Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity [PDF]
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
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Oxidative Stress Contributes to Slit Diaphragm Defects Caused by Disruption of Endocytosis [PDF]
Kidney International ReportsIntroduction: Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered ...
Gang Xi, John S Poulton
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Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins. [PDF]
PLoS ONE, 2021 Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Sandeep K N Mulukala +3 more
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The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture [PDF]
Nature CommunicationsThe kidney relies on the glomerulus to filter large volumes of blood plasma, with the slit diaphragm (SD) as a key structural component of the glomerular filtration barrier.
Deborah Moser +7 more
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Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes [PDF]
Stem Cell Reports, 2018 Summary: Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes.
Shunsuke Tanigawa +2 more
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Endocytic Trafficking at the Mature Podocyte Slit Diaphragm [PDF]
Frontiers in Pediatrics, 2017 Endocytic trafficking couples cell signaling with the cytoskeletal dynamics by organizing a crosstalk between protein networks in different subcellular compartments. Proteins residing in the plasma membrane are internalized and transported as cargo in endocytic vesicles (i.e., endocytosis). Subsequently, cargo proteins can be delivered to lysosomes for
Agnieszka Swiatecka-Urban
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Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
eLife, 2022 The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
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mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Dominik Spitz +6 more
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A slit-diaphragm-associated protein network for dynamic control of renal filtration [PDF]
Nature Communications, 2022 The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads to ...
Maciej K. Kocylowski +21 more
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Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Megan Delaney +4 more
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