Results 41 to 50 of about 17,951 (220)

Meat-Borne-Parasite: A Nanopore-Based Meta-Barcoding Work-Flow for Parasitic Microbiodiversity Assessment in the Wild Fauna of French Guiana

Current Issues in Molecular Biology
French Guiana, located in the Guiana Shield, is a natural reservoir for many zoonotic pathogens that are of considerable medical or veterinary importance.
Adria Matoute, Simone Maestri, Mona Saout, Laure Laghoe, Stéphane Simon, Hélène Blanquart, Miguel Angel Hernandez Martinez, Magalie Pierre Demar   +7 more
doaj   +1 more source

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Repurposing of conserved autophagy-related protein ATG8 in a divergent eukaryote

Communicative & Integrative Biology, 2016
Toxoplasma gondii and other apicomplexan parasites contain a peculiar non-photosynthetic plastid called the apicoplast, which is essential for their survival.
Maude F. Lévêque, Hoa Mai Nguyen, Sébastien Besteiro   +2 more
doaj   +1 more source

Sexual Development in Non-Human Parasitic Apicomplexa: Just Biology or Targets for Control?

Animals, 2021
The phylum Apicomplexa is a major group of protozoan parasites including gregarines, coccidia, haemogregarines, haemosporidia and piroplasms, with more than 6000 named species. Three of these subgroups, the coccidia, hemosporidia, and piroplasms, contain
Teresa Cruz-Bustos, Anna Sophia Feix, Bärbel Ruttkowski, Anja Joachim   +3 more
doaj   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Clinical, laboratory and epidemiological aspects of Cryptosporidium parvum and Cryptosporidium hominis infection: a integrative review [PDF]

Brazilian Journal of Biology
Cryptosporidium parvum and Cryptosporidium hominis infection causes cryptosporidiosis, which in humans can result in watery diarrhea that is usually self-limited in immunocompetent individuals, but can be chronic and fatal in immunocompromised ...
R. L. M. Mendonça, M. S. Miranda, A. C. Guimarães, A. P. Queiroga, H. F. M. Câmara, P. H. L. T. S. Anjos, J. V. Ferro, H. B. G. Messias, T. L. G. Q. Maranhão, A. C. S. Omena, A. C. Silva, C. J. Santos Júnior, B. C. Omena, M. G. S. Cavalcanti, T. J. M. Rocha, G. C. Ferreira Júnior   +15 more
doaj   +1 more source

Droplet digital PCR as a tool for investigating dynamics of cryptic symbionts

Ecology and Evolution, 2021
Interactions among symbiotic organisms and their hosts are major drivers of ecological and evolutionary processes. Monitoring the infection patterns among natural populations and identifying factors affecting these interactions are critical for ...
Anna‐Lotta Hiillos, Anne Thonig, Karelyn Emily Knott   +2 more
doaj   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source