ...
Nicola Wanner +5 more
doaj +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Existing soft pumps often require tradeoffs between performance and compatibility with soft robotic systems. The proposed trielectrode electrostatic soft pump addresses these limitations through an innovative driving mechanism. Its design, which includes a trielectrode configuration and the use of compliant materials, improves operational efficiency ...
Yangqiao Lin +10 more
wiley +1 more source
Scientific Reports, 2017 Helium ion scanning microscopy (HIM) is a novel technology that directly visualizes the cell surface ultrastructure without surface coating. Despite its very high resolution, it has not been applied extensively to study biological or pathology samples ...
Kenji Tsuji +6 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.HTFC gets 3D refractive index tomograms of flowing cells. Label‐free monocytes are engineered to express patterns of cytoplasmic vacuoles. From the tomogram, an efficient dimensionality reduction is operated. Interpretable features are extracted to classify the expression severity of phenotypes coexisting in each cell, visually represented by a seven ...
Marika Valentino +9 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source