Results 31 to 40 of about 94,019 (259)

Equine Oviductal Organoid Generation and Cryopreservation

, 2022
Organoids are a type of three-dimensional (3D) cell culture that more closely mimic the in vivo environment and can be maintained in the long term. To date, oviductal organoids have only been reported in laboratory mice, women, and cattle.
Thompson, Riley E., Veeramachaneni, D. N. Rao, Pukazhenthi, Budhan S., Hollinshead, Fiona K., Fiona K. Hollinshead, Mindy A. Meyers, Riley E. Thompson, Budhan S. Pukazhenthi, Meyers, Mindy A., D. N. Rao Veeramachaneni   +9 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mimicking Senescence Factors to Characterize the Mechanisms Responsible for Hair Regression and Hair Loss: An In Vitro Study

Organoids
Background/Objectives: VitroScreenORA® (by VitroScreen srl) Dermo Papilla spheroids, based on two micro-physiological systems (non-vascularized DP and vascularized VASC-DP), were used to study the molecular mechanisms behind hair cycle regression ...
Giacomo Masi, Camilla Guiducci, Francesca Rescigno   +2 more
doaj   +1 more source

Development of 3D culture techniques for human brain organoids derivation

, 2022
reservedLo sviluppo neuronale dell’embrione umano non può essere richiamato con modelli in 2D, perché non presentano un’appropriata citoarchitettura e una eterogenea popolazione neuronale.
FRISON, ROBERTA
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Accelerating personalized medicine: miniaturized patient-derived organoid drug screening for predicting cancer treatment responses and beyond

npj Biomedical Innovations
Patient-derived-organoids (PDOs) are valuable tools for predicting individual responses to cancer treatments. However, current screening methods require large numbers of PDOs, resulting in long turnaround times and limiting clinical use. This study aimed
Yasmine Abouleila, Lidwien P. Smabers, Timo Voskuilen, Mayke Doorn, Roel Verkerk, Gakuro Harada, Masahiko Watanabe, Hideaki Kyan, Takahiko Kumagai, Yuichi Hikichi, René Overmeer, Jeanine M. L. Roodhart, Kiyotaka Matsuno, Carla S. Verissimo, Sylvia F. Boj   +14 more
doaj   +1 more source

Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair

Organoids
The stomach epithelium is a highly dynamic tissue that undergoes continuous self-renewal and responds robustly to injury through tightly regulated repair processes. Organoids have emerged as powerful tools for modelling gastrointestinal biology.
Nikki Liddelow, Jie Yu Tan, Dustin J. Flanagan   +2 more
doaj   +1 more source

Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced nephrotoxicity

, 2022
Advances in regenerative medicine have led to the construction of many types of organoids, which reproduce important aspects of endogenous organs but may be limited or disorganised in nature. While their usefulness for restoring function remains unclear,
Lawrence, Melanie, Morlock, Michaela, Palakkan, Anwar, Liu, S, Davies, Jamie, Hohenstein, Peter, Elhendawi, Mona, Sjögren, Anna-Karin, Seidl, LF, Liu, Weijia   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells

Organoids
Tooth and periodontal organoids from stem and progenitor cells represent a significant advancement in regenerative dentistry, offering solutions for tooth loss and periodontal diseases.
Fuad Gandhi Torizal, Syarifah Tiara Noorintan, Zakiya Gania   +2 more
doaj   +1 more source