Results 31 to 40 of about 24,700 (204)

Thymoma followed by aplastic anemia: two different responses to immunosuppressive therapy

Revista Brasileira de Hematologia e Hemoterapia, 2011
Aplastic anemia is an uncommon complication of thymoma and is extremely infrequent after the surgical removal of a thymic tumor. Aplastic anemia is a result of marrow failure and is characterized by peripheral pancytopenia and severely depressed marrow ...
Murilo Antunes de Castro, Mariana Antunes de Castro, Adriano de Moraes Arantes, Maria do Rosário Ferraz Roberti   +3 more
doaj   +1 more source

Management of Aplastic Anemia in Pregnancy: A Case Report

Indonesian Journal of Obstetrics and Gynecology, 2020
Aplastic anemia was first recognized by Ehrlich in 1888, although the pathogenesis of aplastic anemia has remained elusive. Aplastic anemia is a subtype of anemia characterized by pancytopenia and a hypocellular bone marrow which are the risk factor can ...
Suskhan Djusad, Yoarva Malano
doaj   +1 more source

Syngeneic peripheral blood stem cell transplantation with immunosuppression for hepatitis-associated severe aplastic anemia

Turkish Journal of Hematology, 2010
Hepatitis-associated aplastic anemia occurs in up to 10% of all aplastic anemia cases. Syngeneic bone marrow transplantation is rare in patients with severe aplastic anemia and usually requires pre-transplant conditioning to provide engraftment.
Aleksandar Savic, Bela Balint, Ivana Urosevic, Nebojsa Rajic, Milena Todorovic, Ivanka Percic, Stevan Popovic   +6 more
doaj   +3 more sources

Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation

Haematologica, 2014
A proportion of patients with aplastic anemia who are treated with immunosuppressive therapy develop clonal hematologic disorders, including post-aplastic anemia myelodysplastic syndrome.
Sung-Yong Kim, Jennifer Le Rademacher, Joseph H. Antin, Paolo Anderlini, Mouhab Ayas, Minoo Battiwalla, Jeanette Carreras, Joanne Kurtzberg, Ryotaro Nakamura, Mary Eapen, H. Joachim Deeg   +10 more
doaj   +1 more source

Effectiveness of Iptacopan Versus C5 Inhibitors in Complement Inhibitor‐Naive Patients With Paroxysmal Nocturnal Haemoglobinuria

eJHaem
Background Paroxysmal nocturnal haemoglobinuria (PNH) is characterised by haemolytic anaemia, bone marrow failure and thrombosis. The single‐arm phase 3 APPOINT‐PNH trial (NCT04820530) investigating iptacopan monotherapy in complement inhibitor‐naive ...
Matthew Holt, Richard J. Kelly, Jilles M. Fermont, Soudeh Ansari, Marion Dahlke, Isabelle Brindel, Lynda Maafa, Flore Sicre deFontbrune, Régis Peffault deLatour   +8 more
doaj   +1 more source

CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL

Haematologica, 2012
Background Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34+ stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem ...
Ute Fischer, Christian Ruckert, Bernd Hubner, Olaf Eckermann, Vera Binder, Tamam Bakchoul, Friedhelm R. Schuster, Sylvia Merk, Hans-Ulrich Klein, Monika Führer, Martin Dugas, Arndt Borkhardt   +11 more
doaj   +1 more source

Eltrombopag in Aplastic Anemia [PDF]

Seminars in Hematology, 2015
The treatment of aplastic anemia is currently with immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG) and cyclosporine, to which two thirds of patients respond. However, a significant proportion of these responders relapse and many have persistent cytopenias. The management of these patients is challenging.
Ronan, Desmond, Danielle M, Townsley, Cynthia, Dunbar, Neal S, Young   +3 more
openaire   +2 more sources

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

THPO gene variants in patients with acquired aplastic anemia

Hematology, Transfusion and Cell Therapy, 2018
Background: Human aplastic anemia is a hematologic disease characterized by low peripheral blood cell counts associated with reduced numbers of hematopoietic stem and progenitor cells and a hypocellular bone marrow.
Pedro Henrique Padilha, Gustavo Borges, Barbara Amélia Santana, Larissa Alessandra Medeiros, Samir Kanaan Nabhan, Ricardo Pasquini, Flavia Sacilotto Donaires, Rodrigo Tocantins Calado   +7 more
doaj   +1 more source

Hepatitis-associated aplastic anemia from workout supplement: Rare but potentially fatal entity

SAGE Open Medical Case Reports, 2020
Hepatitis-associated aplastic anemia (HAAA) is a rare clinical syndrome characterized by bone marrow failure 1–3 months after development of hepatitis. Untreated, hepatitis-associated aplastic anemia has poor outcome and the mainstay of treatment remains
Sanjog Bastola, Ojbindra Kc, Sumesh Khanal, Alexandra Halalau   +3 more
doaj   +1 more source