Results 291 to 300 of about 340,068 (318)
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Current Concepts of the Pathogenesis of Aplastic Anemia.
Current pharmaceutical design, 2019Abnormal activation of the immune system plays an important role in the pathogenesis of aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune network, leading to bone marrow failure. The known pathogenesis is an increase of
Chunyan Liu, Yingying Sun, Z. Shao
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JAMA: The Journal of the American Medical Association, 1982
To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
Frederick T. Fraunfelder +1 more
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To the Editor.— Two cases of fatal aplastic anemia following the use of topical ocular chloramphenicol have been recently reported. 1,2 Regardless of dosage, systemic chloramphenicol can cause an idiosyncratic, usually fatal, hemopoietic event, with an incidence rate of one in 30,000 to 50,000 patients. This incidence is 13 times greater than the risk
Frederick T. Fraunfelder +1 more
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Hematology/Oncology Clinics of North America, 1990
Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
Thomas P. Loughran, Rainer Storb
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Survival of patients with aplastic anemia after immunosuppressive therapy with ATG/ALG ranges from 35% to 60%. However, long-term follow-up on these patients has indicated a high frequency of hematologic complications, including PNH, myelodysplasia, ANL, and recurrent aplasia.
Thomas P. Loughran, Rainer Storb
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The Journal of Nervous and Mental Disease, 1984
A 29-year-old married nurse with pancytopenia was discovered to be surreptitiously ingesting alkylating agents. Despite her life-threatening behavior, there was no evidence that she was psychotic, depressed, or cognitively impaired. Psychological testing was indicative of a sociopathic personality.
Mark P. Kelly +3 more
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A 29-year-old married nurse with pancytopenia was discovered to be surreptitiously ingesting alkylating agents. Despite her life-threatening behavior, there was no evidence that she was psychotic, depressed, or cognitively impaired. Psychological testing was indicative of a sociopathic personality.
Mark P. Kelly +3 more
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Methylprednisolone and Aplastic Anemia
Annals of Internal Medicine, 1985Excerpt To the editor: Over the past decade, clinical and laboratory evidence has suggested that aplastic anemia is, in some patients, due to an "autoimmune mechanism," and interest has focused on ...
Anong Painkijagum, Surapol Issaragrisil
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Insecticides and Aplastic Anemia
New England Journal of Medicine, 1963TO prove that a drug or chemical has an etiologic relation to aplastic anemia is a difficult task. This is due mainly to the low incidence with which their use is followed by the disease, making it necessary to accumulate a sizable number of suspicious cases to find a statistical argument in its favor.
F. García-Rojas +2 more
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Cyclophosphamide in aplastic anemia? [PDF]
Blood, 2010 The use of high-dose cyclophosphamide without stem cell support has been proposed by physicians at John Hopkins University Hospital for many years as treatment for patients with newly diagnosed or refractory aplastic anemia. In this issue of Blood, Brodsky and colleagues report the long-term follow-up of their single-center clinical trial.
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Aplastic anemia or aplastic preleukemic syndrome?
Annals of Hematology, 1997The incidence of aplastic anemia appears to be relatively high in some parts of the world, including Pakistan. Since some of the etiological factors are shared by aplastic anemia and the preleukemic syndrome, there is a strong possibility that a proportion of cases of aplastic anemia may in fact be preleukemia.
P. A. Ahmad +5 more
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Aplastic and Hypoplastic Anemias
Pediatrics In Review, 20181. Suzie A. Noronha, MD* 1. *Division of Pediatric Hematology/Oncology, University of Rochester, Rochester, NY * Abbreviations: AA: : aplastic anemia AML: : acute myeloid leukemia ANC: : absolute neutrophil count ARC: : absolute reticulocyte count CBC: : complete blood cell DBA ...
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Aplastic Anemia and Splenectomy
Archives of Internal Medicine, 1967THE GRAVE prognosis associated with aplastic anemia is well established and has been repeatedly documented.1-3Various regimens have been explored in the management of this disease. These include either alone or in combinations, adrenocorticosteroids, androgens, and splenectomy.2,4 6Varying degrees of success have been reported and a number of ...
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