Results 301 to 310 of about 145,356 (331)

Reduction of Lipid Hydroperoxides by Apolipoprotein B-100

Biochemical and Biophysical Research Communications, 1999
We have previously isolated two proteins which can reduce phosphatidylcholine hydroperoxide (PC-OOH) from human blood plasma and identified one of the proteins as apolipoprotein A-I (Mashima, R. , et al. (1998) J. Lipid Res. 39, 1133-1140). In the present study we have identified the other protein as apolipoprotein B-100 (apo B-100) by amino acid ...
R, Mashima, S, Yoshimura, Y, Yamamoto
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Degradation of apolipoprotein B-100 in human chylomicrons

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
The purpose of this study was to investigate the molecular forms of apolipoprotein B (ApoB) in human chylomicrons under well-preserved conditions. To this end, plasma and serum were collected from the same normal subjects after ingestion of a fatty meal.
D M, Lee, S, Singh
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[Familial defective apolipoprotein B-100].

Ryoikibetsu shokogun shirizu, 1998
Abnormal interaction between low density lipoprotein receptors (LDLR) and their ligands, apolipoprotein E and B, causes decreased catabolism of lipoproteins which carry these apolipoproteins (VLDL, IDL and/or LDL) and thereby increased plasma concentrations of these. In familial hypercholesterolemia (FH), abnormal interaction is due to mutations in the
A, Nohara, H, Mabuchi
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Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

Biological Chemistry, 2006
Although the degradation of cellular or endocytosed proteins comprises the normal function of lysosomal proteinases, these enzymes were also detected extracellularly during diseases such as atherosclerosis. Since lysosomal cysteine cathepsins were demonstrated to transform native LDL particles into a proatherogenic type, the following study was ...
Martin, Linke, Ronald E, Gordon, Michèle, Brillard, Fabien, Lecaille, Gilles, Lalmanach, Dieter, Brömme   +5 more
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Familial defective apolipoprotein B-100 in hypercholesterolemic Chinese Canadians: identification of a unique haplotype of the apolipoprotein B-100 allele

Atherosclerosis, 1997
Familial defective apo B-100 (FDB) is an autosomal dominant condition resulting in hypercholesterolemia. It is generally observed in 1-6% of hypercholesterolemic subjects in Caucasian populations studied. There are, thus far, no reports characterizing the frequency and phenotype of FDB in a Chinese population. We report on the frequency of the FDB (Arg(
L O, Abdel-Wareth, S N, Pimstone, J P, Lagarde, A, Raisonnier, P, Benlian, H, Pritchard, M R, Hayden, J J, Frohlich   +7 more
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Apolipoprotein B-100 Xba I gene polymorphism in gallbladder cancer

Human Genetics, 2004
Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBC).
Mahendra Kumar, Singh, Udai Bhan, Pandey, Uday Chand, Ghoshal, Itha, Srivenu, Vinay Kumar, Kapoor, Gourdas, Choudhuri, Balraj, Mittal   +6 more
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Homozygous Familial Defective Apolipoprotein B-100

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Familial defective apolipoprotein B-100 (FDB) is a frequently inherited disorder of lipoprotein metabolism. The glutamine-for-arginine substitution at position 3500 of apolipoprotein (apo) B-100 leads to defective binding of apo B-100 to the low density lipoprotein (LDL) receptor and accumulation of LDL in the plasma.
Schaefer, Juergen R., Scharnagl, Hubert, Baumstark, Manfred, Schweer, Horst, Zech, Loren A., Seyberth, Hansjörg W., Winkler, Karl, Steinmetz, Armin C., März, Winfried   +8 more
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Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100

The Lancet, 1992
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant disorder associated with hypercholesterolaemia in which an aminoacid substitution in apoprotein B-100 leads to low-density lipoprotein (LDL) particles which have defective binding to the LDL receptor.
D R, Illingworth, F, Vakar, R W, Mahley, K H, Weisgraber   +3 more
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Apolipoprotein B-100 Hopkins (Arginine4019 [unk] Tryptophan)

JAMA, 1989
A 43-year-old woman with severe coronary artery disease and hyperapobetalipoproteinemia was heterozygous for an abnormal Msp I apolipoprotein B (APOB) gene fragment because of the absence of the MspI site around codon 4046 in exon 29 of the APOB gene.
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Lipoproteins Containing Apolipoprotein B-100 Are Secreted by the Heart

Trends in Cardiovascular Medicine, 1999
It generally is assumed that lipoproteins containing apolipoprotein B (apo B) are secreted only by the intestine and the liver. However, we recently demonstrated that the human apo-B gene also is expressed in the hearts of human apo-B transgenic mice and in human heart tissue.
M M, Véniant, L B, Nielsen, J, Borén, S G, Young   +3 more
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