Results 31 to 40 of about 106,655 (301)

Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease

Organoids, 2023
Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health and disease. To continue making progress, it is crucial to acknowledge the crucial role of the immune system in all ...
Ania Bogoslowski, Meilin An, Josef M. Penninger   +2 more
doaj   +1 more source

Cornea organoids from human induced pluripotent stem cells. [PDF]

, 2017
The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M, Birk, David E, Chakravarti, Shukti, Foster, James W, Wahlin, Karl, Zack, Donald J   +5 more
core   +3 more sources

The Next Generation of Organoids Will Be More Complex and Even Closer to Resembling Real Organs: An Interview with Prof. Dr. Hans Clevers

Organoids
In this issue, we are pleased and honored to have an interview with Professor Hans Clevers, who is the Advisory Board Member of Organoids [...]
Süleyman Ergün, Organoids Editorial Office   +1 more
doaj   +1 more source

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Frontiers in Veterinary Science
IntroductionCurrent management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity.
Mengjuan Chen, Mengjuan Chen, Hui Han, Hui Han, Mengke Qin, Mengke Qin, Huixin Li, Huixin Li, Qiqi Lu, Qiqi Lu, Xin Huang, Xin Huang, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +15 more
doaj   +1 more source

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]

, 2019
Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna, Kessenbrock, Kai, Roose, Jeroen P, Samocha, Alexandr   +3 more
core   +1 more source

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Journal of Experimental & Clinical Cancer Research
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy ...
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart   +19 more
doaj   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody

Frontiers in Veterinary Science
IntroductionCD3, a surface antigen critical for T cell activation and signal transduction, serves as a key diagnostic marker for T cell-associated malignancies and a therapeutic target in immunotherapy.
Huixin Li, Huixin Li, Mengjuan Chen, Mengjuan Chen, Rongmiao Yue, Rongmiao Yue, Sihao Li, Bowen Shi, Mengke Qin, Mengke Qin, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +13 more
doaj   +1 more source

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]

, 2017
While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen, Cheung, Eric C., Hock, Andreas K., Humpton, Timothy J., Lee, Pearl, McGhee, Ewan, Monteverde, Tiziana, Murphy, Daniel J., Paulus-Hock, Viola, Scopelliti, Alessandro, Strathdee, Douglas, Vousden, Karen H.   +11 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Widespread parainflammation in human cancer. [PDF]

, 2016
BackgroundChronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly promotes mouse gut tumorigenesis upon ...
Aran, Dvir, Ben-Neriah, Yinon, Biton, Moshe, Butte, Atul J, Hellman, Asaf, Lasry, Audrey, Pikarsky, Eli, Zinger, Adar   +7 more
core   +3 more sources