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Moral Limits of Brain Organoid Research [PDF]

Journal of Law, Medicine & Ethics, 2019
Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
openaire   +4 more sources

Cultures and cures: neurodiversity and brain organoids [PDF]

BMC Medical Ethics, 2021
Abstract Background Research with cerebral organoids is beginning to make significant progress in understanding the etiology of autism spectrum disorder (ASD). Brain organoid models can be grown from the cells of donors with ASD.
Barnhart, Andrew J., Dierickx, Kris
openaire   +3 more sources

The welfare of brain organoids

Molecular Psychology: Brain, Behavior, and Society, 2023
One of the most urgent challenges arising in bioethics has been the ethical assessment of the use of brain organoids, largely because of the possibility of sentience and the potential that if they can feel, then they might suffer. But while there is a growing literature on the possibility of sentience in brain organoids and why we should take a ...
Heather Browning, Walter Veit
openaire   +1 more source

3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

BMC Biomedical Engineering, 2021
Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla, Camilo Salazar-Hernandez, Sally L. Perrin, Kaitlin G. Scheer, Gökhan Cildir, John Toubia, Kristyna Sedivakova, Melinda N. Tea, Sakthi Lenin, Elise Ponthier, Erica C. F. Yeo, Vinay Tergaonkar, Santosh Poonnoose, Rebecca J. Ormsby, Stuart M. Pitson, Michael P. Brown, Lisa M. Ebert, Guillermo A. Gomez   +17 more
doaj   +1 more source

Modeling human neurodevelopmental diseases with brain organoids

Cell Regeneration, 2022
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.
Xiaoxiang Lu, Jiajie Yang, Yangfei Xiang
doaj   +1 more source

Telencephalic organoids as model systems to study cortical development and diseases [PDF]

Organoid
The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete.
Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park   +2 more
doaj   +1 more source

Brain Organoids and Assembloids—From Disease Modeling to Drug Discovery

Cells
Brain organoids are self-organized, three-dimensional (3D) aggregates derived from human embryonic stem cells, induced pluripotent stem cells, or primary organs with cell types and cellular architectures resembling those of the developing human brain ...
Aderonke O. Ajongbolo, Sigrid A. Langhans   +1 more
doaj   +1 more source

Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Frontiers in Immunology, 2022
Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly.
Xuan Su, Xuan Su, Peng Yue, Peng Yue, Jing Kong, Jing Kong, Xin Xu, Xin Xu, Yu Zhang, Yu Zhang, Wenjing Cao, Wenjing Cao, Yuxin Fan, Yuxin Fan, Meixiao Liu, Meixiao Liu, Jingjing Chen, Jingjing Chen, Aihua Liu, Aihua Liu, Fukai Bao, Fukai Bao   +21 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modeling APOE ε4 familial Alzheimer’s disease in directly converted 3D brain organoids

Frontiers in Aging Neuroscience
Brain organoids have become a valuable tool for studying human brain development, disease modeling, and drug testing. However, generating brain organoids with mature neurons is time-intensive and often incomplete, limiting their utility in studying age ...
Yunkyung Kim, Hongwon Kim, Hongwon Kim, Byounggook Cho, Saemin An, Soi Kang, Sumin Kim, Jongpil Kim   +7 more
doaj   +1 more source