Results 61 to 70 of about 1,848,273 (305)
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
AntibioticsBackground: Pulpitis requires operative dental treatment, and antibiotics are not indicated. Nevertheless, inappropriate antibiotic prescribing persists worldwide.
Vanessa Delgado-Giugni +7 more
doaj +1 more source
Root Microbiota in Primary and Secondary Apical Periodontitis
Frontiers in Microbiology, 2018 Apical periodontitis is an inflammatory disease of the dental periradicular tissues triggered by bacteria colonizing necrotic root canals. Primary apical periodontitis results from the microbial colonization of necrotic pulp tissues.
Serge Bouillaguet +7 more
doaj +1 more source
A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]
, 2014 The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B. +4 more
core +1 more source
Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions
Advanced Science, EarlyView.Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han +11 more
wiley +1 more source
Pyrosequencing analysis of apical microbiota of teeth with persistent apical periodontitis
Journal of Dental Sciences, 2015 Background/purpose: Bacteria inside and outside the root canal at the apical area are crucial for persistent periapical infection. Thus, we aimed to investigate the composition and diversity of apical microbiota in persistent apical periodontitis lesions.
Yifan Ping, Juan Wang, Jingping Liang
doaj +1 more source
Gut Microbes, 2021 Salmonella pathogenicity island (SPI) 2 type three secretion system (T3SS)-mediated effector molecules facilitate bacterial survival in phagocytes but their role in the intestinal epithelium in vivo remains ill-defined.
Marcus Fulde +17 more
doaj +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
AntibioticsAfter pulp infection and necrosis, the passage of microbial antigens into the periapical space causes apical periodontitis (AP). Most of the clinical forms of AP can be managed without prescribing antibiotics, only with root canal treatment and abscess ...
Juan A. Méndez-Millán +5 more
doaj +1 more source
Frontiers in Veterinary Science, 2018 BackgroundEquine cheek teeth disorders, especially pulpar/apical infections, can have very serious consequences due to the frequent extension of infection to the supporting bones and/or adjacent paranasal sinuses.
Tiziana Liuti +2 more
doaj +1 more source