Results 11 to 20 of about 106,655 (301)
Nature Reviews Methods Primers, 2022 Organoids have attracted increasing attention because they are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues.
Zixuan Zhao +13 more
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Bioengineering, 2023 Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel +2 more
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Organoid assessment technologies
Clinical and Translational Medicine, 2023 AbstractDespite enormous advances in the generation of organoids, robust and stable protocols of organoids are still a major challenge to researchers. Research for assessing structures of organoids and the evaluations of their functions on in vitro or in vivo is often limited by precision strategies. A growing interest in assessing organoids has arisen,
Yuyuan Gu +5 more
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Organoids, 2023 The generation of gastrointestinal tissues from human pluripotent stem cells has provided unprecedented insight into the molecular mechanisms that drive the patterning of the primitive gut tube.
Na Qu +3 more
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Opportunities for organoids as new models of aging. [PDF]
, 2018 The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica +145 more
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Vascularizing Organoids to Promote Long-Term Organogenesis on a Chip
Organoids, 2023 Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model.
Xinhui Wang +2 more
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Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
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Human Brain Organoids and Consciousness: Moral Claims and Epistemic Uncertainty
Organoids, 2023 Human brain organoids provide a remarkable opportunity to model prenatal human brain biology in vitro by recapitulating features of in utero molecular, cellular and systems biology. An ethical concern peculiar to human brain organoids is whether they are
Eliza Goddard +3 more
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