Results 21 to 30 of about 27,210 (261)
Frontiers in Neuroscience, 2021 Over the past years, brain development has been investigated in rodent models, which were particularly relevant to establish the role of specific genes in this process.
Lisiane O. Porciúncula +4 more
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Genetic Modification of Brain Organoids [PDF]
Frontiers in Cellular Neuroscience, 2019 Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
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Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Cell Reports, 2020 Summary: Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the brain
Yoshiaki Tanaka +4 more
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Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells
Annals of Clinical and Translational Neurology, 2023 Objective Brain organoids are miniaturized in vitro brain models generated from pluripotent stem cells, which resemble full‐sized brain more closely than conventional two‐dimensional cell cultures. Although brain organoids mimic the human brain's cell‐to‐
Ayşe J. Muñiz +10 more
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Challenges in Modeling Human Neural Circuit Formation via Brain Organoid Technology
Frontiers in Cellular Neuroscience, 2020 Human brain organoids are three-dimensional self-organizing tissues induced from pluripotent cells that recapitulate some aspects of early development and some of the early structure of the human brain in vitro.
Takeshi K. Matsui +2 more
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Brain Organoids and the Study of Neurodevelopment [PDF]
Trends in Molecular Medicine, 2018 Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to elucidate the genetic basis of certain neurodevelopmental disorders, such as ...
Cleber A. Trujillo, Alysson R. Muotri
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Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
Cell Death Discovery, 2023 Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate human brain-specific features in animal models. Though the anatomy and physiology of the human brain has
Yogita K. Adlakha
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What Makes Organoids Good Models of Human Neurogenesis?
Frontiers in Neuroscience, 2022 Human neurogenesis occurs mainly in embryonic, fetal, and neonatal stages and generates tremendously diverse neural cell types that constitute the human nervous system.
Qian Yang +10 more
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Nature Communications, 2021 3D brain organoids have been used to investigate human brain development and pathology. Here the authors establish human ventral midbrain organoids coupled with single cell sequencing to study developing and mature dopamine neurons and use silk ...
Alessandro Fiorenzano +13 more
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Nature Communications, 2021 Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids.
Ann-Na Cho +22 more
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