Results 101 to 110 of about 1,848,273 (305)

For the good of many: an infection control perspective on ethics.

, 2001
The decisions made by infection control personnel affect both individuals and those in the broader patient population in a health care facility. In making the decisions required to provide an environment free of infectious risks, while maintaining the ...
Zimmerman, Peta-Anne
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Profiling the antibody immune response against blood stage malaria vaccine candidates.

, 2007
BACKGROUND: The complexity and diversity of the antibody immune response to the antigen repertoire of a pathogen has long been appreciated. Although it has been recognized that the detection of antibodies against multiple antigens dramatically improves ...
Crisanti, Andrea, Mangia, Elena, Conway, David J, Riley, Eleanor M, Li, Qiuxiang, Holder, Anthony A, Corran, Patrick H, Tetteh, Kevin KA, Bacarese-Hamilton, Tito, Polley, Spencer D, Gaunt, Michael W, Gray, Julian C   +11 more
core   +1 more source

Anaemia in acute HIV-1 subtype C infection. [PDF]

, 2007
BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early ...
Auld, Sara C, van Loggerenberg, Francois, Auld Sara C., Loggerenberg, Francois van, Sobieszczyk Magdalena E., Abdool Karim Salim S., Grobler Anneke, Grobler, Anneke, Anneke Grobler, Auld, Sara C., Itua Iriogbe, Mlisana, Koleka Patience., Iriogbe, Itua, Sobieszczyk, Magdalena E, van Loggerenberg, F, Mlisana, K, Iriogbe, Itua., Salim S Abdool Karim, Mlisana, Koleka, Auld, SC, Abdool Karim, Salim Safurdeen., Sobieszczyk, ME, Grobler, A, Magdalena E Sobieszczyk, Williamson, Carolyn., Carolyn Williamson, Francois van Loggerenberg, Abdool Karim, Salim S, Sobieszczyk, Magdalena E., Iriogbe, I, Williamson Carolyn, Abdool Karim, SS, Sara C Auld, Team, for the CAPRISA Acute Infection Study, Williamson, Carolyn, Williamson, C, Grobler, Anna Christina., van Loggerenberg, Francois., van Loggerenberg Francois, Karim, Salim S Abdool, Koleka Mlisana, Iriogbe Itua, Mlisana Koleka, CAPRISA Acute Infection Study Team   +43 more
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Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

Respiratory Research, 2009
Background Highly pathogenic avian influenza (HPAI) H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death.
Yuen Kit M, Lo CK, Chui WH, Ho Carol CC, Yu Wendy CL, Chan Renee WY, Chan Michael CW, Guan Yi, Nicholls John M, Peiris JS Malik   +9 more
doaj   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Refractory apical periodontitis associated with a calculus-like deposit at the root apex

Journal of Dental Sciences, 2010
In this case report, we describe a refractory case in which a calculus-like deposit was found at the apical root surfaces of two adjacent teeth. This case involved a 45-year-old male with a sinus tract at the labial mucosa of the maxillary left central ...
Cheng-Mei Yang, Yao-Dung Hsieh, Shue-Fen Yang   +2 more
doaj   +1 more source

Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism.
Drew, Damien R., Anders, Robin, Sheetij Dutta, Cross, Nadia, Senn, Nicolas, Hodder, AN, Dutta, Sheetij, Nicolas Senn, Osier, Faith H. A., Terheggen, Ulrich, Hodder, Anthony, Damien R Drew, Beeson, JG, Nadia J Cross, James G Beeson, Mugyenyi, Cleopatra, Osier, FHA, Alyssa E Barry, Ulrich Terheggen, Hodder, Anthony N., Barry, Alyssa, Siba, Peter, Mueller, I, Siba, PM, Beeson, James, Drew, DR, Stanisic, Danielle I., Terheggen, U, Anders, RF, Beeson, James G., Peter M Siba, Dutta, S, Cross, Nadia J., Stanisic, Danielle, Kevin Marsh, Faith HA Osier, Elliott, Salenna, Barry, AE, Jack S Richards, Anders, Robin F., Barry, Alyssa E., Elliott, Salenna R., Senn, N, Danielle I Stanisic, Stanisic, DI, Mueller, Ivo, Richards, Jack, Ivo Mueller, Marsh, K, Elliott, SR, Richards, Jack S., Drew, Damien, Anthony N Hodder, Mugyenyi, Cleopatra K., Cleopatra K Mugyenyi, Osier, Faith, Richards, JS, Robin F Anders, Cross, NJ, Salenna R Elliott, Marsh, Kevin, Mugyenyi, CK, Siba, Peter M.   +62 more
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TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source