Results 21 to 30 of about 65,212 (162)

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Journal of Experimental & Clinical Cancer Research
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy ...
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart   +19 more
doaj   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody

Frontiers in Veterinary Science
IntroductionCD3, a surface antigen critical for T cell activation and signal transduction, serves as a key diagnostic marker for T cell-associated malignancies and a therapeutic target in immunotherapy.
Huixin Li, Huixin Li, Mengjuan Chen, Mengjuan Chen, Rongmiao Yue, Rongmiao Yue, Sihao Li, Bowen Shi, Mengke Qin, Mengke Qin, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +13 more
doaj   +1 more source

RNA-sequencing of single cholangiocyte-derived organoids reveals high organoid-to organoid variability

Life Science Alliance, 2022
Over the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised medicine. In recent years, several reports hinted at intraculture organoid variability, but a systematic analysis
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +3 more sources

Air–Liquid-Interface-Differentiated Human Nose Epithelium: The Benchmark Culture Model for SARS-CoV-2 Infection

Organoids
COVID-19 has triggered the rapid adoption of human organoid-based tissue culture models to overcome the limitations of the commonly used Vero cell line that did not fully recapitulate SARS-CoV-2 infection of human tissues. As the primary site of SARS-CoV-
Sarah L. Harbach, Bang M. Tran, Abderrahman Hachani, Samantha Leigh Grimley, Damian F. J. Purcell, Georgia Deliyannis, Joseph Torresi, Julie L. McAuley, Elizabeth Vincan   +8 more
doaj   +1 more source

Pyrvinium Pamoate and BCL-XL Inhibitors Act Synergistically to Kill Patient-Derived Colorectal Adenoma Organoids

Organoids
Current systemic therapies for advanced colorectal cancer (CRC) have limited efficacy, so more effective strategies for the treatment and prevention of CRC are needed.
Maree C. Faux, Chenkai Ma, Serena R. Kane, Andre Samson, Yumiko Hirokawa, Ilka Priebe, Leah Cosgrove, Rajvinder Singh, Michael Christie, Gregor Brown, Kim Y. C. Fung, Antony W. Burgess   +11 more
doaj   +1 more source

Circulating Tumor Cell‐Derived Organoids: Current Progress, Applications, and Future

MedComm – Future Medicine
Circulating tumor cells (CTCs) are malignant cells that detach from primary or metastatic tumors and enter the bloodstream. Organoids, as three‐dimensional in vitro models, can mimic the tumor microenvironment and histopathological characteristics ...
Tiantian Li, Biao Deng, Sheng Li, Yanxia Wu, Zhenghao Lu, Zhu Liang   +5 more
doaj   +1 more source

Mimicking Senescence Factors to Characterize the Mechanisms Responsible for Hair Regression and Hair Loss: An In Vitro Study

Organoids
Background/Objectives: VitroScreenORA® (by VitroScreen srl) Dermo Papilla spheroids, based on two micro-physiological systems (non-vascularized DP and vascularized VASC-DP), were used to study the molecular mechanisms behind hair cycle regression ...
Giacomo Masi, Camilla Guiducci, Francesca Rescigno   +2 more
doaj   +1 more source

Organoid Medicine in Hepatology [PDF]

Clinical Liver Disease, 2020
Answer questions and earn https://www.wileyhealthlearning.com/Activity/7025323/disclaimerspopup.aspx.
Kokoro Sakabe, Takanori Takebe, Akihiro Asai   +2 more
openaire   +2 more sources

Accelerating personalized medicine: miniaturized patient-derived organoid drug screening for predicting cancer treatment responses and beyond

npj Biomedical Innovations
Patient-derived-organoids (PDOs) are valuable tools for predicting individual responses to cancer treatments. However, current screening methods require large numbers of PDOs, resulting in long turnaround times and limiting clinical use. This study aimed
Yasmine Abouleila, Lidwien P. Smabers, Timo Voskuilen, Mayke Doorn, Roel Verkerk, Gakuro Harada, Masahiko Watanabe, Hideaki Kyan, Takahiko Kumagai, Yuichi Hikichi, René Overmeer, Jeanine M. L. Roodhart, Kiyotaka Matsuno, Carla S. Verissimo, Sylvia F. Boj   +14 more
doaj   +1 more source

Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair

Organoids
The stomach epithelium is a highly dynamic tissue that undergoes continuous self-renewal and responds robustly to injury through tightly regulated repair processes. Organoids have emerged as powerful tools for modelling gastrointestinal biology.
Nikki Liddelow, Jie Yu Tan, Dustin J. Flanagan   +2 more
doaj   +1 more source