Using the Drosophila Nephrocyte to Model Podocyte Function and Disease [PDF]
Frontiers in Pediatrics, 2017 Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations ...
Martin Helmstadter +2 more
exaly +10 more sources
Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. [PDF]
PLoS ONE, 2015 Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised.
Jessica R Ivy +6 more
doaj +8 more sources
Reconsidering protein quality: Role of amino acid composition in diet-induced hepatorenal stress [PDF]
Open Veterinary JournalRecent investigations into the physiological impact of diet on laboratory animals have brought renewed attention to the metabolic consequences of common dietary components.
Yves Hude, Yuxiao Hu
doaj +4 more sources
Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in Drosophila Nephrocytes [PDF]
CellsMitochondria are crucial for cellular ATP production. They are highly dynamic organelles, whose morphology and function are controlled through mitochondrial fusion and fission. The specific roles of mitochondria in podocytes, the highly specialized cells
Jun-yi Zhu +3 more
doaj +4 more sources
Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila [PDF]
Journal of the American Society of Nephrology: JASNKey Points Piezo channels, known for detecting mechanical pressure, were found to be expressed at the lacuna channel membranes of nephrocytes.Piezo loss of function caused nephrocyte dysfunction, including disrupted slit diaphragm structure and altered lacuna channel morphology.Piezo deficiency
Yunpo Zhao +2 more
exaly +4 more sources
Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease. [PDF]
PLoS Biology, 2021 Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells ...
Aleksandra Lubojemska +8 more
doaj +4 more sources
Drosophila Nephrocyte as a Model for Studying Glomerular Basement Membrane Physiology [PDF]
Journal of the American Society of Nephrology: JASNJoyce Van De Leemput, Zhe Han
exaly +4 more sources
Functional study of mammalian Neph proteins in Drosophila melanogaster. [PDF]
PLoS ONE, 2012 Neph molecules are highly conserved immunoglobulin superfamily proteins (IgSF) which are essential for multiple morphogenetic processes, including glomerular development in mammals and neuronal as well as nephrocyte development in D. melanogaster.
Martin Helmstädter +8 more
doaj +3 more sources
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function [PDF]
Nature Communications, 2019 Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of ...
J. A. Hurcombe +22 more
doaj +2 more sources
Histochemical research of cells functionally leading tissue liver and kidneys of rats after intravenous application of nanoparticles magnetite [PDF]
Бюллетень сибирской медицины, 2011 After unitary and repeated intravenous application magnetite is shown their distribution in organism of a rat by method of magnetic resonance imaging. Accumulation of particles in a liver and a spleen of animals is shown.
I. V. Milto +3 more
doaj +5 more sources