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Aplastic anemia: Pathophysiology
Seminars in Hematology, 2022Bone marrow failure (BMF) syndromes are a heterogeneous group of benign hematological conditions characterized by uni- or multi-lineage marrow and/or peripheral blood cytopenia(s), and can be classified in constitutional or acquired syndromes based on pathophysiology.
Giudice V., Selleri C.
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Erythropoietin in aplastic anemia
Blut, 1979The level of erythropoietin (Ep) was measured in sera and urine from aplastic anemia patients. Increased levels of Ep were demonstrated in sera from all 25 patients studied. An elevated level of Ep was found in the urine of 17 of 23 patients in whom the urine was tested. No correlation between blood hemoglobin and Ep level was observed.
V, Pavlovic-Kentera +4 more
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Aplastic and Hypoplastic Anemias
Pediatrics In Review, 20181. Suzie A. Noronha, MD* 1. *Division of Pediatric Hematology/Oncology, University of Rochester, Rochester, NY * Abbreviations: AA: : aplastic anemia AML: : acute myeloid leukemia ANC: : absolute neutrophil count ARC: : absolute reticulocyte count CBC: : complete blood cell DBA ...
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Hematology/Oncology Clinics of North America, 1990
Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
T P, Loughran, R, Storb
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Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
T P, Loughran, R, Storb
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JAMA: The Journal of the American Medical Association, 1982
To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
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To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
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Methylprednisolone and Aplastic Anemia
Annals of Internal Medicine, 1985Excerpt To the editor: Over the past decade, clinical and laboratory evidence has suggested that aplastic anemia is, in some patients, due to an "autoimmune mechanism," and interest has focused on ...
S, Issaragrisil, A, Painkijagum
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Insecticides and Aplastic Anemia
New England Journal of Medicine, 1963TO prove that a drug or chemical has an etiologic relation to aplastic anemia is a difficult task. This is due mainly to the low incidence with which their use is followed by the disease, making it necessary to accumulate a sizable number of suspicious cases to find a statistical argument in its favor.
L, SANCHEZ MEDAL +2 more
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Annals of Internal Medicine, 1999
In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes.
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In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes.
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International Journal of Hematology, 2002
Aplastic anemia (AA) is more common in Asia than in Europe or the United States. This may be due in part to the high incidence of hepatitis-associated AA in Asia. The management of AA has evolved rapidly in Japan during the last decade. Advances in the treatment of AA have largely been the result of prospective collaborative studies of ...
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Aplastic anemia (AA) is more common in Asia than in Europe or the United States. This may be due in part to the high incidence of hepatitis-associated AA in Asia. The management of AA has evolved rapidly in Japan during the last decade. Advances in the treatment of AA have largely been the result of prospective collaborative studies of ...
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Aplastic Anemia and Splenectomy
Archives of Internal Medicine, 1967THE GRAVE prognosis associated with aplastic anemia is well established and has been repeatedly documented.1-3Various regimens have been explored in the management of this disease. These include either alone or in combinations, adrenocorticosteroids, androgens, and splenectomy.2,4 6Varying degrees of success have been reported and a number of ...
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