Results 31 to 40 of about 7,412 (180)

From slit diaphragm to autoantigen formation: a SUMOylation-based perspective on minimal change disease [PDF]

Frontiers in Nephrology
Emre Leventoğlu, Bahar Büyükkaragöz, Sevcan A. Bakkaloğlu   +2 more
doaj   +2 more sources

In vivo characterization of a podocyte-expressed short podocin isoform

BMC Nephrology, 2023
The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a
Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne   +8 more
doaj   +1 more source

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. [PDF]

PLoS ONE, 2013
Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the ...
Markus Gödel, Benjamin N Ostendorf, Jessica Baumer, Katrin Weber, Tobias B Huber   +4 more
doaj   +1 more source

FAT is a component of glomerular slit diaphragms [PDF]

Kidney International, 2001
Slit diaphragms are intercellular junctions of podocytes of the renal glomerulus. The molecular composition of slit diaphragms is still elusive. Slit diaphragms are characterized by the presence of a wide intercellular space. The morphological feature is shared by desmosomes and adherens junctions, which contain members of the cadherin superfamily ...
Inoue, Tsutomu, Yaoita, Eishin, Kurihara, Hidetake, Shimizu, Fujio, Sakai, Tatsuo, Kobayashi, Tatsuya, Ohshiro, Kazufumi, Kawachi, Hiroshi, Okada, Hirokazu, Suzuki, Hiromichi, Kihara, Itaru, Yamamoto, Tadashi   +11 more
openaire   +2 more sources

Structural features and oligomeric nature of human podocin domain

Biochemistry and Biophysics Reports, 2020
Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity.
Sandeep K.N. Mulukala, Shivkumar S. Irukuvajjula, Krishan Kumar, Kanchan Garai, Pannuru Venkatesu, Ramakrishna Vadrevu, Anil K. Pasupulati   +6 more
doaj   +1 more source

The Glomerular Slit Diaphragm Is a Modified Adherens Junction [PDF]

Journal of the American Society of Nephrology, 2000
Abstract. The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction. Differentiated cultured podocytes form cellular structures comparable to filtration slits in vivo. At those sites, zonula occludens-1 (ZO-1) was coexpressed with P-cadherin as well as with α-, β-
Jochen, Reiser, Wilhelm, Kriz, Matthias, Kretzler, Peter, Mundel   +3 more
openaire   +2 more sources

Slit Diaphragms Contain Tight Junction Proteins [PDF]

Journal of the American Society of Nephrology, 2009
Slit diaphragms are essential components of the glomerular filtration apparatus, as changes in these junctions are the hallmark of proteinuric diseases. Slit diaphragms, considered specialized adherens junctions, contain both unique membrane proteins (e.g., nephrin, podocin, and Neph1) and typical adherens junction proteins (e.g., P-cadherin, FAT, and ...
Hirotaka, Fukasawa, Scott, Bornheimer, Krystyna, Kudlicka, Marilyn G, Farquhar   +3 more
openaire   +2 more sources

Podocin Localizes in the Kidney to the Slit Diaphragm Area [PDF]

The American Journal of Pathology, 2002
We recently cloned a novel gene, NPHS2, involved in autosomal recessive steroid-resistant nephrotic syndrome. This gene encodes a novel podocyte protein, podocin. Given its similarity with the stomatin family proteins, podocin is predicted to be an integral membrane protein with a single membrane domain forming a hairpin-like structure placing both N ...
Séverine, Roselli, Olivier, Gribouval, Nicolas, Boute, Mireille, Sich, France, Benessy, Tania, Attié, Marie-Claire, Gubler, Corinne, Antignac   +7 more
openaire   +2 more sources

Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. [PDF]

PLoS ONE, 2009
The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body.
Behnam Nabet, Arthur Tsai, John W Tobias, Russ P Carstens   +3 more
doaj   +1 more source

Signaling at the Slit Diaphragm [PDF]

Journal of the American Society of Nephrology, 2004
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure. Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the size-selective filtration barrier of the kidney and revealed novel aspects of the mechanisms that lead ...
openaire   +3 more sources