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Generation of Human Blood Vessel and Vascularized Cerebral Organoids
Bio-Protocol, 2023 Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun +5 more
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Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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Unraveling Human Brain Development and Evolution Using Organoid Models
Frontiers in Cell and Developmental Biology, 2021 Brain organoids are proving to be physiologically relevant models for studying human brain development in terms of temporal transcriptional signature recapitulation, dynamic cytoarchitectural development, and functional electrophysiological maturation ...
Sarah Fernandes +5 more
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To brain or not to brain organoids
Frontiers in Science, 2023 Brain organoids are a unique template for engineering a new era of bio-inspired supercomputer technology. The power requirements for exploiting brain organoids may be higher than those of the most powerful computers. Further research is needed to accelerate sustainable solutions in brain organoid-leveraged supercomputing technologies.
Magliaro, Chiara, Ahluwalia, Arti
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Brain organoids are new tool for drug screening of neurological diseases
Neural Regeneration Research, 2023 At the level of in vitro drug screening, the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening. There are few systematic reports on brain organoids, as
Jin-Qi Zhou +7 more
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Human Brain Organoids to Decode Mechanisms of Microcephaly
Frontiers in Cellular Neuroscience, 2020 Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early events of human brain development. Recent improvements with patient-specific 3D brain organoids have begun to elucidate unprecedented details of the defective ...
Elke Gabriel +3 more
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Genetic Modification of Brain Organoids [PDF]
Frontiers in Cellular Neuroscience, 2019 Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
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eLife, 2022 Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
Bilal Cakir, In-Hyun Park
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Frontiers in Neuroscience, 2021 Over the past years, brain development has been investigated in rodent models, which were particularly relevant to establish the role of specific genes in this process.
Lisiane O. Porciúncula +4 more
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