Results 111 to 120 of about 77,676 (146)

Familial defective apolipoprotein B-100: A review

Journal of Clinical Lipidology, 2016
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant genetic disorder of lipid metabolism associated with hyperlipidemia and elevated risk for atherosclerosis. FDB is caused by mutations in APOB reducing the binding affinity between apolipoprotein B-100 and the low-density lipoprotein receptor.
Lars H. Andersen, André R. Miserez, Zahid Ahmad, Rolf L. Andersen   +3 more
openaire   +2 more sources

Genetic determinants of apolipoprotein B-100 kinetics

Current Opinion in Lipidology, 2010
We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism.In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP B1B1, is independently associated with lower VLDL apoB secretion ...
Theodore W K, Ng, Esther M M, Ooi, Gerald F, Watts, Dick C, Chan, P Hugh R, Barrett   +4 more
openaire   +2 more sources

Decreased Production and Increased Catabolism of Apolipoprotein B-100 in Apolipoprotein B-67/B-100 Heterozygotes

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Abstract Apolipoprotein (apo) B-67 is a truncated form of apoB-100 due to deletion of an adenine at cDNA 9327. Heterozygotes have one allele making apoB-100; therefore, plasma apoB levels would be predicted to be at least 50% of normal. However, apoB-67 heterozygotes have total plasma apoB levels that are 24% of normal.
F K, Welty, A H, Lichtenstein, P H, Barrett, G G, Dolnikowski, J M, Ordovas, E J, Schaefer   +5 more
openaire   +2 more sources

Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
S B, Edge, J M, Hoeg, P D, Schneider, H B, Brewer   +3 more
openaire   +2 more sources

Reduction of Lipid Hydroperoxides by Apolipoprotein B-100

Biochemical and Biophysical Research Communications, 1999
We have previously isolated two proteins which can reduce phosphatidylcholine hydroperoxide (PC-OOH) from human blood plasma and identified one of the proteins as apolipoprotein A-I (Mashima, R. , et al. (1998) J. Lipid Res. 39, 1133-1140). In the present study we have identified the other protein as apolipoprotein B-100 (apo B-100) by amino acid ...
R, Mashima, S, Yoshimura, Y, Yamamoto
openaire   +2 more sources

Degradation of apolipoprotein B-100 in human chylomicrons

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
The purpose of this study was to investigate the molecular forms of apolipoprotein B (ApoB) in human chylomicrons under well-preserved conditions. To this end, plasma and serum were collected from the same normal subjects after ingestion of a fatty meal.
D M, Lee, S, Singh
openaire   +2 more sources

[Familial defective apolipoprotein B-100].

Ryoikibetsu shokogun shirizu, 1998
Abnormal interaction between low density lipoprotein receptors (LDLR) and their ligands, apolipoprotein E and B, causes decreased catabolism of lipoproteins which carry these apolipoproteins (VLDL, IDL and/or LDL) and thereby increased plasma concentrations of these. In familial hypercholesterolemia (FH), abnormal interaction is due to mutations in the
A, Nohara, H, Mabuchi
openaire   +3 more sources

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

Biological Chemistry, 2006
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsins were demonstrated to transform native LDL particles into a proatherogenic type, the following study was ...
Martin, Linke, Ronald E, Gordon, Michèle, Brillard, Fabien, Lecaille, Gilles, Lalmanach, Dieter, Brömme   +5 more
openaire   +2 more sources

Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele

Atherosclerosis, 1997
Familial defective apo B-100 (FDB) is an autosomal dominant condition resulting in hypercholesterolemia. It is generally observed in 1-6% of hypercholesterolemic subjects in Caucasian populations studied. There are, thus far, no reports characterizing the frequency and phenotype of FDB in a Chinese population. We report on the frequency of the FDB (Arg(
L O, Abdel-Wareth, S N, Pimstone, J P, Lagarde, A, Raisonnier, P, Benlian, H, Pritchard, M R, Hayden, J J, Frohlich   +7 more
openaire   +2 more sources