Results 111 to 120 of about 340,068 (318)

Alternative donor transplants for severe aplastic anemia.

Hematology. American Society of Hematology. Education Program, 2018
Allogeneic hematopoietic stem-cell transplantation remains the only curative treatment for patients with acquired severe aplastic anemia (SAA). When a matched sibling is not available, one can search for a matched unrelated donor or a cord blood unit (CB)
A. Bacigalupo
semanticscholar   +1 more source

Never say never

Journal of Hospital Medicine, EarlyView.
Gurpreet Dhaliwal, Jagmeet Dhingra, Tom Fraser, Leal Herlitz, James Pile   +4 more
wiley   +1 more source

Real‐world clinical experience with NGS‐based chimerism analyses in haematopoietic stem cell transplant patients

British Journal of Haematology, EarlyView.
This study demonstrates the clinical utility of a next‐generation sequencing (NGS)‐based chimerism assay (CASAL) in haematopoietic stem cell transplantation (HSCT). Compared to conventional short tandem repeat (STR) methods, CASAL showed significantly higher marker informativeness, detecting mixed chimerism (MC) below 5% recipient DNA with a median of ...
Jin Ju Kim, Soon Sung Kwon, Yu Jeong Choi, Yehyun Kang, Yu Jin Park, Saeam Shin, Seung‐Tae Lee, Jong Rak Choi   +7 more
wiley   +1 more source

Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group

Haematologica, 2011
Background Although the therapeutic outcome of acquired aplastic anemia has improved markedly with the introduction of immunosuppressive therapy using antithymocyte globulin and cyclosporine, a significant proportion of patients subsequently relapse and ...
Takuya Kamio, Etsuro Ito, Akira Ohara, Yoshiyuki Kosaka, Masahiro Tsuchida, Hiroshi Yagasaki, Hideo Mugishima, Hiromasa Yabe, Akira Morimoto, Shouichi Ohga, Hideki Muramatsu, Asahito Hama, Takashi Kaneko, Masayuki Nagasawa, Atsushi Kikuta, Yuko Osugi, Fumio Bessho, Tatsutoshi Nakahata, Ichiro Tsukimoto, Seiji Kojima   +19 more
doaj   +1 more source

Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

Journal of Hematology & Oncology, 2017
BackgroundHaploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refractory to immunosuppressive therapy ...
Lanping Xu, S. Jin, Shunqing Wang, L. Xia, H. Bai, Sujun Gao, Qi-fa Liu, Jian-min Wang, Xin Wang, M. Jiang, Xi Zhang, Depei Wu, Xiao-jun Huang   +12 more
semanticscholar   +1 more source

Romiplostim with ciclosporin A in patients with aplastic anaemia naïve to immunosuppressive therapy: A phase 2/3 study

British Journal of Haematology, EarlyView.
This phase 2/3 study evaluated romiplostim plus ciclosporin A as first‐line treatment for patients with aplastic anaemia naïve to immunosuppressive therapy. The combination demonstrated a promising overall response rate at 27 weeks, with improvements in blood counts across multiple lineages and reduced transfusion requirements.
Jong Wook Lee, Jun Ho Jang, Shigeru Chiba, Sung‐Soo Yoon, Gaku Oshikawa, Kensuke Usuki, Yeung‐Chul Mun, Toshiro Kawakita, Kazunori Imada, June‐Won Cheong, Masayoshi Noshiro, Akira Matsuda, Keiya Ozawa, Kinuko Mitani, Yoshinobu Kanda, Shinji Nakao   +15 more
wiley   +1 more source

Current strategies against invasive fungal infections in patients with aplastic anemia, strong power and weak weapon, a case report and review of literature

Medical Mycology Case Reports, 2016
We report an 18 year old boy with Aplastic anemia complicated by serious fungal rhinosinusitis. Despite prompt treatment and early repeated surgical debridements, he died after about more than 6 weeks of hard challenges with fungal infections.
Omid Reza Zekavat, Ali Amanati, Fazl Saleh, Babak Abdolkarimi, Gholamreza Fathpour, Parisa Badiee, Bita Geramizadeh   +6 more
doaj   +1 more source

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

Haematologica, 2018
Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several solid and hematologic malignancies.
V. Giudice, L. Banaszak, Fernanda Gutierrez-Rodrigues, S. Kajigaya, Reema Panjwani, Mariam Ibanez, O. Rios, Christopher K. E. Bleck, E. Stempinski, Diego Raffo, D. Townsley, N. Young   +11 more
semanticscholar   +1 more source

Efficacy and safety of HRS‐5965 monotherapy in complement inhibitor–naïve patients with paroxysmal nocturnal haemoglobinuria

British Journal of Haematology, EarlyView.
Summary Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, life‐threatening disorder characterized by complement‐mediated haemolysis, leading to anaemia and thrombosis. HRS‐5965 is a novel, oral, selective complement factor B inhibitor targeting the alternative pathway, potentially reducing both intra‐ and extravascular haemolysis.
Li Zhang, Ziwei Liu, Xin Zhao, Bin Hu, Rong Huang, Chang Shu, Fengkui Zhang, Bing Han   +7 more
wiley   +1 more source

Adding eltrombopag to immunosuppression: the importance of predicting outcome

Haematologica, 2021
André Tichelli, Régis Peffault de Latour, Carlo Dufour, Alicia Rovó   +3 more
doaj   +1 more source