Results 21 to 30 of about 39,896 (297)
Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Cell Reports, 2020 Summary: Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the brain
Yoshiaki Tanaka +4 more
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Human brain organoid networks [PDF]
, 2021 AbstractHuman brain organoids replicate much of the cellular diversity and developmental anatomy of the human brain. However, the physiological behavior of neuronal circuits within organoids remains relatively under-explored. With high-density CMOS microelectrode arrays (26,400 electrodes) and shank electrodes (960 electrodes), we probed broadband and ...
Tal Sharf +15 more
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Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells
Annals of Clinical and Translational Neurology, 2023 Objective Brain organoids are miniaturized in vitro brain models generated from pluripotent stem cells, which resemble full‐sized brain more closely than conventional two‐dimensional cell cultures. Although brain organoids mimic the human brain's cell‐to‐
Ayşe J. Muñiz +10 more
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Challenges in Modeling Human Neural Circuit Formation via Brain Organoid Technology
Frontiers in Cellular Neuroscience, 2020 Human brain organoids are three-dimensional self-organizing tissues induced from pluripotent cells that recapitulate some aspects of early development and some of the early structure of the human brain in vitro.
Takeshi K. Matsui +2 more
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Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities [PDF]
, 2019 Three-dimensional (3D) printing of biological material, or 3D bioprinting, is a rapidly expanding field with interesting applications in tissue engineering and regenerative medicine. Bioprinters use cells and biocompatible materials as an ink (bioink) to
Rosa, Alessandro, Salaris, Federico
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Nature Communications, 2021 Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids.
Ann-Na Cho +22 more
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Connecting the Brain to Itself through an Emulation. [PDF]
, 2017 Pilot clinical trials of human patients implanted with devices that can chronically record and stimulate ensembles of hundreds to thousands of individual neurons offer the possibility of expanding the substrate of cognition.
Serruya, Mijail D.
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What Makes Organoids Good Models of Human Neurogenesis?
Frontiers in Neuroscience, 2022 Human neurogenesis occurs mainly in embryonic, fetal, and neonatal stages and generates tremendously diverse neural cell types that constitute the human nervous system.
Qian Yang +10 more
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Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]
, 2017 While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen +11 more
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Moral Limits of Brain Organoid Research [PDF]
Journal of Law, Medicine & Ethics, 2019 Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
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