Nature Communications, 2021 3D brain organoids have been used to investigate human brain development and pathology. Here the authors establish human ventral midbrain organoids coupled with single cell sequencing to study developing and mature dopamine neurons and use silk ...
Alessandro Fiorenzano +13 more
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Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
, 2019 Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L. +8 more
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Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
Cell Death Discovery, 2023 Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate human brain-specific features in animal models. Though the anatomy and physiology of the human brain has
Yogita K. Adlakha
doaj +1 more source
Human in vitro models for understanding mechanisms of autism spectrum disorder. [PDF]
, 2020 Early brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental ...
Geschwind, Daniel H, Gordon, Aaron
core
Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]
, 2013 Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa +12 more
core +4 more sources
Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]
, 2020 Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois +6 more
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
openaire +2 more sources
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]
, 2020 BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark +20 more
core +1 more source
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source