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Brain Organoids, the Path Forward?
Voices in BioethicsPhoto by Maxim Berg on Unsplash INTRODUCTION The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique.
Ashley Diloreto
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The Promise and Potential of Brain Organoids
Advanced Healthcare MaterialsBrain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self‐organize to model features of the (developing) human brain.
Lena Smirnova, Thomas Hartung
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ACS NanoBrain organoids are widely used to model brain development and diseases. However, a major challenge in their application is the insufficient supply of oxygen and nutrients to the core region, restricting the size and maturation of the organoids. In order
Wanying Zhu, Mengdan Tao, Zhongze Gu
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One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids [PDF]
Advanced ScienceHuman‐induced pluripotent stem cell (iPSC)‐derived brain organoids have attracted significant attention as promising models for drug screening owing to their remarkable resemblance to the human brain.
Hyogeun Shin +9 more
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Modeling APOE ε4 familial Alzheimer’s disease in directly converted 3D brain organoids
Frontiers in Aging NeuroscienceBrain organoids have become a valuable tool for studying human brain development, disease modeling, and drug testing. However, generating brain organoids with mature neurons is time-intensive and often incomplete, limiting their utility in studying age ...
Yunkyung Kim +7 more
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Modeling Neurological Diseases With Human Brain Organoids
Frontiers in Synaptic Neuroscience, 2018 The complexity and delicacy of human brain make it challenging to recapitulate its development, function and disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain,
Hansen Wang
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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Generation of vascularized brain organoids to study neurovascular interactions
eLife, 2022 Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids.
Xin-Yao Sun +9 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Scientific Reports, 2022 The establishment of robust human brain organoids to model cerebellar diseases is essential to study new therapeutic strategies for cerebellum-associated disorders.
João Brás +9 more
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