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Real-world experience with lecanemab therapy for Alzheimer's disease in the Intermountain West. [PDF]

open access: yesAlzheimers Dement (Amst)
Curd BC   +8 more
europepmc   +1 more source
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Familial defective apolipoprotein B-100: A review

Journal of Clinical Lipidology, 2016
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant genetic disorder of lipid metabolism associated with hyperlipidemia and elevated risk for atherosclerosis. FDB is caused by mutations in APOB reducing the binding affinity between apolipoprotein B-100 and the low-density lipoprotein receptor.
Lars H. Andersen   +3 more
openaire   +2 more sources

Genetic determinants of apolipoprotein B-100 kinetics

Current Opinion in Lipidology, 2010
We review stable isotope tracer studies of apolipoprotein B-100 (apoB) kinetics concerning genetic polymorphisms and mutations that affect human lipoprotein metabolism.In obese men, the allelic combination of the apoB signal peptide, SP24, and cholesteryl ester transfer protein, CETP B1B1, is independently associated with lower VLDL apoB secretion ...
Theodore W K, Ng   +4 more
openaire   +2 more sources

Decreased Production and Increased Catabolism of Apolipoprotein B-100 in Apolipoprotein B-67/B-100 Heterozygotes

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Abstract Apolipoprotein (apo) B-67 is a truncated form of apoB-100 due to deletion of an adenine at cDNA 9327. Heterozygotes have one allele making apoB-100; therefore, plasma apoB levels would be predicted to be at least 50% of normal. However, apoB-67 heterozygotes have total plasma apoB levels that are 24% of normal.
F K, Welty   +5 more
openaire   +2 more sources

Apolipoprotein B synthesis in humans: Liver synthesizes only apolipoprotein B-100

Metabolism, 1985
Apolipoprotein (apo) B-100 and B-48 are prominent apolipoproteins in VLDL, IDL, and chylomicrons. Organ cultures of normal adult human liver were established to ascertain the form of apo B synthesized by hepatocytes in humans. Human liver was minced and incubated in 15 mL methionine-free RPMI-1640 medium with 10% dialyzed fetal calf serum plus 250 ...
S B, Edge   +3 more
openaire   +2 more sources

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