Results 11 to 20 of about 94,019 (259)

Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential [PDF]

, 2023
Painted turtles are remarkable for their well-developed freeze tolerance and associated resilience to hypoxia/anoxia, oxidative stress, and ability to supercool.
Kundu, Debosmita, Honold, Sydney, Ralston, Abigail, Topping, Nicholas E., Gessler, Thea B., Allenspach, Karin, Gabriel, Vojtech, Piñeyro, Pablo, Ospina, Oscar, Mochel, Jonathan, Wickham, Hannah, Sifuentes-Romero, Itzel, Sahoo, Dipak Kumar, Tamplin, Jeffrey, Zdyrski, Christopher, Bista, Basanta, Meyerholz, David K., Valenzuela, Nicole   +17 more
core  

Generating human striatal organoids.

, 2022
(A) The schematic of brain organoid protocol with a ventral drug-patterning application (purmorphamine) during culture. (B) The morphology of organoids with different concentrations of ventral drug-patterning applications in culture.
Yuqi Wang (270190), Lixiang Ma (4006619), Xuan Li (137217), Rong Ji (1496803), Yang Liu (4829), Hexige Saiyin (141992), Xinyu Chen (47670)   +6 more
core   +1 more source

SMAD1 Is Dispensable for CDX2 Induction but Required for the Repression of Ectopic Small-Intestinal Gene Expression in Human-Pluripotent-Stem-Cell-Derived Colonic Organoids

Organoids, 2023
The generation of gastrointestinal tissues from human pluripotent stem cells has provided unprecedented insight into the molecular mechanisms that drive the patterning of the primitive gut tube.
Na Qu, Abdelkader Daoud, Braxton Jeffcoat, Jorge O. Múnera   +3 more
doaj   +1 more source

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Frontiers in Veterinary Science
IntroductionCurrent management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity.
Mengjuan Chen, Mengjuan Chen, Hui Han, Hui Han, Mengke Qin, Mengke Qin, Huixin Li, Huixin Li, Qiqi Lu, Qiqi Lu, Xin Huang, Xin Huang, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +15 more
doaj   +1 more source

Vascularizing Organoids to Promote Long-Term Organogenesis on a Chip

Organoids, 2023
Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model.
Xinhui Wang, Brent M. Bijonowski, Nicholas A. Kurniawan   +2 more
doaj   +1 more source

The role of RF-EMF (5G) on neuronal development and neuronal health using brain organoids. [PDF]

, 2023
The expansion of wireless communication technologies has led to a significant increase in public exposure to radiofrequency electromagnetic fields (RF-EMF), with the latest technology being the 5G New Radio (NR) mobile phone network.
Thomas, Selina
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Uncovering Glut-1 Deficiency Syndrome Mechanisms and Therapeutic Targets Using Patient-Derived Brain Organoids [PDF]

Glut-1 Deficiency Syndrome (Glut-1DS) is a rare autosomal dominant neurological disorder caused by heterozygous mutations in the SLC2A1 gene, leading to impaired glucose transport across the blood-brain barrier (BBB).
Isabella Zafferri
core   +2 more sources

Beating Heart Organoids

, 2022
Supplemental Video LegendsVideo 1: Beating RA- heart organoids at day 30 from WTC line with an ACTN2-eGFP reporter.Video 2: Beating RA+ heart organoids at day 30 from WTC line with an ACTN2-eGFP reporter.Video 3: Beating RA- heart organoids at day 15 ...
WEI FENG (12246134), Dennis Kostka (12250535), Guang Li (12246131), Hannah Schriever (12246077)   +3 more
core   +1 more source

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Journal of Experimental & Clinical Cancer Research
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy ...
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart   +19 more
doaj   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody

Frontiers in Veterinary Science
IntroductionCD3, a surface antigen critical for T cell activation and signal transduction, serves as a key diagnostic marker for T cell-associated malignancies and a therapeutic target in immunotherapy.
Huixin Li, Huixin Li, Mengjuan Chen, Mengjuan Chen, Rongmiao Yue, Rongmiao Yue, Sihao Li, Bowen Shi, Mengke Qin, Mengke Qin, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +13 more
doaj   +1 more source