Results 11 to 20 of about 7,834 (112)

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Molecular Medicine, 2022
Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo   +13 more
doaj   +1 more source

Contraindicated Drug Responses in Dravet Syndrome Brain Organoids Utilizing Micro Electrode Array Assessment Methods

Organoids, 2023
Ensuring drug safety for patients with specific neurological disorders is of paramount importance. For instance, certain antiepileptic drugs (AEDs) are contraindicated in Dravet Syndrome (DS), which is characterized by a deficiency in Na+ channel ...
Remi Yokoi, Nami Nagafuku, Yuto Ishibashi, Naoki Matsuda, Ikuro Suzuki   +4 more
doaj   +1 more source

Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]

, 2021
ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +1 more source

The Rapid Generation of Cell-Laden, FACS-Compatible Collagen Gels

Organoids, 2023
A three-dimensional cell culture in hydrogel beads can support cell growth and differentiation into multi-cellular structures, and these gel beads could be used as building blocks for more complex three-dimensional assemblies.
Yi Xiao, Qiaoling Huang, Jesse W. Collins, Julie Brouchon, Jeffery A. Nelson, Zachary Niziolek, Alison O’Neil, Fangfu Ye, David A. Weitz, John A. Heyman   +9 more
doaj   +1 more source

A Microwell Device for the Efficient Generation of Arrays of Microtissues and Humanized Bone Marrow Micro-Ossicles

Organoids, 2023
(1) Background: There are no high-throughput microtissue platforms for generating bone marrow micro-ossicles. Herein, we describe a method for the assembly of arrays of microtissues from bone marrow stromal cells (BMSC) in vitro and their maturation into
Kathryn Futrega, Md. Shafiullah Shajib, Pamela G. Robey, Michael R. Doran   +3 more
doaj   +1 more source

Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease

Organoids, 2023
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for infection and ...
Pin Shie Quah, Bang M. Tran, Vincent D.A. Corbin, Jessie J.-Y. Chang, Chinn Yi Wong, Andrés Diaz-Méndez, Carol A. Hartley, Weiguang Zeng, Eric Hanssen, Zlatan Trifunovic, Patrick C. Reading, David C. Jackson, Elizabeth Vincan, Lachlan J.M. Coin, Georgia Deliyannis   +14 more
doaj   +1 more source

Genetic engineering in organoids [PDF]

Journal of Molecular Medicine, 2021
AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom, Andreia S. Batista-Rocha, Bon-Kyoung Koo   +2 more
openaire   +2 more sources

Organoids by design

Science, 2019
Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
openaire   +3 more sources

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Frontiers in Veterinary Science
IntroductionCurrent management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity.
Mengjuan Chen, Mengjuan Chen, Hui Han, Hui Han, Mengke Qin, Mengke Qin, Huixin Li, Huixin Li, Qiqi Lu, Qiqi Lu, Xin Huang, Xin Huang, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +15 more
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The Next Generation of Organoids Will Be More Complex and Even Closer to Resembling Real Organs: An Interview with Prof. Dr. Hans Clevers

Organoids
In this issue, we are pleased and honored to have an interview with Professor Hans Clevers, who is the Advisory Board Member of Organoids [...]
Süleyman Ergün, Organoids Editorial Office   +1 more
doaj   +1 more source