Results 1 to 10 of about 334,526 (159)

APLASTIC ANEMIA [PDF]

Vnitřní lékařství, 2018
Aplastic anemia is an historic disease. The first patient was described by the young Paul Ehrlich in 1885, “anemia aplastique” originated with Vaquez in 1904, and its clinical features were described by Cabot and other pathologists in the early 20 th ...
N. S. Young
semanticscholar   +6 more sources

Pathogenesis of aplastic anemia [PDF]

Hematology, 2019
Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation.
Li Wang, Hong Liu
semanticscholar   +3 more sources

Epidemiology of aplastic anemia: a study of 1324 cases

Hematology, 2020
Objective: Prevalence of aplastic anemia (AA) is high in the Asian population. This study was done to explore the etiology and association of AA with various socio-economic and environmental factors.
Iftikhar R, Qamar Un Nisa Chaudhry, Zaineb Akram   +2 more
exaly   +2 more sources

Hepatitis-associated aplastic anemia.

Hematology/Oncology and Stem Cell Therapy, 2020
Hepatitis-associated aplastic anemia (HAAA) is a rare illness, characterized by onset of pancytopenia with a hypoplastic bone marrow that traditionally occurs within 6 months of an increase in serum aminotransferases.
Alfadel Alshaibani, C. Dufour, A. Risitano, R. D. de Latour, M. Aljurf   +4 more
semanticscholar   +5 more sources

Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

Haematologica, 2018
Oligoclonal expansion of CD8+ CD28− lymphocytes has been considered indirect evidence for a pathogenic immune response in acquired aplastic anemia. A subset of CD8+ CD28− cells with CD57 expression, termed effector memory cells, is expanded in several ...
Valentina Giudice, Xingmin Feng, Zenghua Lin, Wei Hu, Fanmao Zhang, Wangmin Qiao, Maria del Pilar Fernandez Ibanez, Olga Rios, Neal S. Young   +8 more
doaj   +2 more sources

Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Journal of Clinical Oncology, 2022
PURPOSE Secondary myeloid neoplasms (sMNs) remain the most serious long-term complications in patients with aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH).
C. Gurnari, S. Pagliuca, P. Prata, J. Galimard, L. F. B. Catto, L. Larcher, M. Sébert, V. Allain, B. Patel, Arda Durmaz, A. Pinto, M. C. B. Inacio, L. Hernandez, N. Dhédin, S. Caillat-Zucman, E. Clappier, F. Sicre de Fontbrune, M. Voso, V. Visconte, Régis Peffault de Latour, J. Soulier, R. Calado, G. Socié, J. Maciejewski   +23 more
semanticscholar   +1 more source

A RARE CASE REPORT OF SUBDURAL HAEMATOMA WITH ANEMIA APLASTIC

, 2021
Objective and Importance. To illustrate the development of a rare case of spontaneous subdural hematoma (SDH)  secondary to aplastic anemia and conservative treatment of SDH. Clinical Presentation.
F. Makkiyah, Rahma Hida Nurrizka
semanticscholar   +1 more source

Efficacy of combined immunosuppression with or without eltrombopag in children with newly diagnosed aplastic anemia

Blood Advances, 2022
Key Points • Eltrombopag combined with standard IST increased the complete response rate in treatment-naïve children with severe aplastic anemia.• Eltrombopag combined with IST increased the overall response rate in pediatric patients with SAA but not in
O. Goronkova, G. Novichkova, T. Salimova, I. Kalinina, D. Baidildina, U. Petrova, K. Antonova, M. Sadovskaya, E. Suntsova, D. Evseev, V. Matveev, D. Venyov, L. Khachatryan, D. Litvinov, A. Pshonkin, G. Ovsyannikova, N. Kotskaya, D. Gobadze, Y. Olshanskaya, A. Popov, E. Raykina, O. Mironenko, K. Voronin, B. Purbueva, E. Boichenko, Y. Dinikina, E. Guseynova, Dmitry G. Sherstnev, E. Kalinina, S. Mezentsev, O. Streneva, N. Yudina, O. Plaksina, E. Erega, M. Maschan, A. Maschan   +35 more
semanticscholar   +1 more source

Experiences and Support Needs of Caregivers of Patients with Higher-Risk Myelodysplastic Syndrome via Online Bulletin Board in the USA, Canada and UK

Oncology and Therapy, 2023
Introduction Patients with higher-risk myelodysplastic syndromes (MDS) face considerable challenges in disease management and often require caregiver support.
Pauline Frank, Anne Olshan, Tracey Iraca, Cindy Anthony, Sophie Wintrich, Emma Sasse   +5 more
doaj   +1 more source

JAK-inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia

i Medicina, 2022
Summary Background: Idiopathic aplastic anemia is a potentially lethal disease, characterized by T-cell mediated autoimmune attack of bone marrow hematopoietic stem cells.
Jacob M. Rosenberg, Joshua M. Peters, T. Hughes, C. Lareau, Leif S. Ludwig, Lucas R. Massoth, C. Austin-Tse, H. Rehm, Bryan D. Bryson, Yi-Bin Chen, A. Regev, A. Shalek, S. Fortune, D. Sykes   +13 more
semanticscholar   +1 more source