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Genomic landscape of immune checkpoint inhibitor-induced aplastic anemia: a case report [PDF]
Frontiers in OncologyHematological immune-related adverse events caused by immunotherapy are relatively uncommon. Aplastic anemia triggered by immune checkpoint inhibition is rare and its genomic characteristic remains largely unexplored. This case report describes a 42-year-
Nobuyuki Takahashi +24 more
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Pathogenesis of aplastic anemia [PDF]
Hematology, 2019 Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated.
Hong Liu
exaly +3 more sources
Oncology and Therapy, 2023 Introduction Patients with higher-risk myelodysplastic syndromes (MDS) face considerable challenges in disease management and often require caregiver support.
Pauline Frank +5 more
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Vnitřní lékařství, 2018 Aplastic anemia - bone marrow failure (AA) is defined as pancytopenia with hypocellular bone marrow without signs of marrow fibrosis or of presence of abnormal cells. Recent studies showed that most of AA cases might be mediated by immune mechanisms.
openaire +5 more sources
Current Opinion in Internal Medicine, 2008 Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation.In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of ...
Neal S, Young +2 more
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Aplastic Anemia Treated with Eltrombopag during Pregnancy
Case Reports in Obstetrics and Gynecology, 2022 Aplastic anemia is a rare blood disorder characterized by pancytopenia and hypocellular bone marrow. In patients with aplastic anemia, pancytopenia sometimes worsens during pregnancy, and relapse of aplastic anemia in pregnancy is common.
Yuri Suminaga +7 more
doaj +1 more source
Archives of Anesthesia and Critical Care, 2022 Aplastic anemia is rare hematological disorder with approximate incidence 1.5-7 cases per million individuals per year. Osteonecrosis, a frequently seen in patients with aplastic anemia.
Shalvi Mahajan +3 more
doaj +1 more source
Cell Transplantation, 2021 The present study aimed to investigate the effect and possible mechanism of recombinant human thrombopoietin (rhTPO) on mouse 32D cells (a mouse myeloid progenitor cell line) treated with serum from patients with aplastic anemia and to elucidate the ...
Juan Qian +7 more
doaj +1 more source
Aplastic anemia in China [PDF]
Journal of Translational Internal Medicine, 2018 Abstract Aplastic anemia (AA) is a hematologic disease characterized by pancytopenia. Up to now, severe aplastic anemia (SAA) has been recognized by international and domestic scholars as an autoimmune disease with bone marrow (BM) failure mediated by the hyperfunctional T lymphocytes.
Liu, Chunyan, Shao, Zonghong
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Profil Penderita Anemia Aplastik di RSUP Dr. M. Djamil Padang Tahun 2018-2019
Jurnal Ilmu Kesehatan Indonesia, 2021 Background. Aplastic anemia is a failure of the process of formation and development of blood cells that causes a decrease or absence of hematopoietic precursor cells in the bone marrow.
Amanda Rizki +2 more
doaj +1 more source