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Brain Organoids, the Path Forward?
Voices in BioethicsPhoto by Maxim Berg on Unsplash INTRODUCTION The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique.
Ashley Diloreto
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Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics. [PDF]
Adv Sci (Weinh)Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Pantula A +4 more
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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To brain or not to brain organoids
Frontiers in Science, 2023 Brain organoids are a unique template for engineering a new era of bio-inspired supercomputer technology. The power requirements for exploiting brain organoids may be higher than those of the most powerful computers. Further research is needed to accelerate sustainable solutions in brain organoid-leveraged supercomputing technologies.
Magliaro, Chiara, Ahluwalia, Arti
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Human Brain Organoids to Decode Mechanisms of Microcephaly
Frontiers in Cellular Neuroscience, 2020 Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early events of human brain development. Recent improvements with patient-specific 3D brain organoids have begun to elucidate unprecedented details of the defective ...
Elke Gabriel +3 more
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
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eLife, 2022 Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
Bilal Cakir, In-Hyun Park
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Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia-Like Cells. [PDF]
Adv Sci (Weinh)Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Lin H +7 more
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