Results 61 to 70 of about 541 (160)

Glycyrol Alleviates Acute Kidney Injury by Inhibiting Ferroptsis. [PDF]

Int J Mol Sci
Acute kidney injury (AKI) is a common clinical problem with high morbidity and mortality. The discovery of ferroptosis has provided novel insights into the mechanisms underlying AKI and paves the way for developing ferroptosis-based approaches to treat ...
Cao L, Han K, Fan L, Zhao C, Yin S, Hu H.   +5 more
europepmc   +2 more sources

Filling the Gap: Drosophila Nephrocytes as Model System in Kidney Research [PDF]

Journal of the American Society of Nephrology, 2019
New and efficient sequencing technologies are constantly identifying novel gene variants in patients that may be the genetic cause of renal diseases. Recent studies show that, even for adult patients with CKD, monogenic causes can be detected in around 10% of patients.[1][1] Novel causative ...
Zvonimir, Marelja, Matias, Simons
openaire   +2 more sources

dKlf15 overexpression increases the number of functional nephrocytes in adults and prevents age-dependent nephrocyte dysfunction. [PDF]

, 2015
(A) Pericardial nephrocytes from control (progeny of Dot-Gal4 outcrossed to w1118; A’) and dKlf15 over-expressing flies (Dot-Gal4; UAS-dKlf15; A”) stained with anti-dKlf15 (1:100) and anti-Amnionless antibodies (1:100). Scale bar = 50 μm.
Paul S. Hartley (244067), James H. Catterson (244043), Maik Drechsler (158824), Rolf Bodmer (76494), Jessica R. Ivy (786406), Karen Ocorr (104906), Achim Paululat (87926)   +6 more
core   +1 more source

Gba1b is expressed in the brain, fat body and gut. [PDF]

, 2023
(A) The Gba1b gene expression pattern, as assessed by the expression of mCherry under the Gba1b endogenous promoter (red channel), overlaps with immunostaining for the glial marker Repo (green channel, top panel), but not with the neuronal marker Elav ...
Jacob Wildfire (17692021), Mirjam L. Adams (17692018), Linda Partridge (9382), Kerri J. Kinghorn (9708167), Catalina-Andreea Romila (17692015), Miranda Dyson (17692024), Magda L. Atilano (17020294), Alexander Hull (17692012), Enric Ureña (2635198), Jorge Ivan-Castillo-Quan (17692027)   +9 more
core   +1 more source

On the Nephrocytes of Pediculus humanus

Parasitology, 1921
In Pediculus humanus are found two groups of excretory-accumulatory cells known as nephrocytes.The one group, the peri-oesophageal, lies ventrally and consists of large cells aggregated usually in two masses about the oesophagus anterior to the reniform salivary glands.The second group lies dorsally and consists of disseminated cell aggregates linked ...
George H. F. Nuttall, D. Keilin
openaire   +1 more source

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

The Evolution of Giant Clam Science: From Foundational Studies to Emerging Frontiers

Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.
This review synthesizes nearly two centuries of giant clam research, identifying dominant themes, knowledge gaps, and emerging opportunities. Ecology, physiology, aquaculture, genomics, and biomineralization dominate the field, whereas anatomy and biotechnology remain underexplored. Future progress requires stronger integration of genomics, physiology,
Anthony Fam, Sujune Tsai, Bonien Chen, Zhi‐Hong Wen, Chiahsin Lin   +4 more
wiley   +1 more source

Electron microscopy of Drosophila garland cell nephrocytes: Optimal preparation, immunostaining and STEM tomography [PDF]

, 2018
Due to its structural and molecular similarities to mammalian podocytes, the Drosophila nephrocyte emerged as a model system to study podocyte development and associated diseases.
Yulia Zaytseva, Zaytseva, Yulia, Maaßen, Christine, Krahn, Michael P., Christine Maaßen, Michael P. Krahn, Hochapfel, Florian, Witzgall, Ralph, Lucia Denk, Florian Hochapfel, Rachel, Reinhard, Denk, Lucia, Reinhard Rachel, Ralph Witzgall   +13 more
core   +1 more source

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death [PDF]

Journal of the American Society of Nephrology, 2016
People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of developing renal diseases. However, the mechanisms underlying APOL1-associated renal diseases are unknown. Because the APOL1 gene is unique to humans and some primates, new animal models are needed to understand the function of APOL1 in vivo.
Yulong, Fu, Jun-Yi, Zhu, Adam, Richman, Yi, Zhang, Xuefang, Xie, Jharna R, Das, Jinliang, Li, Patricio E, Ray, Zhe, Han   +8 more
openaire   +2 more sources