Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs [PDF]
Nature Communications, 2023 Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are ongoing.
Seong Kyu Han +15 more
doaj +2 more sources
Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Nephrocyte Injury and Proteinuria in a Diabetic Nephropathy Rat Model [PDF]
Journal of Diabetes Research, 2020 Mesenchymal stem cells (MSCs) are shown to alleviate renal injury of diabetic nephropathy (DN) in rats. However, the underlying mechanism of this beneficial effect is not fully understood.
Lian Chen +7 more
doaj +2 more sources
The Drosophila Nephrocyte - Modeling Podocyte Function and Disease [PDF]
, 2019 In den modernen Industrienationen haben sich chronische nichtübertragbare Krankheiten zur Hauptursache menschlicher Sterblichkeit entwickelt. Während der letzten Jahre wuchs die globale Belastung der Gesundheitssysteme durch chronische Nierenleiden beträchtlich und in vielen dieser Fälle sind weder gezielte noch personalisierte Therapien verfügbar.
Hochapfel, Florian
openaire +4 more sources
Modeling Podocyte Biology Using Drosophila Nephrocytes [PDF]
, 2019 Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and
Hartley, Paul S, Coward, Richard J
openaire +6 more sources
Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes [PDF]
Cellular and Molecular Life Sciences, 2017 Mammalian podocytes, the key determinants of the kidney's filtration barrier, differentiate from columnar epithelial cells and several key determinants of apical-basal polarity in the conventional epithelia have been shown to regulate podocyte morphogenesis and function.
Florian Hochapfel +10 more
openaire +3 more sources
ELifeChronic kidney disease is a major health issue and is gaining prevalence. Using a Drosophila model for chronic kidney disease, we show that a high-fat diet (HFD) disrupts the slit diaphragm filtration structure in nephrocytes, the fly functional ...
Yunpo Zhao +2 more
exaly +3 more sources
Diet-Induced Podocyte Dysfunction in Drosophila and Mammals [PDF]
Cell Reports, 2015 Diabetic nephropathy is a major cause of end-stage kidney disease. Characterized by progressive microvascular disease, most efforts have focused on injury to the glomerular endothelium.
Jianbo Na +4 more
doaj +3 more sources
Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy [PDF]
Disease Models & MechanismsJun-yi Zhu +2 more
doaj +2 more sources
Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes. [PDF]
Kidney Int Rep, 2023 Genetic disorders are among the most prevalent causes leading to progressive glomerular disease and, ultimately, end-stage renal disease (ESRD) in children and adolescents. Identification of underlying genetic causes is indispensable for targeted treatment strategies and counseling of affected patients and their families.Here, we report on a boy who ...
Odenthal J +19 more
europepmc +5 more sources
Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model. [PDF]
Pediatr Nephrol, 2022 BACKGROUND: Variants in genes encoding nuclear pore complex (NPC) proteins are a newly identified cause of paediatric steroid-resistant nephrotic syndrome (SRNS).
Bierzynska A +23 more
europepmc +5 more sources