Results 21 to 30 of about 81,677 (304)
Organoids, 2023 Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for infection and ...
Pin Shie Quah +14 more
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Medecine sciences : M/S, 2020 As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé +10 more
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Organoids are not organs: Sources of variation and misinformation in organoid biology
Stem Cell Reports, 2023 In the past decade, the term organoid has moved from obscurity to common use to describe a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of the in vivo organ it models. The term organoid is now applied to structures formed as a result of two distinct processes: the capacity for adult epithelial stem cells ...
Kim Bak Jensen, Melissa Helen Little
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Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
EMBO Molecular Medicine, 2022 Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu +13 more
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Organoids, 2023 The generation of gastrointestinal tissues from human pluripotent stem cells has provided unprecedented insight into the molecular mechanisms that drive the patterning of the primitive gut tube.
Na Qu +3 more
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Science, 2019 Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for ...
Sunghee Estelle Park +2 more
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Vascularizing Organoids to Promote Long-Term Organogenesis on a Chip
Organoids, 2023 Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model.
Xinhui Wang +2 more
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Human Brain Organoids and Consciousness: Moral Claims and Epistemic Uncertainty
Organoids, 2023 Human brain organoids provide a remarkable opportunity to model prenatal human brain biology in vitro by recapitulating features of in utero molecular, cellular and systems biology. An ethical concern peculiar to human brain organoids is whether they are
Eliza Goddard +3 more
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Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACT Over the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Genetic engineering in organoids [PDF]
Journal of Molecular Medicine, 2021 AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom +2 more
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