Results 31 to 40 of about 81,677 (304)

The Intricacies of Inflammatory Bowel Disease: A Preliminary Study of Redox Biology in Intestinal Organoids

Organoids, 2023
We evaluated the redox status, precisely glutathione levels, which have a major impact in cellular detoxification and antioxidant defence in IBD-derived and healthy intestinal organoids.
Georg Csukovich, Janina Huainig, Selina Troester, Barbara Pratscher, Iwan Anton Burgener   +4 more
doaj   +1 more source

Organoids by design

Science, 2019
Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
openaire   +3 more sources

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Frontiers in Veterinary Science
IntroductionCurrent management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity.
Mengjuan Chen, Mengjuan Chen, Hui Han, Hui Han, Mengke Qin, Mengke Qin, Huixin Li, Huixin Li, Qiqi Lu, Qiqi Lu, Xin Huang, Xin Huang, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +15 more
doaj   +1 more source

Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease

Organoids, 2023
Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health and disease. To continue making progress, it is crucial to acknowledge the crucial role of the immune system in all ...
Ania Bogoslowski, Meilin An, Josef M. Penninger   +2 more
doaj   +1 more source

Vascularization of engineered organoids

, 2023
Organoids are biomimetic tissue analogs that are generated via the self‐organization of stem cells or adult cells relying on developmental biology principles.
Xu Zhang, Jiayue Liu, Haitao Liu, Jianhua Qin   +3 more
core   +1 more source

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Journal of Experimental & Clinical Cancer Research
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy ...
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart   +19 more
doaj   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody

Frontiers in Veterinary Science
IntroductionCD3, a surface antigen critical for T cell activation and signal transduction, serves as a key diagnostic marker for T cell-associated malignancies and a therapeutic target in immunotherapy.
Huixin Li, Huixin Li, Mengjuan Chen, Mengjuan Chen, Rongmiao Yue, Rongmiao Yue, Sihao Li, Bowen Shi, Mengke Qin, Mengke Qin, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +13 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced nephrotoxicity

, 2022
Advances in regenerative medicine have led to the construction of many types of organoids, which reproduce important aspects of endogenous organs but may be limited or disorganised in nature. While their usefulness for restoring function remains unclear,
Lawrence, Melanie, Morlock, Michaela, Palakkan, Anwar, Liu, S, Davies, Jamie, Hohenstein, Peter, Elhendawi, Mona, Sjögren, Anna-Karin, Seidl, LF, Liu, Weijia   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source