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Aplastic and Hypoplastic Anemia
Pediatric Clinics of North America, 1980Aplastic anemia is an acquired or constitutional trilineage bone marrow failure with peripheral pancytopenia, evidence of cellular hypoplasia of marrow, and replacement of normal cellular elements by fat. In some cases the marrow may be hypoplastic and the peripheral cytopenia relatively mild.
David G. Nathan, Jeffrey M. Lipton
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Annals of Internal Medicine, 1999
In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes.
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In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes.
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JAAPA : official journal of the American Academy of Physician Assistants
Aplastic anemia (AA) is an inherited, idiopathic, or acquired syndrome of bone marrow failure characterized by pancytopenia and ineffective hematopoiesis.
Alexis C. Geppner
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Aplastic anemia (AA) is an inherited, idiopathic, or acquired syndrome of bone marrow failure characterized by pancytopenia and ineffective hematopoiesis.
Alexis C. Geppner
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Erythropoietin in aplastic anemia
Blut, 1979The level of erythropoietin (Ep) was measured in sera and urine from aplastic anemia patients. Increased levels of Ep were demonstrated in sera from all 25 patients studied. An elevated level of Ep was found in the urine of 17 of 23 patients in whom the urine was tested. No correlation between blood hemoglobin and Ep level was observed.
L Biljanovic-Paunovic +4 more
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JAMA: The Journal of the American Medical Association, 1982
To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
Frederick T. Fraunfelder +1 more
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To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
Frederick T. Fraunfelder +1 more
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Current Concepts of the Pathogenesis of Aplastic Anemia.
Current pharmaceutical design, 2019Abnormal activation of the immune system plays an important role in the pathogenesis of aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune network, leading to bone marrow failure. The known pathogenesis is an increase of
Chunyan Liu, Yingying Sun, Z. Shao
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Management of aplastic anemia after failure of frontline immunosuppression
Expert Review of Hematology, 2019Introduction: About 60% of aplastic anemia (AA) patients are in need of further treatment after frontline standard immunosuppressive therapy (IST).
F. Pierri, C. Dufour
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Hematology/Oncology Clinics of North America, 1990
Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
Thomas P. Loughran, Rainer Storb
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Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
Thomas P. Loughran, Rainer Storb
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The Journal of Nervous and Mental Disease, 1984
A 29-year-old married nurse with pancytopenia was discovered to be surreptitiously ingesting alkylating agents. Despite her life-threatening behavior, there was no evidence that she was psychotic, depressed, or cognitively impaired. Psychological testing was indicative of a sociopathic personality.
Mark P. Kelly +3 more
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A 29-year-old married nurse with pancytopenia was discovered to be surreptitiously ingesting alkylating agents. Despite her life-threatening behavior, there was no evidence that she was psychotic, depressed, or cognitively impaired. Psychological testing was indicative of a sociopathic personality.
Mark P. Kelly +3 more
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Methylprednisolone and Aplastic Anemia
Annals of Internal Medicine, 1985Excerpt To the editor: Over the past decade, clinical and laboratory evidence has suggested that aplastic anemia is, in some patients, due to an "autoimmune mechanism," and interest has focused on ...
Anong Painkijagum, Surapol Issaragrisil
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