Results 31 to 40 of about 7,831,583 (247)

Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Malaria Journal, 2017
Background Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised ...
Jaline Gerardin, Caitlin A. Bever, Daniel Bridenbecker, Busiku Hamainza, Kafula Silumbe, John M. Miller, Thomas P. Eisele, Philip A. Eckhoff, Edward A. Wenger   +8 more
doaj   +1 more source

Mending a broken heart: current strategies and limitations of cell-based therapy

Stem Cell Research & Therapy, 2020
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the
Lee Chuen Liew, Beatrice Xuan Ho, Boon-Seng Soh   +2 more
doaj   +1 more source

Preventing a cluster from becoming a new wave in settings with zero community COVID-19 cases

BMC Infectious Diseases, 2022
Background In settings with zero community transmission, any new SARS-CoV-2 outbreaks are likely to be the result of random incursions. The level of restrictions in place at the time of the incursion is likely to considerably affect possible outbreak ...
Romesh G. Abeysuriya, Dominic Delport, Robyn M. Stuart, Rachel Sacks-Davis, Cliff C. Kerr, Dina Mistry, Daniel J. Klein, Margaret Hellard, Nick Scott   +8 more
doaj   +1 more source

Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns [version 2; peer review: 2 approved]

Gates Open Research, 2022
Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services.
Brittany Hagedorn, Kurt Frey, Susan Annemarie Wang, Kevin A. McCarthy, Raymond Hutubessy   +4 more
doaj   +1 more source

Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

BMC Medicine, 2023
Background Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous study not to be cost-effective in ...
Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo, Mark Jit   +9 more
doaj   +1 more source

A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features

Human Genomics, 2018
Background Intellectual disability (ID) is a common condition with a population prevalence frequency of 1–3% and an enrichment for males, driven in part by the contribution of mutant alleles on the X-chromosome.
Georgios Kellaris, Kamal Khan, Shahid M. Baig, I-Chun Tsai, Francisca Millan Zamora, Paul Ruggieri, Marvin R. Natowicz, Nicholas Katsanis   +7 more
doaj   +1 more source

Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome

Human Genomics, 2017
Background The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this
Benjamin M. Helm, Jason R. Willer, Azita Sadeghpour, Christelle Golzio, Eric Crouch, Samantha Schrier Vergano, Nicholas Katsanis, Erica E. Davis   +7 more
doaj   +1 more source

The many guises of R0 (a didactic note) [PDF]

, 2016
The basic reproduction number R0 is, by definition, the expected life time number of offspring of a newborn individual. An operationalization entails a specification of what events are considered as “reproduction” and what events are considered as ...
Mathematical Modeling, Cushing, J. M., Sub Mathematical Modeling, Diekmann, Odo   +3 more
core   +2 more sources

Applications of miRNAs in cardiac development, disease progression and regeneration

Stem Cell Research & Therapy, 2019
Development of the complex human heart is tightly regulated at multiple levels, maintaining multipotency and proliferative state in the embryonic cardiovascular progenitors and thereafter suppressing progenitor characteristics to allow for terminal ...
Jeremy Kah Sheng Pang, Qian Hua Phua, Boon-Seng Soh   +2 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source