Results 81 to 90 of about 174,900 (290)

Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]

, 2018
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat, Brown, Jesse A, Fredericks, Carolyn A, Hua, Alice Y, Resnick, Susan M, Seeley, William W, Sturm, Virginia E, Wong, Dean F   +7 more
core   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Genetic predictors of the effectiveness of the standard low-calorie diet in obese patients

Ожирение и метаболизм, 2016
Objectives: The aim of the study was to investigate the genetic predictors of standard low-calorie diet at different polymorphic variations ApoE and LPL genes in obese patients.Materials and methods: Our study involved 88 obese patients aged 19 to 67 ...
Tatyana Sentsova, Olga Chernyak, Ilya Vorozhko, Kamila Gapparova, Olga Grigoryan, Yulya Chekhonina, Alexandra Churycheva   +6 more
doaj   +1 more source

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

''Η ηθικοπολιτική ύπαρξη των Μ.Κ.Ο.''

, 2022
Στην παρούσα έρευνα θα επιχειρήσουμε, με σημείο εκκίνησης την ιστορική αναδρομή στη σύσταση των Μη Κυβερνητικών Οργανώσεων, να θέσουμε ως αντικείμενο συζήτησης τη φιλοσοφική αντίληψη του ωφελιμισμού και της πρακτικής της εφαρμογής στις ΜΚΟ. Έτσι, αρχής γενομένης από την ανάλυση του τρόπου και των βασικών αρχών μέσω των οποίων οι εν λόγω οργανώσεις ...
openaire   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]

, 2005
We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Andreasen N, Annica Johansson, Blennow K, Braak E, Bybee A, Donovan N, Dranovsky A, Evan G, Farrer LA, Feilotter H, Georgi AB, Giovanni A, Grana X, Harald Hampel, Hardy J, Henrik Zetterberg, Husseman JW, Hyman AA, Johansson A, Jonathan A. Prince, Jordan-Sciutto K, Kaj Blennow, Katharina Buerger, Kitamura Y, Kobayashi S, Konishi Y, Lars-Olof Wahlund, Ledesma MD, Lennart Minthon, Lindwall G, Liu DX, McKhann G, Meyer JM, Mirra SS, Nagy Z, Pei JJ, Simpson NE, Strittmatter WJ, Suzuki T, Vanderstichele H, Vincent I, Vulliet R, Zhang J   +42 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Genetic Risk for Alzheimer\u27s Disease Alters the Five-Year Trajectory of Semantic Memory Activation in Cognitively Intact Elders [PDF]

, 2015
Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts.
Bonner-Jackson, Aaron, Durgerian, Sally, Nielson, Kristy A, Rao, Stephen M., Seidenberg, Michael, Smith, J. Carson, Woodard, John L.   +6 more
core   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source