Results 41 to 50 of about 541 (160)
International Journal of Biomaterials, Volume 2022, Issue 1, 2022., 2022 Copper (Cu) is an essential trace element for the efficient functioning of living organisms. Cu can enter the body in different ways, and when it surpasses the range of biological tolerance, it can have negative consequences. The use of different nanoparticles, especially metal oxide nanoparticles, is increasingly being expanded in the fields of ...
Manal M. S. AL-Musawi +3 more
wiley +1 more source
Data for: Triptriolide antagonizes triptolide-induced nephrocyte apoptosis via inhibiting oxidative stress in vitro and in vivo [PDF]
, 2019 Data for: Triptriolide antagonizes triptolide-induced nephrocyte apoptosis via inhibiting oxidative stress in vitro and in ...
yiqi yang (7059443) +9 more
core +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Podocyte lipid accumulation is a potential therapeutic target for diabetic nephropathy (DN). This study was aimed at clarifying the mechanism of Gandi capsule (GDC) ameliorating DN by regulating the lipid metabolism of podocytes. Network pharmacology methods were performed to screen the key molecules and potential targets of GDC for constructing the ...
Ying Zhang +14 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 23, Page 10798-10813, December 2021., 2021 Abstract Diabetic nephropathy (DN) remains one of the severe complications associated with diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits of human urine‐derived stem cells (hUSCs) in the treatment of DN. At present, the clinical benefits associated with hUSCs in the treatment of DN remains unclear.
Yu‐Rui Duan +7 more
wiley +1 more source
BRIDGING THE NEPHROCYTE GAP [PDF]
Journal of Experimental Biology, 2009 ![Figure][1] The kidney is one of the main sites of blood volume regulation, osmoregulation and excretion in vertebrates. Its functional unit is the nephron, which can be found in countless copies in the kidney.
openaire +1 more source
dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
doaj +1 more source
Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Melica ME +3 more
europepmc +2 more sources
Cell & Bioscience, 2021 Background The Slit diaphragm (SD) is the key filtration structure in human glomerular kidney that is affected in many types of renal diseases. SD proteins are known to undergo endocytosis and recycling to maintain the integrity of the filtration ...
Luyao Wang +4 more
doaj +1 more source
Rabphilin silencing causes dilated cardiomyopathy in a Drosophila model of nephrocyte damage
Scientific Reports, 2021 Heart failure (HF) and the development of chronic kidney disease (CKD) have a direct association. Both can be cause and consequence of the other.
Estela Selma-Soriano +5 more
doaj +1 more source
Disease Models & Mechanisms, 2020 Drosophila nephrocytes share functional, structural and molecular similarities with human podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex, and its expression is altered in mouse and human proteinuric disease ...
Estela Selma-Soriano +5 more
doaj +1 more source