Results 31 to 40 of about 65,212 (162)

Organoid-derived extracellular vesicles: From organoid, to organoid

Organoid Research
Organoids are miniature, three-dimensional tissue constructs generated from stem cells or primary cells that recapitulate key structural and functional features similar to those of in situ organs. Extracellular vesicles (EVs) are non-replicating nanocarriers enclosed by a phospholipid bilayer (20–400 nm) that mediate the delivery of bioactive
Ting Cheng, Wojciech Chrzanowski, Han Liu, Jiacan Su   +3 more
openaire   +1 more source

Bioengineering Tooth and Periodontal Organoids from Stem and Progenitor Cells

Organoids
Tooth and periodontal organoids from stem and progenitor cells represent a significant advancement in regenerative dentistry, offering solutions for tooth loss and periodontal diseases.
Fuad Gandhi Torizal, Syarifah Tiara Noorintan, Zakiya Gania   +2 more
doaj   +1 more source

In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design

Organoids
Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the ...
Eyad Awad, Matthew Bedding-Tyrrell, Alberto Coccarelli, Feihu Zhao   +3 more
doaj   +1 more source

Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives

Organoids
The development of brain organoids from human-induced pluripotent stem cells (iPSCs) has expanded research into neurodevelopment, disease modeling, and drug testing.
Michael W. Nestor, Richard L. Wilson
doaj   +1 more source

Breast Cancer Tissues and Organoids BioBank: Constitution, Research Activities and Samples Access

Organoids
In 2023, at the Center for Biological Resources (CRB) at the Institute of Genetics and Biophysics (IGB, Naples, Italy) of the National Research Council (CNR), the Breast Cancer Tissues and Organoids Biobank (BCTO BioBank) was founded.
Lucia Miranda, Luigi Mandrich, Simona Massa, Teresa Nutile, Clotilde Crovella, Ilaria De Rosa, Raffaella Lucci, Filippo De Rosa, Pasquale Somma, Vincenzo Mercadante, Ciro Abate, Salvatore Arbucci, Luigi Panico, Emilia Caputo   +13 more
doaj   +1 more source

Precision Medicine for Peritoneal Carcinomatosis—Current Advances in Organoid Drug Testing and Clinical Applicability

Organoids
Peritoneal carcinomatosis from gastrointestinal tumours is considered a poor prognostic factor, with a median overall survival of six to nine months in the absence of intervention.
Harleen Kaur, Josephine A. Wright, Daniel L. Worthley, Elizabeth Murphy, Susan L. Woods   +4 more
doaj   +1 more source

Visualization of Vascular Perfusion of Human Pancreatic Cancer Tissue in the CAM Model and Its Impact on Future Personalized Drug Testing

Organoids
Although significant improvements have been made in the treatment of pancreatic cancer, its prognosis remains poor with an overall 5-year survival rate of less than 10%. New experimental approaches are necessary to develop novel therapeutics.
Andreas Ettner-Sitter, Agata Montagner, Jonas Kuenzel, Kathrin Brackmann, Maximilian Schäfer, Robert Schober, Florian Weber, Thiha Aung, Christina Hackl, Silke Haerteis   +9 more
doaj   +1 more source

Organoids in virology

npj Viruses
Abstract To adequately prepare against imminent disease outbreaks from diverse and ever-changing viral pathogens, improved experimental models that can accurately recapitulate host-virus responses and disease pathogenesis in human are essential.
Chu, Julie T. S., Lamers, Mart M.
openaire   +2 more sources

Organoids and 3D In Vitro Models as a Platform for Precision Medicine (PM): An Update

Organoids
Globally, a number of diseases impact us and while treatment options exist, it is often found that similar treatments have variable effects on different patients with the same disease.
Payal Ganguly
doaj   +1 more source

Single-Cell Assessment of Human Stem Cell-Derived Mesolimbic Models and Their Responses to Substances of Abuse

Organoids
The mesolimbic pathway connects ventral tegmental area dopaminergic neurons and striatal medium spiny neurons, playing a critical role in reward and stress behaviors.
Thomas P. Rudibaugh, Ryan W. Tam, R. Chris Estridge, Samantha R. Stuppy, Albert J. Keung   +4 more
doaj   +1 more source